CLCC1 and GHR

		CLCC1	GHR
Description		chloride channel CLIC like 1	growth hormone receptor
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Chloride Channel Complex Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site	Extracellular Region Extracellular Space Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Cytoplasmic Ribonucleoprotein Granule Neuronal Cell Body Receptor Complex Growth Hormone Receptor Complex
	Molecular Function	Chloride Channel Activity Protein Binding	Cytokine Receptor Activity Growth Hormone Receptor Activity Protein Binding Lipid Binding Peptide Hormone Binding Growth Factor Binding Protein Kinase Binding Protein Phosphatase Binding Cytokine Binding Protein Tyrosine Kinase Activator Activity SH2 Domain Binding Identical Protein Binding Protein Homodimerization Activity Proline-rich Region Binding Protein Tyrosine Kinase Binding
	Biological Process	Monoatomic Ion Transport Chloride Transport Endoplasmic Reticulum Calcium Ion Homeostasis Monoatomic Ion Transmembrane Transport Chloride Transmembrane Transport	Endocytosis Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Population Proliferation Response To Gravity Response To Hormone Hormone-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Taurine Metabolic Process Receptor Internalization Response To Food Regulation Of Response To Nutrient Levels Response To Estradiol Cellular Response To Insulin Stimulus Cellular Response To Hormone Stimulus Response To Cytokine Regulation Of Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Hormone Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of MAPK Cascade Response To Peptide Hormone Positive Regulation Of Cell Differentiation Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Response To Cycloheximide Insulin-like Growth Factor Receptor Signaling Pathway Response To Glucocorticoid Cartilage Development Involved In Endochondral Bone Morphogenesis Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Growth Hormone Receptor Signaling Pathway Response To Growth Hormone Response To Interleukin-1
Pathways			Prolactin receptor signaling Growth hormone receptor signaling Growth hormone receptor signaling
Drugs			Somatotropin Pegvisomant Somatrem Somapacitan Lonapegsomatropin
Diseases			Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS		Fat distribution (HIV) ( 21897333) Recurrent major depressive disorder ( 29317602)	Appendicular lean mass ( 33097823) Blood protein levels ( 30072576) Familial squamous cell lung carcinoma ( 29924316) Heel bone mineral density ( 30598549) Height ( 25429064 28552196 31562340) Hip circumference adjusted for BMI ( 34021172) Iron status biomarkers ( 19084217) Menarche (age at onset) ( 25231870) Plasma renin activity levels ( 29650764) Response to taxane treatment (docetaxel) ( 23006423) Systemic lupus erythematosus ( 18204098)
Interacting Genes		1 interacting genes: OGT	44 interacting genes: AP2A1 BTRC CISH CUL1 CUL5 DUSP7 ELOB ELOC FBXO31 GH1 GH2 GRB10 GRB2 IRS1 JAK1 JAK2 NCOA6 NEDD8 PIK3R1 PIK3R2 PLCG1 PTPN1 PTPN11 PTPN13 PTPN2 PTPN3 PTPN6 PTPN9 PTPRB PTPRH RBX1 RNF7 SGTA SHC1 SKP1 SOCS1 SOCS2 SOCS3 SRPK2 STAT3 STAT5A STAT5B STUB1 TYK2
Entrez ID		23155	2690
HPRD ID		17471	02971
Ensembl ID		ENSG00000121940	ENSG00000112964
Uniprot IDs		A0A6Q8PG14 Q96S66	A0A087X0H5 A0A087X162 P10912
PDB IDs			1A22 1AXI 1HWG 1HWH 1KF9 2AEW 3HHR 5OEK 5OHD 6I5J 6I5N
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transcription By Glucose Cellular Response To Nutrient Regulation Of Glycolytic Process Protein Localization To Lysosome Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Carbohydrate Catabolic Process Positive Regulation Of TORC1 Signaling Regulation Of Protein Localization TORC1 Signaling Detection Of Hot Stimulus Involved In Thermoception Carbohydrate Response Element Binding Regulation Of ATP Metabolic Process TOR Signaling Regulation Of Purine Nucleotide Metabolic Process Positive Regulation Of TOR Signaling Growth Hormone Receptor Activity Protein Localization To Vacuole Positive Regulation Of Lipid Biosynthetic Process Regulation Of TORC1 Signaling Positive Regulation Of Protein Localization Lateral Cell Cortex ADP:phosphate Antiporter Activity Response To Nutrient Levels Growth Hormone Receptor Complex Protein O-acetylglucosaminyltransferase Activity Cell Cortex Region ATP:phosphate Antiporter Activity Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Lipid Metabolic Process Adenine Nucleotide Transmembrane Transporter Activity Response To Cycloheximide Response To Insulin Regulation Of TOR Signaling Non-canonical Inflammasome Complex Assembly Regulation Of Protein Localization To Cell Periphery Protein Localization To Organelle Response To Nutrient Ragulator Complex Detection Of Temperature Stimulus Involved In Thermoception Regulation Of Microtubule Cytoskeleton Organization Anterior Commissure Morphogenesis Maintenance Of Centrosome Location Positive Regulation Of Protein Localization To Cell Cortex Glucose Mediated Signaling Pathway Regulation Of Biological Quality	Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Modification Process Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Phosphotyrosine Residue Binding Cell Surface Receptor Signaling Pathway Via STAT Cytosol Protein Dephosphorylation Growth Hormone Receptor Binding Protein Tyrosine Phosphatase Activity Peptidyl-tyrosine Dephosphorylation Signal Transduction Protein Metabolic Process Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Cell Communication Negative Regulation Of Signaling Insulin Receptor Signaling Pathway Negative Regulation Of Signal Transduction Macromolecule Metabolic Process Cul5-RING Ubiquitin Ligase Complex Dephosphorylation Phosphoprotein Phosphatase Activity Regulation Of Signal Transduction Negative Regulation Of Growth Hormone Receptor Signaling Pathway Erythropoietin-mediated Signaling Pathway Regulation Of Insulin Receptor Signaling Pathway Regulation Of Cellular Response To Insulin Stimulus Protein Ubiquitination Insulin Receptor Binding Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Cellular Response To Insulin Stimulus Regulation Of Growth Hormone Receptor Signaling Pathway Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Modification By Small Protein Conjugation Regulation Of Signaling Regulation Of Cell Communication Post-translational Protein Modification SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Insulin-like Growth Factor Receptor Binding Neurotrophin TRKA Receptor Binding Regulation Of Cell Adhesion Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cytoplasm
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