PMPCA and PMPCB

Number of citations of the paper that reports this interaction (PMID 10942759)
9

Data Source:
HPRD (in vitro)

		PMPCA	PMPCB
Gene Name		peptidase (mitochondrial processing) alpha	peptidase (mitochondrial processing) beta
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix	Mitochondrial Inner Membrane Mitochondrial Matrix
	Molecular Function	Metalloendopeptidase Activity Metal Ion Binding	Metalloendopeptidase Activity Metal Ion Binding
	Biological Process	Proteolysis Protein Targeting To Mitochondrion Cellular Protein Metabolic Process	Proteolysis Protein Targeting To Mitochondrion Cellular Protein Metabolic Process
Pathways		Mitochondrial protein import	Mitochondrial protein import
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		3 interactors: BMPR2 PMPCB SKIV2L	3 interactors: FXN MARK3 PMPCA
Entrez ID		23203	9512
HPRD ID		07500	07539
Ensembl ID		ENSG00000165688	ENSG00000105819
Uniprot IDs		Q10713	B3KM34 E7ERZ4 O75439 Q96CP5
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Lung Blood Pressure Negative Regulation Of Chondrocyte Proliferation Negative Regulation Of Vasoconstriction Positive Regulation Of Axon Extension Involved In Axon Guidance Lymphatic Endothelial Cell Differentiation Lymphangiogenesis Lymph Vessel Morphogenesis Regulation Of Axon Extension Involved In Axon Guidance Venous Blood Vessel Development Retina Vasculature Development In Camera-type Eye Lymph Vessel Development Negative Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of DNA Biosynthetic Process	Regulation Of Ferrochelatase Activity Iron Incorporation Into Metallo-sulfur Cluster Proprioception Mitochondrion Organization Positive Regulation Of Metalloenzyme Activity Protein Autoprocessing Neuromuscular Process Controlling Posture Negative Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Multicellular Organism Growth Iron-sulfur Cluster Assembly Heme Biosynthetic Process Negative Regulation Of Mitochondrion Organization Response To Iron Ion Porphyrin-containing Compound Biosynthetic Process Negative Regulation Of Organ Growth Positive Regulation Of Oxidoreductase Activity Heme Metabolic Process Positive Regulation Of Lyase Activity Adult Walking Behavior Cellular Protein Metabolic Process Porphyrin-containing Compound Metabolic Process Pigment Biosynthetic Process Cellular Response To Hydrogen Peroxide Aerobic Respiration Protein Targeting To Mitochondrion Oxidative Phosphorylation Protein Localization To Mitochondrion Regulation Of Oxidoreductase Activity
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