PMPCA and SCUBE1

		PMPCA	SCUBE1
Description		peptidase, mitochondrial processing subunit alpha	signal peptide, CUB domain and EGF like domain containing 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Membrane Mitochondrial Processing Peptidase Complex	Extracellular Region Extracellular Space Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane
	Molecular Function	Metalloendopeptidase Activity Protein Binding Metal Ion Binding	Calcium Ion Binding Protein Binding Identical Protein Binding
	Biological Process	Proteolysis Protein Processing Involved In Protein Targeting To Mitochondrion Protein Processing	Inflammatory Response Signal Transduction Adult Heart Development Blood Coagulation Post-embryonic Development Endothelial Cell Differentiation Positive Regulation Of Smoothened Signaling Pathway
Pathways		Mitochondrial protein import Processing of SMDT1 Mitochondrial protein degradation	Degradation of the extracellular matrix
Drugs
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Chronotype ( 30696823) Crohn's disease ( 28067908) Granulocyte count ( 27863252) Inflammatory bowel disease ( 23128233 28067908) Joint damage in rheumatoid arthritis ( 26498133) LDL cholesterol levels ( 32203549) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Serum total protein levels ( 29403010) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Ulcerative colitis ( 28067908) White blood cell count ( 27863252)	Appendicular lean mass ( 33097823) Blood protein levels ( 30072576) Molar-incisor hypomineralization ( 23918034) Response to fenofibrate (adiponectin levels) ( 23149075) Sensory peripheral neuropathy in microtubule targeting agent-treated breast cancer ( 32562552) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		6 interacting genes: BMPR2 LINC01554 OGT PMPCB SKIC2 ZNF76	2 interacting genes: SCUBE2 SCUBE3
Entrez ID		23203	80274
HPRD ID		07500	18029
Ensembl ID		ENSG00000165688	ENSG00000159307
Uniprot IDs		Q10713 Q5SXN9	A0JP65 Q6ZS56 Q86TI6 Q8IWY4
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Receptor Localization To Synapse Regulation Of Protein Localization To Synapse	Protein Processing Involved In Protein Targeting To Mitochondrion Extracellular Space Mitochondrial Processing Peptidase Complex Mitochondrial Protein Processing TORC2 Complex BMP Receptor Binding TORC2 Signaling
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