PMPCA and ASS1

Data Source: HiPPIP (Novel)

		PMPCA	ASS1
Name		peptidase, mitochondrial processing subunit alpha	argininosuccinate synthase 1
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Membrane Mitochondrial Processing Peptidase Complex	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Neuronal Cell Body Perikaryon Extracellular Exosome Cell Body Fiber
	Molecular Function	Metalloendopeptidase Activity Protein Binding Metal Ion Binding	Nucleotide Binding RNA Binding Argininosuccinate Synthase Activity Protein Binding ATP Binding Toxic Substance Binding Amino Acid Binding Ligase Activity Identical Protein Binding
	Biological Process	Proteolysis Protein Processing Involved In Protein Targeting To Mitochondrion Protein Processing	Urea Cycle Citrulline Metabolic Process Argininosuccinate Metabolic Process Kidney Development Liver Development L-arginine Biosynthetic Process Aspartate Metabolic Process Acute-phase Response Midgut Development Response To Nutrient Circadian Rhythm Amino Acid Biosynthetic Process Response To Xenobiotic Stimulus Response To Toxic Substance Response To Zinc Ion Response To Mycotoxin Response To Amine Response To Estradiol Response To Lipopolysaccharide Response To Amino Acid Response To Peptide Hormone Positive Regulation Of Nitric Oxide Biosynthetic Process Response To Steroid Hormone Response To Glucocorticoid Response To Growth Hormone Diaphragm Development Response To Fatty Acid Cellular Response To Lipopolysaccharide Cellular Response To Amino Acid Stimulus Cellular Response To Ammonium Ion Cellular Response To CAMP Cellular Response To Type II Interferon Cellular Response To Tumor Necrosis Factor Cellular Response To Glucagon Stimulus Cellular Response To Oleic Acid Cellular Response To Amine Stimulus Cellular Response To Laminar Fluid Shear Stress Cellular Response To Dexamethasone Stimulus Negative Regulation Of Leukocyte Cell-cell Adhesion
Pathways		Mitochondrial protein import Processing of SMDT1 Mitochondrial protein degradation	Urea cycle
Drugs		None	Arginine Aspartic acid Aspartic acid Citrulline Citrulline ATP
Diseases		None	Citrullinemia (CTLN)
GWAS		Apolipoprotein B levels ( 32203549 ) Chronotype ( 30696823 ) Crohn's disease ( 28067908 ) Granulocyte count ( 27863252 ) Inflammatory bowel disease ( 23128233 28067908 ) Joint damage in rheumatoid arthritis ( 26498133 ) LDL cholesterol levels ( 32203549 ) Myeloid white cell count ( 27863252 ) Neutrophil count ( 27863252 ) Serum total protein levels ( 29403010 ) Sum basophil neutrophil counts ( 27863252 ) Sum neutrophil eosinophil counts ( 27863252 ) Ulcerative colitis ( 28067908 ) White blood cell count ( 27863252 )	Femur bone mineral density x serum urate levels interaction ( 34046847 )
Novel Interactors		10 novel interactors: ASS1 AVEN KIF2C NDOR1 NPSR1 NSMF OLFM1 PCDHB4 SCUBE1 UBAC1	3 novel interactors: NUP214 PMPCA STOM
Interacting Genes		6 interacting genes: BMPR2 LINC01554 OGT PMPCB SKIC2 ZNF76	15 interacting genes: AKTIP APP ARAF ASCC2 ELN JAK2 LINC01554 MLH1 MT2A PTPN1 SLC13A1 SUMO2 TERF1 TERF2 USP4
Entrez ID		23203	445
HPRD ID		07500	04590
Ensembl ID		ENSG00000165688	ENSG00000130707
Uniprot IDs		Q10713 Q5SXN9	P00966 Q5T6L4
PDB IDs		Not available	2NZ2
GO Terms Enriched among Interactors		Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Receptor Localization To Synapse Regulation Of Protein Localization To Synapse	Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Endosome Lumen Negative Regulation Of Mitotic Recombination Cellular Response To Interleukin-3 Regulation Of Mitotic Recombination Telomerase Activity Shelterin Complex Signaling Receptor Activator Activity Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Telomere Localization Nuclear Telomere Cap Complex Telomeric D-loop Disassembly Double-stranded Telomeric DNA Binding G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Telomere Capping Acetylcholine Receptor Binding Postsynapse Growth Hormone Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Protein Metabolic Process Intracellular Copper Ion Homeostasis Regulation Of Establishment Of Protein Localization Copper Ion Homeostasis Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of Phosphorus Metabolic Process Insulin Receptor Binding Cellular Response To Copper Ion Positive Regulation Of Phosphate Metabolic Process Growth Hormone Receptor Signaling Pathway RNA-templated DNA Biosynthetic Process Negative Regulation Of DNA Metabolic Process Ephrin Receptor Binding Telomeric DNA Binding Positive Regulation Of Macromolecule Metabolic Process Microglial Cell Activation Regulation Of Protein Modification Process Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Amyloid-beta Complex Positive Regulation Of Metabolic Process Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Positive Regulation Of Nitric Oxide Biosynthetic Process Response To Copper Ion Enzyme Binding Regulation Of Response To Calcium Ion Response To Nerve Growth Factor Cell Activation Involved In Immune Response