ASS1 and SLC13A1

Number of citations: 55 (PubMedID 18407958)
Data Source: BioGRID (protein complementation assay)

		ASS1	SLC13A1
Name		argininosuccinate synthase 1	solute carrier family 13 member 1
Structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Neuronal Cell Body Perikaryon Extracellular Exosome Cell Body Fiber	Plasma Membrane Membrane Apical Plasma Membrane
	Molecular Function	Nucleotide Binding RNA Binding Argininosuccinate Synthase Activity Protein Binding ATP Binding Toxic Substance Binding Amino Acid Binding Ligase Activity Identical Protein Binding	Secondary Active Sulfate Transmembrane Transporter Activity Symporter Activity Solute:sodium Symporter Activity Monoatomic Anion:sodium Symporter Activity Sodium:sulfate Symporter Activity Transmembrane Transporter Activity
	Biological Process	Urea Cycle Citrulline Metabolic Process Argininosuccinate Metabolic Process Kidney Development Liver Development L-arginine Biosynthetic Process Aspartate Metabolic Process Acute-phase Response Midgut Development Response To Nutrient Circadian Rhythm Amino Acid Biosynthetic Process Response To Xenobiotic Stimulus Response To Toxic Substance Response To Zinc Ion Response To Mycotoxin Response To Amine Response To Estradiol Response To Lipopolysaccharide Response To Amino Acid Response To Peptide Hormone Positive Regulation Of Nitric Oxide Biosynthetic Process Response To Steroid Hormone Response To Glucocorticoid Response To Growth Hormone Diaphragm Development Response To Fatty Acid Cellular Response To Lipopolysaccharide Cellular Response To Amino Acid Stimulus Cellular Response To Ammonium Ion Cellular Response To CAMP Cellular Response To Type II Interferon Cellular Response To Tumor Necrosis Factor Cellular Response To Glucagon Stimulus Cellular Response To Oleic Acid Cellular Response To Amine Stimulus Cellular Response To Laminar Fluid Shear Stress Cellular Response To Dexamethasone Stimulus Negative Regulation Of Leukocyte Cell-cell Adhesion	Monoatomic Ion Transport Sodium Ion Transport Sodium Ion Transmembrane Transport Transmembrane Transport Monoatomic Anion Transmembrane Transport Sulfate Transmembrane Transport
Pathways		Urea cycle	Sodium-coupled sulphate, di- and tri-carboxylate transporters
Drugs		Arginine Aspartic acid Aspartic acid Citrulline Citrulline ATP	None
Diseases		Citrullinemia (CTLN)	None
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847 )	Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) ( 23648065 ) High density lipoprotein cholesterol levels ( 30498476 ) Systolic blood pressure ( 30578418 )
Interacting Genes		15 interacting genes: AKTIP APP ARAF ASCC2 ELN JAK2 LINC01554 MLH1 MT2A PTPN1 SLC13A1 SUMO2 TERF1 TERF2 USP4	31 interacting genes: ACOT2 ACTR10 APLP2 ARL6IP1 ASS1 CD59 COQ5 COQ9 CRYAB DYNLL1 FTL GRN HSPA1A MKRN1 NDUFS5 NHERF1 NHERF2 OGDHL PDZK1 PNPLA6 PRSS8 RHOA SDHD SEC61A1 SELPLG SERPINA1 TBRG1 TM4SF1 TMED10 TP53I11 TSPAN3
Entrez ID		445	6561
HPRD ID		04590	08394
Ensembl ID		ENSG00000130707	ENSG00000081800
Uniprot IDs		P00966 Q5T6L4	A4D0X1 Q2NKK0 Q9BZW2
PDB IDs		2NZ2	8W6H 8W6N 8W6O 8W6T 8Y5U 8Y5W 8Y5X 8Y5Y 8Y5Z
GO Terms Enriched among Interactors		Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Endosome Lumen Negative Regulation Of Mitotic Recombination Cellular Response To Interleukin-3 Regulation Of Mitotic Recombination Telomerase Activity Shelterin Complex Signaling Receptor Activator Activity Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Telomere Localization Nuclear Telomere Cap Complex Telomeric D-loop Disassembly Double-stranded Telomeric DNA Binding G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Telomere Capping Acetylcholine Receptor Binding Postsynapse Growth Hormone Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Protein Metabolic Process Intracellular Copper Ion Homeostasis Regulation Of Establishment Of Protein Localization Copper Ion Homeostasis Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of Phosphorus Metabolic Process Insulin Receptor Binding Cellular Response To Copper Ion Positive Regulation Of Phosphate Metabolic Process Growth Hormone Receptor Signaling Pathway RNA-templated DNA Biosynthetic Process Negative Regulation Of DNA Metabolic Process Ephrin Receptor Binding Telomeric DNA Binding Positive Regulation Of Macromolecule Metabolic Process Microglial Cell Activation Regulation Of Protein Modification Process Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Amyloid-beta Complex Positive Regulation Of Metabolic Process Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Positive Regulation Of Nitric Oxide Biosynthetic Process Response To Copper Ion Enzyme Binding Regulation Of Response To Calcium Ion Response To Nerve Growth Factor Cell Activation Involved In Immune Response	Extracellular Exosome Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Vesicle Protein-membrane Adaptor Activity Sec61 Translocon Complex Ubiquinone Biosynthesis Complex Establishment Of Epithelial Cell Apical/basal Polarity Mitochondrion Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Cellular Localization ATP Metabolic Process Aerobic Electron Transport Chain Cotranslational Protein Targeting To Membrane Ubiquinone Metabolic Process Ubiquinone Biosynthetic Process Azurophil Granule Lumen Quinone Metabolic Process Establishment Of Apical/basal Cell Polarity Signaling Receptor Binding Aerobic Respiration Respiratory Electron Transport Chain Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Polarized Epithelial Cell Differentiation Protein Stabilization Electron Transport Chain Cellular Respiration Membrane Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Establishment Of Epithelial Cell Polarity Mitotic Cleavage Furrow Formation Argininosuccinate Synthase Activity Argininosuccinate Metabolic Process Regulation Of Transport Protein Refolding Positive Regulation Of Aspartic-type Peptidase Activity Purine Ribonucleotide Metabolic Process Purine-containing Compound Metabolic Process Ficolin-1-rich Granule Lumen COP9 Signalosome Microvillus Membrane Tricarboxylic Acid Cycle Renal Phosphate Ion Absorption Protein Transmembrane Transporter Activity Cytosol To ERGIC Protein Transport Protein Localization To ERGIC COPI-coated Vesicle Budding Pronephric Nephron Development Isoprenoid Binding