PMPCA and AVEN

		PMPCA	AVEN
Description		peptidase, mitochondrial processing subunit alpha	apoptosis and caspase activation inhibitor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Membrane Mitochondrial Processing Peptidase Complex	Cytosol Endomembrane System Membrane
	Molecular Function	Metalloendopeptidase Activity Protein Binding Metal Ion Binding	Protein Binding
	Biological Process	Proteolysis Protein Processing Involved In Protein Targeting To Mitochondrion Protein Processing	Apoptotic Process Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Apoptotic Process
Pathways		Mitochondrial protein import Processing of SMDT1 Mitochondrial protein degradation	Formation of apoptosome Regulation of the apoptosome activity
Drugs
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Chronotype ( 30696823) Crohn's disease ( 28067908) Granulocyte count ( 27863252) Inflammatory bowel disease ( 23128233 28067908) Joint damage in rheumatoid arthritis ( 26498133) LDL cholesterol levels ( 32203549) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Serum total protein levels ( 29403010) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Ulcerative colitis ( 28067908) White blood cell count ( 27863252)	Malaria ( 31844061)
Interacting Genes		6 interacting genes: BMPR2 LINC01554 OGT PMPCB SKIC2 ZNF76	4 interacting genes: APAF1 BCL2L1 SMURF1 UBC
Entrez ID		23203	57099
HPRD ID		07500	05588
Ensembl ID		ENSG00000165688	ENSG00000169857
Uniprot IDs		Q10713 Q5SXN9	Q9NQS1
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Receptor Localization To Synapse Regulation Of Protein Localization To Synapse	Neuron Apoptotic Process Response To G1 DNA Damage Checkpoint Signaling Mitochondrion Apoptotic Process In Bone Marrow Cell Engulfment Of Target By Autophagosome Mitochondrial Processing Peptidase Complex Apoptosome Dendritic Cell Proliferation Dendritic Cell Apoptotic Process Intrinsic Apoptotic Signaling Pathway Protein Processing Involved In Protein Targeting To Mitochondrion Regulation Of Apoptotic DNA Fragmentation Response To DNA Damage Checkpoint Signaling Cysteine-type Endopeptidase Activator Activity Response To Cycloheximide Bcl-2 Family Protein Complex Negative Regulation Of Dendritic Cell Apoptotic Process BH3 Domain Binding Negative Regulation Of Execution Phase Of Apoptosis Mitochondrial Outer Membrane Proteolysis Mitochondrial Protein Processing Activin Receptor Binding Substrate Localization To Autophagosome Cardiac Muscle Cell Apoptotic Process Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Striated Muscle Cell Apoptotic Process Apoptotic Signaling Pathway Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Protein Tag Activity Protein Targeting To Vacuole Involved In Autophagy Ectoderm Development Transforming Growth Factor Beta Receptor Binding Regulation Of Apoptotic Signaling Pathway Muscle Cell Apoptotic Process Hepatocyte Apoptotic Process Negative Regulation Of Release Of Cytochrome C From Mitochondria Ectopic Germ Cell Programmed Cell Death Mitochondrial Matrix Negative Regulation Of Anoikis I-SMAD Binding Negative Regulation Of Activin Receptor Signaling Pathway Receptor Catabolic Process Negative Regulation Of Mitochondrial Membrane Permeability Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Mitochondrial Inner Membrane Negative Regulation Of Membrane Permeability Positive Regulation Of Dendrite Extension
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