RAD54L2 and SUMO3

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		RAD54L2	SUMO3
Description		RAD54 like 2	small ubiquitin like modifier 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Body	Kinetochore Nucleus Nucleoplasm Cytoplasm PML Body
	Molecular Function	Nucleotide Binding DNA Binding Transcription Coregulator Activity Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity ATP-dependent Chromatin Remodeler Activity	Protein Binding Protein Tag Activity Ubiquitin-like Protein Ligase Binding
	Biological Process	Chromatin Organization Chromatin Remodeling Positive Regulation Of Transcription By RNA Polymerase II	Protein Sumoylation Negative Regulation Of DNA Binding Regulation Of Protein Localization To Nucleus
Pathways			SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is proteolytically processed SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors SUMOylation of transcription cofactors SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins SUMOylation of DNA replication proteins SUMOylation of immune response proteins Formation of Incision Complex in GG-NER
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31152163)	Delirium ( 29631748)
Interacting Genes		44 interacting genes: AR ATN1 ATXN1 ATXN1L BANP BHLHE40 CBX3 CRK FAM118B FXR2 HMG20A HNRNPCL1 HOMER1 IMPDH1 KIFC3 KRTAP6-3 LCE1D LCE1F NR3C1 NR5A1 NR5A2 PAICS PIAS1 POU1F1 PPARG PSMA3 RAD51 RBPMS RUNX1T1 RXRA SIAH1 SQSTM1 SUMO1 SUMO2 SUMO3 TAX1BP1 TFAP2D THAP1 TRAF2 TRAF4 UBE2I VCX ZBTB26 ZC2HC1A	62 interacting genes: ANXA7 BLM CCNE2 CDKN1A CEBPA CHAF1A COPS5 CUL3 DAXX EGLN3 FAM221A FOS HIPK1 HIPK2 HOMEZ HSF1 HSF2 JUN KALRN MAPKAPK3 MORC3 PAX6 PCGF2 PFDN1 PIAS1 PIAS2 PIAS3 PIAS4 PML RAD54L2 RANGAP1 RNF111 RNF8 SAE1 SENP1 SENP2 SENP5 SMN1 SNRNP70 SOX10 SOX6 SP100 TDG TDP2 TK1 TP53BP2 TTR UBA2 UBE2I UBE3A UPF2 USP25 USPL1 VIM WWTR1 YAP1 ZBTB33 ZBTB39 ZCCHC12 ZMYM2 ZNF451 ZNF496
Entrez ID		23132	6612
HPRD ID		10018	03754
Ensembl ID		ENSG00000164080	ENSG00000184900
Uniprot IDs		B3KV54 Q9Y4B4	P55854
PDB IDs			1U4A 2IO1 2MP2 6K5R 6NNQ 7R2E 7ZJU
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Enzyme Binding PML Body Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Transcription Coregulator Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Receptor Activity Nucleus Postsynaptic Cytosol Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nucleobase-containing Compound Biosynthetic Process Protein Sumoylation Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process Transcription By RNA Polymerase II 'de Novo' XMP Biosynthetic Process Presynaptic Cytosol Ubiquitin Protein Ligase Binding Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Intracellular Receptor Signaling Pathway Signaling Adaptor Activity Hormone-mediated Signaling Pathway Chromatin Regulation Of Primary Metabolic Process Chromatin Binding GMP Biosynthetic Process IMP Dehydrogenase Activity DNA-binding Transcription Factor Activity Negative Regulation Of Metabolic Process Protein Tag Activity Purine Ribonucleoside Monophosphate Biosynthetic Process Zinc Ion Binding Regulation Of Gene Expression SUMO Transferase Activity Sequence-specific DNA Binding Double-stranded DNA Binding RNA Polymerase II Transcription Regulator Complex Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process	PML Body Protein Sumoylation Nucleus Nucleoplasm Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Protein Modification By Small Protein Conjugation Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Post-translational Protein Modification Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Protein Modification Process Regulation Of Transcription By RNA Polymerase II SUMO Transferase Activity Regulation Of Gene Expression Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process SUMO Binding SMAD Protein Signal Transduction Cellular Response To Stress SUMO Ligase Activity Positive Regulation Of Protein Sumoylation Postsynaptic Cytosol Ubiquitin Protein Ligase Binding Macromolecule Metabolic Process Regulation Of Post-translational Protein Modification Positive Regulation Of Post-translational Protein Modification Transcription Corepressor Activity Positive Regulation Of Macromolecule Metabolic Process DeSUMOylase Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA Damage Response Regulation Of Protein Sumoylation Protein Desumoylation Transcription Coregulator Activity Chromatin Positive Regulation Of RNA Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Presynaptic Cytosol
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