FAM168A and UBE2V1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		FAM168A	UBE2V1
Gene Name		family with sequence similarity 168, member A	ubiquitin-conjugating enzyme E2 variant 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component		Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Ubiquitin Conjugating Enzyme Complex UBC13-UEV1A Complex Protein Complex Extracellular Vesicular Exosome
	Molecular Function		Protein Binding Ubiquitin-like Protein Transferase Activity Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity
	Biological Process		Protein Polyubiquitination Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of DNA Repair Postreplication Repair Regulation Of Transcription, DNA-templated Cell Differentiation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Error-free Postreplication DNA Repair Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Transcription, DNA-templated T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Protein K63-linked Ubiquitination
Pathways			Downstream TCR signaling Antigen processing: Ubiquitination & Proteasome degradation Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade IRAK1 recruits IKK complex Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade FCERI mediated NF-kB activation MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade NOD1/2 Signaling Pathway MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Class I MHC mediated antigen processing & presentation Toll Like Receptor 9 (TLR9) Cascade IRAK1 recruits IKK complex Innate Immune System TRIF-mediated TLR3/TLR4 signaling IKK complex recruitment mediated by RIP1 Cytokine Signaling in Immune system MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Signaling by Interleukins TCR signaling Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Fc epsilon receptor (FCERI) signaling Interleukin-1 signaling TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Adaptive Immune System
Drugs
Diseases
GWAS		Pulmonary function (interaction) ( 23284291)
Protein-Protein Interactions		22 interactors: C1orf94 CALCOCO2 DAB1 DAZAP2 DTX2 KLHL42 NAF1 OTUB2 OTULIN PRR20A R3HDM2 RBFOX1 RBPMS SF1 SMAP2 SNRPC SS18L1 TAX1BP1 TNIP1 UBASH3B UBE2V1 VPS37C	36 interactors: ARIH2 BIRC2 BIRC3 BIRC8 CHFR DTX3 DZIP3 FAM168A KITLG MID1 MKRN3 PARK2 PELI1 PELI3 RNF10 RNF111 RNF14 RNF144A RNF185 RNF2 RNF5 RNF8 STUB1 SUMO4 TRAF2 TRAF3IP2 TRAF6 TRIM39 TRIM5 TRIM8 UBC UBE2N UBOX5 UBQLN1 XIAP ZNRF1
Entrez ID		23201	7335
HPRD ID		13792	04294
Ensembl ID		ENSG00000054965	ENSG00000244687
Uniprot IDs		Q92567	Q13404
PDB IDs			2A4D 2C2V 2HLW
Enriched GO Terms of Interacting Partners?		Modulation By Symbiont Of Host I-kappaB Kinase/NF-kappaB Cascade Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Intracellular Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Innate Immune Response Toll-like Receptor Signaling Pathway Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Defense Response Immune Response-regulating Signaling Pathway Gene Expression Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway MRNA Splice Site Selection Regulation Of RNA Metabolic Process Negative Regulation Of Viral Genome Replication Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling RNA Processing Cell-cell Adhesion Involved In Neuronal-glial Interactions Involved In Cerebral Cortex Radial Glia Guided Migration Protein Linear Deubiquitination Error-free Postreplication DNA Repair Negative Regulation Of ERK1 And ERK2 Cascade Spliceosomal Complex Assembly Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Gene Expression Positive Regulation Of Immune Response Regulation Of Inflammatory Response Regulation Of Nitrogen Compound Metabolic Process Regulation Of Viral Genome Replication Negative Regulation Of Viral Process Cerebellum Structural Organization Ribonucleoprotein Complex Biogenesis Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process RNA Splicing Regulation Of Nucleic Acid-templated Transcription Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Cellular Protein Metabolic Process Regulation Of Phosphorylation Lateral Motor Column Neuron Migration Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Inflammatory Response Cellular Metabolic Process Innate Immune Response Interaction With Host	Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Polyubiquitination Cellular Protein Modification Process Protein K63-linked Ubiquitination Cellular Protein Metabolic Process Regulation Of Protein Ubiquitination Protein Metabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Protein K48-linked Ubiquitination Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Toll-like Receptor 4 Signaling Pathway Protein Autoubiquitination Activation Of Innate Immune Response Protein Catabolic Process Regulation Of Innate Immune Response Ubiquitin-dependent Protein Catabolic Process Regulation Of Signaling Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Innate Immune Response Toll-like Receptor Signaling Pathway Cellular Protein Catabolic Process Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Intracellular Signal Transduction Cellular Macromolecule Catabolic Process Cellular Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Cellular Protein Metabolic Process Innate Immune Response Immune Response Regulation Of Protein Metabolic Process Immune Response-regulating Signaling Pathway Positive Regulation Of Cellular Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Cellular Protein Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Catabolic Process Positive Regulation Of Protein Metabolic Process Defense Response Response To Stress
Tagcloud ?			activate autophosphorylation catalyse chains conjugated conjugating deubiquitination disassembly emanating ikk il1r lys map3k7 map3k7ip2 phosphorylates polyubiquitin polyubiquitinated polyubiquitination reconstituting tab2 tak1 toll traf6 ubc13 ubch5c ube2d3 ube2n uev1a unanchored
Tagcloud (Difference) ?			activate autophosphorylation catalyse chains conjugated conjugating deubiquitination disassembly emanating ikk il1r lys map3k7 map3k7ip2 phosphorylates polyubiquitin polyubiquitinated polyubiquitination reconstituting tab2 tak1 toll traf6 ubc13 ubch5c ube2d3 ube2n uev1a unanchored
Tagcloud (Intersection) ?