OTUD3 and BGLT3

Number of citations of the paper that reports this interaction (PubMedID 33543443)
0

Data Source:
BioGRID (unspecified method)

		OTUD3	BGLT3
Description		OTU deubiquitinase 3	beta globin locus transcript 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Proteolysis Protein Deubiquitination Cellular Response To Nutrient Levels Ribosome Disassembly Protein K11-linked Deubiquitination Protein K6-linked Deubiquitination Protein Stabilization Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein K48-linked Deubiquitination Rescue Of Stalled Ribosome Energy Homeostasis Protein K27-linked Deubiquitination
Pathways		Ovarian tumor domain proteases Regulation of PTEN stability and activity
Drugs
Diseases
GWAS		Group IIA secretory phospholipase A2 levels in individuals with elevated hsCRP ( 31070471) Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 19122664 19915572 20228798 20228799 23511034 28067908)	Malaria ( 31844061)
Interacting Genes		17 interacting genes: ATG14 BGLT3 BHLHE22 CGAS FOXA2 FOXN1 HNF1B HOXB8 HSD17B14 HSPA5 IREB2 PPARD SIX3 STUB1 TP53 UBC UBE2L3	7 interacting genes: BARD1 FARP2 KAT7 OTUD3 PARP1 PTEN TBL2
Entrez ID		23252	103344929
HPRD ID		19417
Ensembl ID		ENSG00000169914	ENSG00000260629
Uniprot IDs		Q5T2D3
PDB IDs		4BOU
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Chromatin Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Anterior/posterior Pattern Specification Cellular Response To Glucose Starvation Ubiquitin Protein Ligase Binding Regulation Of Primary Metabolic Process DNA-binding Transcription Factor Activity Positive Regulation Of RNA Metabolic Process ER Overload Response Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Senescence Endocrine Pancreas Development Cellular Response To Nutrient Levels Misfolded Protein Binding Transcription Cis-regulatory Region Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Regionalization Protein-folding Chaperone Binding Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Protein Ubiquitination Regulation Of Gene Expression Intracellular Signaling Cassette Circadian Behavior Regulation Of Macromolecule Biosynthetic Process Rhythmic Behavior Regulation Of RNA Metabolic Process Sequence-specific Double-stranded DNA Binding Negative Regulation Of Developmental Process Positive Regulation Of Post-translational Protein Modification Cellular Response To Hypoxia Negative Regulation Of RNA Metabolic Process Cellular Response To Decreased Oxygen Levels T Cell Lineage Commitment Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Catabolic Process Apoptotic Process Involved In Development Determination Of Adult Lifespan	Protein Modification Process NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity Site Of DNA Damage NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity Regulation Of DNA Repair Positive Regulation Of DNA-templated Transcription, Elongation Leukocyte Differentiation NAD+-protein-histidine ADP-ribosyltransferase Activity NAD+-protein-tyrosine ADP-ribosyltransferase Activity Intracellular Signal Transduction Negative Regulation Of MRNA 3'-end Processing Negative Regulation Of Synaptic Vesicle Clustering Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Histone H3K23 Acetyltransferase Activity Histone H3K4 Acetyltransferase Activity Regulation Of DNA Metabolic Process Positive Regulation Of Myofibroblast Differentiation NAD+-protein-serine ADP-ribosyltransferase Activity Regulation Of DNA-templated Transcription Elongation Positive Regulation Of Protein Localization To Nucleus Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Histone H3-K14 Acetyltransferase Complex Response To Dithiothreitol DNA Repair Regulation Of Phosphorus Metabolic Process DNA ADP-ribosylation Negative Regulation Of ATP Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Cellular Response To Stress NAD DNA ADP-ribosyltransferase Activity Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission DNA Replication-dependent Chromatin Disassembly Protein K6-linked Deubiquitination Regulation Of Base-excision Repair Myeloid Leukocyte Differentiation ATP Generation From Poly-ADP-D-ribose Response To Ionizing Radiation Signal Transduction BRCA1-B Complex Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Response To Anisomycin Response To Sorbitol
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