FAM168A and SECISBP2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FAM168A	SECISBP2
Description		family with sequence similarity 168 member A	SECIS binding protein 2
Image		No pdb structure
GO Annotations	Cellular Component		Nucleus Nucleoplasm Mitochondrion Ribonucleoprotein Complex
	Molecular Function	Protein Binding	DNA Binding RNA Binding MRNA 3'-UTR Binding Protein Binding Selenocysteine Insertion Sequence Binding Ribonucleoprotein Complex Binding
	Biological Process	Positive Regulation Of Base-excision Repair	Selenocysteine Incorporation RNA Catabolic Process Translation Striatum Development Forebrain Neuron Development MRNA Stabilization Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Pathways			Selenocysteine synthesis
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Diastolic blood pressure ( 30224653) Heel bone mineral density ( 30598549) Lung function (FEV1/FVC) ( 30061609) Platelet count ( 32888494) Pulmonary function (smoking interaction) ( 23284291) Refractive error ( 32231278) Waist-hip ratio ( 28552196)	Trunk fat mass ( 28552196)
Interacting Genes		77 interacting genes: AKT1 ALKBH4 ATXN1 ATXN1L BOLL C10orf55 C1orf94 CALCOCO2 CAMK2A DAB1 DAZAP2 DCUN1D1 DTX2 EPN2 EPN3 FAM168B FBXW5 HGS HIP1 HR KLHL42 KRTAP19-1 KRTAP19-5 KRTAP19-7 KRTAP3-1 KRTAP3-3 KRTAP6-2 KRTAP7-1 KRTAP8-1 LASP1 MEIS2 NAF1 NFYC OTUB2 OTULIN PATZ1 PEF1 PITX1 PLEKHB2 PROP1 PRR20A PRR20B PRR20C PRR20D PRR20E PSORS1C1 R3HDM2 RBFOX1 RBPMS RBPMS2 RHOXF2 RNF216 RPS27A SECISBP2 SF1 SMAP2 SNRPC SS18L1 TAX1BP1 TFAP2D TFG TIAL1 TNIP1 TNK1 TOLLIP UBA52 UBAC1 UBASH3B UBB UBC UBE2V1 UBQLN2 UBXN6 UBXN7 VPS37C YOD1 YTHDF1	9 interacting genes: APP ATXN7L3 DMRTB1 FAM168A GOLGA2 QKI RNF10 SMAD9 TRNAU1AP
Entrez ID		23201	79048
HPRD ID		13792	07408
Ensembl ID		ENSG00000054965	ENSG00000187742
Uniprot IDs		Q92567	A0A1S5UZH3 B4DR97 B4DZC7 Q96T21 Q9H948
PDB IDs			7ZJW 7ZJX
Enriched GO Terms of Interacting Partners?		Protein Tag Activity Intermediate Filament Post-translational Protein Modification Ubiquitin Protein Ligase Binding Protein Binding Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein Ubiquitination Cytoplasmic Stress Granule Modification-dependent Protein Catabolic Process Endocytic Vesicle Membrane Positive Regulation Of Post-translational Protein Modification Macromolecule Catabolic Process Autophagy Proteolysis Regulation Of Post-translational Protein Modification POZ Domain Binding Cytosol Positive Regulation Of Protein Monoubiquitination Identical Protein Binding Protein Modification Process Regulation Of Protein Monoubiquitination Glutamate Receptor Binding Clathrin-coated Vesicle Ubiquitin Conjugating Enzyme Binding RNA Stabilization Clathrin Binding Clathrin Vesicle Coat Regulation Of MRNA Metabolic Process Protein Metabolic Process Catabolic Process Endosome Transport Via Multivesicular Body Sorting Pathway Macroautophagy Negative Regulation Of RNA Catabolic Process Cytoplasm Positive Regulation Of Macromolecule Metabolic Process MRNA Binding Protein K11-linked Deubiquitination RNA Binding Vesicle Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Positive Regulation Of Translational Initiation Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Multivesicular Body Sorting Pathway Ubiquitin Binding Proteasomal Protein Catabolic Process	Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Nervous System Process Positive Regulation Of Myelination Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Myelination Positive Regulation Of Macromolecule Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of DNA-templated Transcription Amylin Binding Regulation Of RNA Biosynthetic Process Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process Internal N(7)-methylguanine-containing RNA Reader Activity Acetylcholine Receptor Activator Activity PTB Domain Binding Positive Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Collateral Sprouting In Absence Of Injury Regulation Of Translation Regulation Of Protein Import Regulation Of MiRNA Metabolic Process Regulation Of Gene Expression Endosome To Plasma Membrane Transport Vesicle Protein Tetramerization Positive Regulation Of Biosynthetic Process Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Myofibroblast Contraction Regulation Of Gliogenesis Negative Regulation Of MiRNA Catabolic Process Positive Regulation Of Base-excision Repair DUBm Complex Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of RNA Metabolic Process Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response
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