FAM168A and LASP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FAM168A	LASP1
Description		family with sequence similarity 168 member A	LIM and SH3 protein 1
Image		No pdb structure
GO Annotations	Cellular Component		Cytoplasm Cytoskeleton Focal Adhesion Cell Cortex Cortical Actin Cytoskeleton Postsynapse
	Molecular Function	Protein Binding	Actin Binding Protein Binding Monoatomic Ion Transmembrane Transporter Activity Cadherin Binding Metal Ion Binding Actin Filament Binding
	Biological Process	Positive Regulation Of Base-excision Repair	Monoatomic Ion Transport Monoatomic Ion Transmembrane Transport
Pathways
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Diastolic blood pressure ( 30224653) Heel bone mineral density ( 30598549) Lung function (FEV1/FVC) ( 30061609) Platelet count ( 32888494) Pulmonary function (smoking interaction) ( 23284291) Refractive error ( 32231278) Waist-hip ratio ( 28552196)	Cognitive decline rate in late mild cognitive impairment ( 26252872) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912)
Interacting Genes		77 interacting genes: AKT1 ALKBH4 ATXN1 ATXN1L BOLL C10orf55 C1orf94 CALCOCO2 CAMK2A DAB1 DAZAP2 DCUN1D1 DTX2 EPN2 EPN3 FAM168B FBXW5 HGS HIP1 HR KLHL42 KRTAP19-1 KRTAP19-5 KRTAP19-7 KRTAP3-1 KRTAP3-3 KRTAP6-2 KRTAP7-1 KRTAP8-1 LASP1 MEIS2 NAF1 NFYC OTUB2 OTULIN PATZ1 PEF1 PITX1 PLEKHB2 PROP1 PRR20A PRR20B PRR20C PRR20D PRR20E PSORS1C1 R3HDM2 RBFOX1 RBPMS RBPMS2 RHOXF2 RNF216 RPS27A SECISBP2 SF1 SMAP2 SNRPC SS18L1 TAX1BP1 TFAP2D TFG TIAL1 TNIP1 TNK1 TOLLIP UBA52 UBAC1 UBASH3B UBB UBC UBE2V1 UBQLN2 UBXN6 UBXN7 VPS37C YOD1 YTHDF1	121 interacting genes: ACD ACTA1 ACTB ACTC1 ACTMAP ANKS1A ARHGEF15 ARHGEF16 ARID5A ATXN1 BAG4 BAHD1 BHLHE40 C14orf119 CAMK2A CATSPER1 CDK7 CEBPA CERCAM CHERP COPS5 CRK CRYBA1 CRYBA2 CSTF2T CTNNA3 CYSRT1 DAZAP2 DMRT3 DNMT1 DOK6 DRC4 DTX2 EHMT2 EVX2 FAM168A FAM168B FBXO17 FHL3 FOXH1 FXR2 GCM2 GOLGA2 GUCD1 HGS HNRNPF HOXA1 INTS11 KRTAP10-8 KRTAP12-4 KRTAP19-3 KRTAP19-4 KRTAP19-6 KRTAP26-1 KRTAP3-2 KRTAP3-3 KRTAP4-2 KRTAP6-2 LENG8 LMO4 LZTS2 MDFI MED25 MGAT5B MKRN3 NOXA1 NUTF2 OTX1 OXER1 PITX1 PLSCR1 POLD1 POT1 POU1F1 PRKAR2B PRKG1 PRKG2 PRR20A PRR20B PRR20C PRR20D PRR20E PRR35 PSMA3 QRICH1 RBFOX1 RBPMS RBPMS2 REL RHOXF2 RNF38 SAXO4 SEPTIN3 SPAG8 SPRY2 STAT3 TCF4 TEKT3 TEKT4 TEKT5 TERF1 TFG THAP1 TINF2 TLX3 TNS2 TRIM27 TRIP13 UFSP1 UHRF1 VAC14 VEZF1 VGLL3 VPS37C WWOX YES1 YTHDF1 ZBTB9 ZC2HC1A ZC3H10 ZYX
Entrez ID		23201	3927
HPRD ID		13792	04229
Ensembl ID		ENSG00000054965	ENSG00000002834
Uniprot IDs		Q92567	B4DIC4 Q14847
PDB IDs			3I35
Enriched GO Terms of Interacting Partners?		Protein Tag Activity Intermediate Filament Post-translational Protein Modification Ubiquitin Protein Ligase Binding Protein Binding Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein Ubiquitination Cytoplasmic Stress Granule Modification-dependent Protein Catabolic Process Endocytic Vesicle Membrane Positive Regulation Of Post-translational Protein Modification Macromolecule Catabolic Process Autophagy Proteolysis Regulation Of Post-translational Protein Modification POZ Domain Binding Cytosol Positive Regulation Of Protein Monoubiquitination Identical Protein Binding Protein Modification Process Regulation Of Protein Monoubiquitination Glutamate Receptor Binding Clathrin-coated Vesicle Ubiquitin Conjugating Enzyme Binding RNA Stabilization Clathrin Binding Clathrin Vesicle Coat Regulation Of MRNA Metabolic Process Protein Metabolic Process Catabolic Process Endosome Transport Via Multivesicular Body Sorting Pathway Macroautophagy Negative Regulation Of RNA Catabolic Process Cytoplasm Positive Regulation Of Macromolecule Metabolic Process MRNA Binding Protein K11-linked Deubiquitination RNA Binding Vesicle Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Positive Regulation Of Translational Initiation Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Multivesicular Body Sorting Pathway Ubiquitin Binding Proteasomal Protein Catabolic Process	Identical Protein Binding Protein Binding Shelterin Complex Regulation Of Nucleobase-containing Compound Metabolic Process Intermediate Filament Nuclear Telomere Cap Complex Axonemal A Tubule Inner Sheath Positive Regulation Of Nucleobase-containing Compound Metabolic Process Telomere Capping Telomere Assembly Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Sperm Flagellum Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Flagellated Sperm Motility Sperm Motility Cilium-dependent Cell Motility Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cilium Movement Involved In Cell Motility Telomeric DNA Binding Neuron Fate Specification Regulation Of Macromolecule Metabolic Process CGMP-dependent Protein Kinase Activity Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Cytoplasmic Stress Granule DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of DNA Biosynthetic Process Chromatin Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Nucleus DNA Binding Positive Regulation Of Metabolic Process Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Negative Regulation Of Telomere Maintenance Regulation Of Metabolic Process Cilium Movement Negative Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Via Telomerase Transcription Regulator Complex Mesenchyme Migration
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