ASS1

Gene Name		argininosuccinate synthase 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrial Outer Membrane Lysosome Endoplasmic Reticulum Cytosol Perikaryon Extracellular Vesicular Exosome Cell Body Fiber
	Molecular Function	Argininosuccinate Synthase Activity Protein Binding ATP Binding Toxic Substance Binding Amino Acid Binding Poly(A) RNA Binding
	Biological Process	Urea Cycle Citrulline Metabolic Process Argininosuccinate Metabolic Process Kidney Development Liver Development Arginine Biosynthetic Process Aspartate Metabolic Process Acute-phase Response Midgut Development Aging Response To Nutrient Response To Zinc Ion Response To Mycotoxin Response To Estradiol Cellular Nitrogen Compound Metabolic Process Response To Drug Small Molecule Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Response To Growth Hormone Diaphragm Development Cellular Response To Lipopolysaccharide Cellular Response To Amino Acid Stimulus Cellular Response To Ammonium Ion Cellular Response To CAMP Cellular Response To Interferon-gamma Cellular Response To Tumor Necrosis Factor Cellular Response To Glucagon Stimulus Cellular Response To Oleic Acid Cellular Response To Amine Stimulus Cellular Response To Laminar Fluid Shear Stress Cellular Response To Dexamethasone Stimulus Negative Regulation Of Leukocyte Cell-cell Adhesion
Pathways		Urea cycle Metabolism of amino acids and derivatives
Drugs		L-Arginine L-Aspartic Acid L-Citrulline Adenosine triphosphate
Diseases
GWAS
Protein-protein Interactions		12 interactors: AKTIP APP ARAF ASCC2 ELN JAK2 MLH1 MT2A PTPN1 TERF1 TERF2 USP4
Entrez ID		445
HPRD ID		04590
Ensembl ID		ENSG00000130707
Uniprot IDs		B4E395 P00966 Q5T6L4
PDB IDs		2NZ2
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Telomeric Loop Formation Age-dependent Telomere Shortening Telomere Maintenance Via Telomere Shortening Replicative Cell Aging Regulation Of Nuclear Cell Cycle DNA Replication Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Proteolysis Negative Regulation Of DNA Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Interferon-gamma-mediated Signaling Pathway Regulation Of Telomere Maintenance Cellular Copper Ion Homeostasis Cellular Response To Interferon-gamma RNA-dependent DNA Replication Regulation Of Interferon-gamma-mediated Signaling Pathway Copper Ion Homeostasis JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Response To Interferon-gamma Growth Hormone Receptor Signaling Pathway Response To Interferon-gamma Cellular Response To Growth Hormone Stimulus Regulation Of Protein Phosphorylation Telomere Maintenance Via Telomere Lengthening Regulation Of Proteasomal Protein Catabolic Process Cellular Component Assembly Response To Growth Hormone Regulation Of Binding Immune Response Negative Regulation Of Cellular Metabolic Process Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of DNA Replication Regulation Of Cellular Process Regulation Of Phosphorylation Organelle Organization Regulation Of Metabolic Process JAK-STAT Cascade Homeostatic Process Regulation Of Phosphorus Metabolic Process Innate Immune Response Negative Regulation Of Cellular Protein Metabolic Process Histone H3-Y41 Phosphorylation Meiotic Metaphase I Plate Congression Host Programmed Cell Death Induced By Symbiont Meiotic Spindle Midzone Assembly Peptidyl-tyrosine Dephosphorylation Involved In Inactivation Of Protein Kinase Activity Cellular Localization Cell Aging
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