OTUD3 and BHLHE22

Number of citations of the paper that reports this interaction (PubMedID 35675826)
0

Data Source:
BioGRID (enzymatic study)

		OTUD3	BHLHE22
Description		OTU deubiquitinase 3	basic helix-loop-helix family member e22
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Chromatin Nucleus
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Dimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Proteolysis Protein Deubiquitination Cellular Response To Nutrient Levels Ribosome Disassembly Protein K11-linked Deubiquitination Protein K6-linked Deubiquitination Protein Stabilization Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein K48-linked Deubiquitination Rescue Of Stalled Ribosome Energy Homeostasis Protein K27-linked Deubiquitination	Nervous System Development Sensory Organ Development Positive Regulation Of Transcription By RNA Polymerase II Axon Development
Pathways		Ovarian tumor domain proteases Regulation of PTEN stability and activity	Regulation of CDH11 gene transcription
Drugs
Diseases
GWAS		Group IIA secretory phospholipase A2 levels in individuals with elevated hsCRP ( 31070471) Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 19122664 19915572 20228798 20228799 23511034 28067908)	Adventurousness ( 30643258) Alcohol consumption ( 31358974) Automobile speeding propensity ( 30643258) Body mass index ( 26426971) Chronotype ( 30696823) General risk tolerance (MTAG) ( 30643258) Neurociticism ( 29500382)
Interacting Genes		17 interacting genes: ATG14 BGLT3 BHLHE22 CGAS FOXA2 FOXN1 HNF1B HOXB8 HSD17B14 HSPA5 IREB2 PPARD SIX3 STUB1 TP53 UBC UBE2L3	1 interacting genes: OTUD3
Entrez ID		23252	27319
HPRD ID		19417	16551
Ensembl ID		ENSG00000169914	ENSG00000180828
Uniprot IDs		Q5T2D3	B4DF88 Q8NFJ8
PDB IDs		4BOU
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Chromatin Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Anterior/posterior Pattern Specification Cellular Response To Glucose Starvation Ubiquitin Protein Ligase Binding Regulation Of Primary Metabolic Process DNA-binding Transcription Factor Activity Positive Regulation Of RNA Metabolic Process ER Overload Response Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Senescence Endocrine Pancreas Development Cellular Response To Nutrient Levels Misfolded Protein Binding Transcription Cis-regulatory Region Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Regionalization Protein-folding Chaperone Binding Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Protein Ubiquitination Regulation Of Gene Expression Intracellular Signaling Cassette Circadian Behavior Regulation Of Macromolecule Biosynthetic Process Rhythmic Behavior Regulation Of RNA Metabolic Process Sequence-specific Double-stranded DNA Binding Negative Regulation Of Developmental Process Positive Regulation Of Post-translational Protein Modification Cellular Response To Hypoxia Negative Regulation Of RNA Metabolic Process Cellular Response To Decreased Oxygen Levels T Cell Lineage Commitment Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Catabolic Process Apoptotic Process Involved In Development Determination Of Adult Lifespan	Protein K6-linked Deubiquitination Protein K27-linked Deubiquitination Protein K11-linked Deubiquitination Protein K48-linked Deubiquitination Rescue Of Stalled Ribosome Ribosome Disassembly Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Translational Elongation Organelle Disassembly Energy Homeostasis Cysteine-type Deubiquitinase Activity Protein Deubiquitination Protein Modification By Small Protein Removal Cysteine-type Peptidase Activity
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