OTUD3 and CGAS

Number of citations of the paper that reports this interaction (PubMedID 36966392)
0

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study)

		OTUD3	CGAS
Description		OTU deubiquitinase 3	cyclic GMP-AMP synthase
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Plasma Membrane Membrane Nuclear Body Site Of Double-strand Break
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity	Nucleotide Binding DNA Binding Chromatin Binding Double-stranded DNA Binding Protein Binding ATP Binding GTP Binding Phosphatidylinositol-4,5-bisphosphate Binding Lipid Binding Transferase Activity Nucleotidyltransferase Activity Nucleosome Binding Protein Homodimerization Activity Metal Ion Binding 2',3'-cyclic GMP-AMP Synthase Activity Molecular Condensate Scaffold Activity Poly-ADP-D-ribose Modification-dependent Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Proteolysis Protein Deubiquitination Cellular Response To Nutrient Levels Ribosome Disassembly Protein K11-linked Deubiquitination Protein K6-linked Deubiquitination Protein Stabilization Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein K48-linked Deubiquitination Rescue Of Stalled Ribosome Energy Homeostasis Protein K27-linked Deubiquitination	Activation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Defense Response To Virus By Host Immune System Process Regulation Of Immunoglobulin Production Cytoplasmic Pattern Recognition Receptor Signaling Pathway DNA Repair DNA Damage Response Determination Of Adult Lifespan CAMP-mediated Signaling CGMP-mediated Signaling Signal Transduction Involved In Regulation Of Gene Expression Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Paracrine Signaling Innate Immune Response Negative Regulation Of DNA Repair Regulation Of Immune Response Regulation Of T Cell Activation Defense Response To Virus Cellular Response To Exogenous DsRNA CGAS/STING Signaling Pathway Negative Regulation Of CGAS/STING Signaling Pathway Positive Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Cellular Senescence
Pathways		Ovarian tumor domain proteases Regulation of PTEN stability and activity	STING mediated induction of host immune responses
Drugs
Diseases
GWAS		Group IIA secretory phospholipase A2 levels in individuals with elevated hsCRP ( 31070471) Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 19122664 19915572 20228798 20228799 23511034 28067908)
Interacting Genes		17 interacting genes: ATG14 BGLT3 BHLHE22 CGAS FOXA2 FOXN1 HNF1B HOXB8 HSD17B14 HSPA5 IREB2 PPARD SIX3 STUB1 TP53 UBC UBE2L3	4 interacting genes: IRGM MARCHF8 OTUD3 RNF185
Entrez ID		23252	115004
HPRD ID		19417	12857
Ensembl ID		ENSG00000169914	ENSG00000164430
Uniprot IDs		Q5T2D3	A0A7P0TBQ3 Q8N884
PDB IDs		4BOU	4KM5 4LEV 4LEW 4MKP 4O67 4O68 4O69 5V8O 5VDO 5VDP 5VDQ 5VDR 5VDS 5VDT 5VDU 5VDV 5VDW 6CT9 6CTA 6EDB 6EDC 6LRC 6LRE 6LRI 6LRJ 6LRK 6LRL 6MJU 6MJW 6MJX 6NAO 6NFG 6NFO 6O47 6Y5D 6Y5E 7C0M 7CCQ 7CCR 7FTF 7FTG 7FTH 7FTI 7FTJ 7FTK 7FTL 7FTM 7FTN 7FTO 7FTP 7FTQ 7FTR 7FTS 7FTT 7FTU 7FTV 7FTW 7FTX 7FTY 7FTZ 7FU0 7FU1 7FU2 7FU3 7FU4 7FU5 7FU6 7FU7 7FU8 7FU9 7FUA 7FUB 7FUC 7FUD 7FUE 7FUF 7FUG 7FUH 7FUI 7FUJ 7FUK 7FUL 7FUM 7FUN 7FUO 7FUP 7FUQ 7FUR 8IME 8IMF 8IMG 8OKX 8OL1 8SHZ 8SI0 8SJ8 8WR8 9C3G 9ELX 9MDC 9MDD
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Chromatin Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Anterior/posterior Pattern Specification Cellular Response To Glucose Starvation Ubiquitin Protein Ligase Binding Regulation Of Primary Metabolic Process DNA-binding Transcription Factor Activity Positive Regulation Of RNA Metabolic Process ER Overload Response Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Senescence Endocrine Pancreas Development Cellular Response To Nutrient Levels Misfolded Protein Binding Transcription Cis-regulatory Region Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Regionalization Protein-folding Chaperone Binding Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Protein Ubiquitination Regulation Of Gene Expression Intracellular Signaling Cassette Circadian Behavior Regulation Of Macromolecule Biosynthetic Process Rhythmic Behavior Regulation Of RNA Metabolic Process Sequence-specific Double-stranded DNA Binding Negative Regulation Of Developmental Process Positive Regulation Of Post-translational Protein Modification Cellular Response To Hypoxia Negative Regulation Of RNA Metabolic Process Cellular Response To Decreased Oxygen Levels T Cell Lineage Commitment Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Catabolic Process Apoptotic Process Involved In Development Determination Of Adult Lifespan	Post-translational Protein Modification Protein Modification Process Positive Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein Lipidation Involved In Autophagosome Assembly Protein K6-linked Deubiquitination Protein K27-linked Deubiquitination Protein Metabolic Process Innate Immune Response-activating Signaling Pathway Endoplasmic Reticulum Membrane Pattern Recognition Receptor Signaling Pathway Activation Of Innate Immune Response Regulation Of Cytokine-mediated Signaling Pathway Late Endosome Membrane Positive Regulation Of Lysosome Organization C-terminal Protein Lipidation Protein Stabilization Protein Polyubiquitination Immune Response Autophagy Ubiquitin-like Protein Conjugating Enzyme Binding Positive Regulation Of Innate Immune Response Intracellular Receptor Signaling Pathway Ubiquitin-protein Transferase Activity MHC Protein Binding Positive Regulation Of Xenophagy Positive Regulation Of Response To Type II Interferon Positive Regulation Of Type II Interferon-mediated Signaling Pathway Positive Regulation Of Autophagosome Maturation BH3 Domain Binding CAMKK-AMPK Signaling Cascade Positive Regulation Of Peptidyl-threonine Phosphorylation Ubiquitin Protein Ligase Activity Immune Response-activating Signaling Pathway Protein K11-linked Deubiquitination Regulation Of Protein Stability Protein Alpha-1,2-demannosylation Regulation Of Innate Immune Response Response To Virus Immune Response-regulating Signaling Pathway Endoplasmic Reticulum Mannose Trimming Protein K27-linked Ubiquitination Activation Of Immune Response Lysosomal Membrane Regulation Of Protein Complex Stability Negative Regulation Of NLRP3 Inflammasome Complex Assembly Regulation Of Lysosome Organization Protein Targeting To Vacuole Involved In Autophagy Regulation Of Type II Interferon-mediated Signaling Pathway
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