PHLDB1 and TSC2

Number of citations of the paper that reports this interaction (PubMedID 21653829)
54

Data Source:
BioGRID (two hybrid)

		PHLDB1	TSC2
Description		pleckstrin homology like domain family B member 1	TSC complex subunit 2
Image		No pdb structure
GO Annotations	Cellular Component	Basal Cortex	Nucleus Cytoplasm Lysosome Lysosomal Membrane Golgi Apparatus Cytosol Postsynaptic Density Membrane TSC1-TSC2 Complex Synapse Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding	GTPase Activator Activity Protein Binding Phosphatase Binding Small GTPase Binding Protein Homodimerization Activity Hsp90 Protein Binding
	Biological Process	Basement Membrane Organization	Neural Tube Closure Cytoplasmic Translation Protein Import Into Nucleus Endocytosis Heart Development Intracellular Protein Localization Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation Vesicle-mediated Transport Positive Regulation Of Macroautophagy Regulation Of Macroautophagy Regulation Of Endocytosis Negative Regulation Of Wnt Signaling Pathway Cellular Response To Nutrient Levels Negative Regulation Of TOR Signaling TORC1 Signaling Anoikis Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Insulin Receptor Signaling Pathway Positive Chemotaxis Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cell Cycle Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Mitophagy Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling
Pathways			Macroautophagy Inhibition of TSC complex formation by PKB AKT phosphorylates targets in the cytosol Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer TBC/RABGAPs
Drugs
Diseases			Lymphangioleiomyomatosis (LAM) Tuberous sclerosis complex (TSC); Bourneville-Pringle disease
GWAS		Adult diffuse glioma (IDH mutation) ( 32386320) Adult diffuse glioma (IDH mutation, 1p/19q non-codeleted) ( 32386320) Age-related hearing impairment ( 34108613) Celiac disease ( 25920553) Cholesterol, total ( 24097068) Glioma ( 29743610 30714141 19578367 28346443 21531791) Heel bone mineral density ( 28869591 30598549) Multiple sclerosis ( 31604244) Non-glioblastoma glioma ( 28346443 29743610) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 29403010 33339817) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Total cholesterol levels ( 30275531 28334899) Vitiligo ( 22951725)	Major depressive disorder ( 29317602) Obesity-related traits ( 23251661) White blood cell count ( 32888494)
Interacting Genes		6 interacting genes: FXR1 FXR2 SHANK3 SRPK2 TSC1 TSC2	61 interacting genes: ACTN2 AKT1 AKT2 AKT3 ANKRD35 BTG3 CALM1 CBY2 CCND1 CDKN1B EEF1A1 ESR1 FBXL6 FBXW5 GAPDH GRB2 GSK3B LNX1 MAPK1 MAPK3 MAPKAPK2 MDFI MKRN1 MRPL21 NEK1 PAM PHLDB1 PICK1 PIN1 PLK2 PPP1CA PPP2CA PRKAA1 PTK2 PTPN11 RAB5A RABEP1 RHEB RPL4 RPS6KA1 RPSA SEPTIN4 SERPINI1 SFN SLC13A3 SMAD2 SMAD3 SSC4D SUPT6H TK1 TRIM55 TRIM63 TSC1 UBE3A USPL1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		23187	7249
HPRD ID		15128	01850
Ensembl ID		ENSG00000019144	ENSG00000103197
Uniprot IDs		Q6ZUD6 Q86UU1 Q8NC75	A0A2R8Y6C9 A0A2R8YDZ2 B3KWH7 H3BMQ0 P49815 Q5HYF7 X5D2U8 X5D7Q2
PDB IDs			7DL2 9CE3
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Long-term Neuronal Synaptic Plasticity TSC1-TSC2 Complex Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Translation Translation Regulator Activity Regulation Of Synaptic Plasticity Dentate Gyrus Development Positive Regulation Of Neurogenesis Presynapse Postsynaptic Density Negative Regulation Of Macroautophagy Hsp90 Protein Binding Presynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Nervous System Development Regulation Of Long-term Synaptic Potentiation Synapse Regulation Of MRNA Metabolic Process Neuron Projection Regulation Of Neurogenesis Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Negative Regulation Of Catabolic Process TORC1 Signaling Regulation Of Translation Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Gene Expression Memory T Cell Differentiation Regulation Of Cell Size TOR Signaling Neural Tube Closure Positive Regulation Of Cell Development Cytoplasmic Ribonucleoprotein Granule Regulation Of Nervous System Development Nucleus Organization Positive Regulation Of TOR Signaling Tube Closure Negative Regulation Of TOR Signaling Cytoplasmic Stress Granule Modulation Of Chemical Synaptic Transmission Regulation Of TORC1 Signaling Associative Learning MRNA Destabilization RNA Destabilization Negative Regulation Of Autophagy Animal Organ Development Positive Regulation Of Catabolic Process Positive Regulation Of MRNA Catabolic Process Developmental Process	Intracellular Signal Transduction Protein Modification Process Protein Metabolic Process Phosphoserine Residue Binding Regulation Of TOR Signaling Cytosol TOR Signaling Negative Regulation Of TOR Signaling Protein Kinase Binding Cytoplasm TORC1 Signaling Regulation Of Intracellular Signal Transduction Regulation Of Biological Quality Intracellular Signaling Cassette Regulation Of Cell Communication Regulation Of Signaling Regulation Of TORC1 Signaling Negative Regulation Of TORC1 Signaling Regulation Of Signal Transduction Protein Domain Specific Binding Macromolecule Metabolic Process Cellular Response To Stress Protein Sequestering Activity Ciliary Basal Body Identical Protein Binding Insulin Receptor Signaling Pathway Signal Transduction Protein Kinase Activity Cellular Response To Nutrient Levels Positive Regulation Of TOR Signaling Kinase Activity Protein Phosphorylation Protein Serine Kinase Activity Regulation Of Synaptic Plasticity SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Signal Transduction Regulation Of Protein Stability Negative Regulation Of Catabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Organelle Organization Epidermal Growth Factor Receptor Signaling Pathway Phosphorylation Negative Regulation Of Signaling Positive Regulation Of TORC1 Signaling Negative Regulation Of Cell Communication Nucleus Regulation Of Immune Response Regulation Of Protein Metabolic Process Protein Serine/threonine Kinase Activity
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