ASS1 and USP4

Number of citations of the paper that reports this interaction (PubMedID 23022198)
0

Data Source:
BioGRID (two hybrid)

		ASS1	USP4
Description		argininosuccinate synthase 1	ubiquitin specific peptidase 4
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Neuronal Cell Body Perikaryon Extracellular Exosome Cell Body Fiber	Nucleus Cytoplasm Lysosome Cytosol
	Molecular Function	Nucleotide Binding RNA Binding Argininosuccinate Synthase Activity Protein Binding ATP Binding Toxic Substance Binding Amino Acid Binding Ligase Activity Identical Protein Binding	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Adenosine Receptor Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Urea Cycle Citrulline Metabolic Process Argininosuccinate Metabolic Process Kidney Development Liver Development L-arginine Biosynthetic Process Aspartate Metabolic Process Acute-phase Response Midgut Development Response To Nutrient Circadian Rhythm Amino Acid Biosynthetic Process Response To Xenobiotic Stimulus Response To Toxic Substance Response To Zinc Ion Response To Mycotoxin Response To Amine Response To Estradiol Response To Lipopolysaccharide Response To Amino Acid Response To Peptide Hormone Positive Regulation Of Nitric Oxide Biosynthetic Process Response To Steroid Hormone Response To Glucocorticoid Response To Growth Hormone Diaphragm Development Response To Fatty Acid Cellular Response To Lipopolysaccharide Cellular Response To Amino Acid Stimulus Cellular Response To Ammonium Ion Cellular Response To CAMP Cellular Response To Type II Interferon Cellular Response To Tumor Necrosis Factor Cellular Response To Glucagon Stimulus Cellular Response To Oleic Acid Cellular Response To Amine Stimulus Cellular Response To Laminar Fluid Shear Stress Cellular Response To Dexamethasone Stimulus Negative Regulation Of Leukocyte Cell-cell Adhesion	Spliceosomal Tri-snRNP Complex Assembly Cytoplasmic Translation Proteolysis Cellular Response To Starvation Protein Deubiquitination Negative Regulation Of Protein Ubiquitination Regulation Of Protein Stability Cellular Response To Nutrient Levels Protein Localization To Cell Surface TORC1 Signaling Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling
Pathways		Urea cycle	TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Ub-specific processing proteases
Drugs		Arginine Aspartic acid Aspartic acid Citrulline Citrulline ATP
Diseases		Citrullinemia (CTLN)
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Glycated hemoglobin levels ( 34059833 28898252) High light scatter reticulocyte percentage of red cells ( 27863252) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908 23128233) Intelligence (MTAG) ( 29326435) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Red cell distribution width ( 32888494) Refractive error ( 32231278) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252 32888494) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908 25082827)
Interacting Genes		15 interacting genes: AKTIP APP ARAF ASCC2 ELN JAK2 LINC01554 MLH1 MT2A PTPN1 SLC13A1 SUMO2 TERF1 TERF2 USP4	49 interacting genes: AKT1 ANXA7 ASS1 ATP1B1 ATP1B3 BDKRB2 BRAP CDKN1A CIAO2B DLC1 HDAC2 IGKV2D-29 IRF4 LAMA5 LGALS1 MAP3K7 NLK NOLC1 NPC2 PCNA PDK1 PGM1 PLA2G2A PLOD1 PPIA PRPF3 PSAP PSMA6 PSMC5 PSMD11 RB1 RBBP8 RBL1 RBL2 RCC1 RHEB RNPS1 SMAD4 SMN1 TK1 TP53BP2 TRAF2 TRIM21 TRIM54 TRIM55 TRIM63 UBC USP21 USP28
Entrez ID		445	7375
HPRD ID		04590	04598
Ensembl ID		ENSG00000130707	ENSG00000114316
Uniprot IDs		P00966 Q5T6L4	Q08AK7 Q13107
PDB IDs		2NZ2	2Y6E 5CTR
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Endosome Lumen Negative Regulation Of Mitotic Recombination Cellular Response To Interleukin-3 Regulation Of Mitotic Recombination Telomerase Activity Shelterin Complex Signaling Receptor Activator Activity Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Telomere Localization Nuclear Telomere Cap Complex Telomeric D-loop Disassembly Double-stranded Telomeric DNA Binding G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Telomere Capping Acetylcholine Receptor Binding Postsynapse Growth Hormone Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Protein Metabolic Process Intracellular Copper Ion Homeostasis Regulation Of Establishment Of Protein Localization Copper Ion Homeostasis Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of Phosphorus Metabolic Process Insulin Receptor Binding Cellular Response To Copper Ion Positive Regulation Of Phosphate Metabolic Process Growth Hormone Receptor Signaling Pathway RNA-templated DNA Biosynthetic Process Negative Regulation Of DNA Metabolic Process Ephrin Receptor Binding Telomeric DNA Binding Positive Regulation Of Macromolecule Metabolic Process Microglial Cell Activation Regulation Of Protein Modification Process Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Amyloid-beta Complex Positive Regulation Of Metabolic Process Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Positive Regulation Of Nitric Oxide Biosynthetic Process Response To Copper Ion Enzyme Binding Regulation Of Response To Calcium Ion Response To Nerve Growth Factor Cell Activation Involved In Immune Response	Regulation Of Lipid Kinase Activity Intracellular Signal Transduction Nucleoplasm Regulation Of Phosphorus Metabolic Process Regulation Of Catalytic Activity Intracellular Signaling Cassette Macromolecule Metabolic Process Extracellular Exosome PCNA-p21 Complex Regulation Of Kinase Activity Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Response To Stress Nucleus Identical Protein Binding Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Phosphorylation Positive Regulation Of Catalytic Activity TORC1 Signaling Regulation Of Cell Cycle Apoptotic Signaling Pathway Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Deoxyribonuclease Activity Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Cell Cycle Phase Transition Protein-containing Complex Cytoplasm Cytosol Response To External Biotic Stimulus Negative Regulation Of Cell Cycle Signal Transduction Positive Regulation Of Potassium Ion Import Across Plasma Membrane Sulfate Binding Cellular Response To Stress G1/S Transition Of Mitotic Cell Cycle Regulation Of G1/S Transition Of Mitotic Cell Cycle TOR Signaling Cell Cycle G1/S Phase Transition Positive Regulation Of Sodium Ion Transport NF-kappaB Binding Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Potassium Ion Import Cellular Response To Chemical Stress Protein Modification Process Negative Regulation Of Cell Cycle Process Epithelial Cell Differentiation DNA-binding Transcription Factor Binding Positive Regulation Of Interleukin-2 Production Cell Differentiation Regulation Of Cell Cycle G1/S Phase Transition
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