FAM168A and OTULIN

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		FAM168A	OTULIN
Gene Name		family with sequence similarity 168, member A	OTU deubiquitinase with linear linkage specificity
Image		No pdb structure
Gene Ontology Annotations	Cellular Component		Cytoplasm LUBAC Complex
	Molecular Function		Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity
	Biological Process		Sprouting Angiogenesis Proteolysis Negative Regulation Of NF-kappaB Transcription Factor Activity Innate Immune Response Negative Regulation Of Inflammatory Response Canonical Wnt Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Protein Linear Deubiquitination
Pathways
Drugs
Diseases
GWAS		Pulmonary function (interaction) ( 23284291)
Protein-Protein Interactions		22 interactors: C1orf94 CALCOCO2 DAB1 DAZAP2 DTX2 KLHL42 NAF1 OTUB2 OTULIN PRR20A R3HDM2 RBFOX1 RBPMS SF1 SMAP2 SNRPC SS18L1 TAX1BP1 TNIP1 UBASH3B UBE2V1 VPS37C	5 interactors: DAZAP2 DVL2 FAM168A UBC VCP
Entrez ID		23201	90268
HPRD ID		13792	14266
Ensembl ID		ENSG00000054965	ENSG00000154124
Uniprot IDs		Q92567	Q96BN8
PDB IDs			3ZNV 3ZNX 3ZNZ 4KSJ 4KSK 4KSL
Enriched GO Terms of Interacting Partners?		Modulation By Symbiont Of Host I-kappaB Kinase/NF-kappaB Cascade Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Intracellular Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Innate Immune Response Toll-like Receptor Signaling Pathway Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Defense Response Immune Response-regulating Signaling Pathway Gene Expression Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway MRNA Splice Site Selection Regulation Of RNA Metabolic Process Negative Regulation Of Viral Genome Replication Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling RNA Processing Cell-cell Adhesion Involved In Neuronal-glial Interactions Involved In Cerebral Cortex Radial Glia Guided Migration Protein Linear Deubiquitination Error-free Postreplication DNA Repair Negative Regulation Of ERK1 And ERK2 Cascade Spliceosomal Complex Assembly Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Gene Expression Positive Regulation Of Immune Response Regulation Of Inflammatory Response Regulation Of Nitrogen Compound Metabolic Process Regulation Of Viral Genome Replication Negative Regulation Of Viral Process Cerebellum Structural Organization Ribonucleoprotein Complex Biogenesis Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process RNA Splicing Regulation Of Nucleic Acid-templated Transcription Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Cellular Protein Metabolic Process Regulation Of Phosphorylation Lateral Motor Column Neuron Migration Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Inflammatory Response Cellular Metabolic Process Innate Immune Response Interaction With Host	Positive Regulation Of Protein Modification Process Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Protein Metabolic Process Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of MAP Kinase Activity Positive Regulation Of Protein Catabolic Process Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Catalytic Activity Protein Processing Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Convergent Extension Involved In Neural Plate Elongation Proteasomal Protein Catabolic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of MAP Kinase Activity Positive Regulation Of Proteolysis Regulation Of Wnt Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Retrograde Protein Transport, ER To Cytosol Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Deubiquitination Convergent Extension Involved In Organogenesis Regulation Of Protein Catabolic Process Protein Hexamerization Regulation Of Protein Metabolic Process Canonical Wnt Signaling Pathway Involved In Regulation Of Cell Proliferation Neural Plate Morphogenesis Positive Regulation Of MAPK Cascade Regulation Of Catalytic Activity Cellular Localization Positive Regulation Of Protein Kinase Activity Aggresome Assembly Positive Regulation Of Kinase Activity Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cellular Metabolic Process Translesion Synthesis Viral Protein Processing Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Planar Cell Polarity Pathway Involved In Neural Tube Closure Positive Regulation Of Transferase Activity Cellular Protein Catabolic Process Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure
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