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RAD54L2 and PSMA3
Number of citations of the paper that reports this interaction (PubMedID
25416956
)
56
Data Source:
BioGRID
(two hybrid)
RAD54L2
PSMA3
Description
RAD54 like 2
proteasome 20S subunit alpha 3
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nuclear Body
Proteasome Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Proteasome Core Complex
Proteasome Core Complex, Alpha-subunit Complex
Extracellular Exosome
Molecular Function
Nucleotide Binding
DNA Binding
Transcription Coregulator Activity
Helicase Activity
Protein Binding
ATP Binding
Hydrolase Activity
ATP Hydrolysis Activity
ATP-dependent Chromatin Remodeler Activity
Protein Binding
Ubiquitin Protein Ligase Binding
Biological Process
Chromatin Organization
Chromatin Remodeling
Positive Regulation Of Transcription By RNA Polymerase II
Ubiquitin-dependent Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Pathways
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
Assembly of the pre-replicative complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
KEAP1-NFE2L2 pathway
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
Degradation of CDH1
Somitogenesis
Antigen processing: Ubiquitination & Proteasome degradation
Proteasome assembly
Proteasome assembly
Antigen processing: Ub, ATP-independent proteasomal degradation
GSK3B-mediated proteasomal degradation of PD-L1(CD274)
SPOP-mediated proteasomal degradation of PD-L1(CD274)
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Degradation of CRY and PER proteins
Degradation of CRY and PER proteins
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE
Phenethyl Isothiocyanate
Diseases
GWAS
Estimated glomerular filtration rate (
31152163
)
Brain morphology (MOSTest) (
32665545
)
Mean corpuscular hemoglobin (
27863252
)
Mean corpuscular volume (
27863252
)
Red blood cell count (
32888494
)
Interacting Genes
44 interacting genes:
AR
ATN1
ATXN1
ATXN1L
BANP
BHLHE40
CBX3
CRK
FAM118B
FXR2
HMG20A
HNRNPCL1
HOMER1
IMPDH1
KIFC3
KRTAP6-3
LCE1D
LCE1F
NR3C1
NR5A1
NR5A2
PAICS
PIAS1
POU1F1
PPARG
PSMA3
RAD51
RBPMS
RUNX1T1
RXRA
SIAH1
SQSTM1
SUMO1
SUMO2
SUMO3
TAX1BP1
TFAP2D
THAP1
TRAF2
TRAF4
UBE2I
VCX
ZBTB26
ZC2HC1A
120 interacting genes:
ADGRL1
APLN
ATN1
ATP6V0C
AURKB
BTN2A2
BTRC
C1orf105
CCDC69
CCL28
CDK6
CDKN1A
CEBPA
CIP2A
CRB3
CRYAB
CSNK2A1
CST2
CTBP1-DT
CYBA
DDX5
DGLUCY
DMC1
DMRT3
DVL1
EGR1
FAM171A2
FAM218A
FAM83A
FBXL18
FNDC3B
FOS
FRAT1
GATA2
GATA3
GFI1B
GORASP2
HHEX
HSPB1
IKBKG
ILF3
IQCE
KIF1A
KIRREL2
KIRREL3-AS3
KRAS
KRTAP19-5
KRTAP26-1
KRTAP8-1
LASP1
LBP
LETM1
LINC00908
LINC02913
MDM2
MIA2
NEU4
NOL4L-DT
NPBWR2
NPPB
NUMBL
OLIG2
OSR2
PATL1
PCOTH
PLK1
PML
POMP
PRELID3A
PRNP
PRR13
PRR3
PRRC2A
PSMA1
PSMA2
PSMA4
PSMA6
PSMA7
PSMB10
PSMB5
PTPN23
PWWP2B
PWWP3A
RAB3IL1
RAD54L2
RAMAC
RBFOX2
RERE
RFT1
RTP5
RUSC1-AS1
SERF2
SF1
SH3KBP1
SLAIN1
SLC22A23
SNRPB
SNRPC
SNRPF
SPATA8
SRPK2
STUB1
STX11
STX1A
STX4
STX6
TBC1D16
TBX6
TCF7L2
TINCR
TP53
TRIB3
UBD
URB1-AS1
VPS37C
XRN2
YPEL3
ZNF366
ZNF385C
ZNF688
Entrez ID
23132
5684
HPRD ID
10018
01463
Ensembl ID
ENSG00000164080
ENSG00000100567
Uniprot IDs
B3KV54
Q9Y4B4
A0A140VK43
P25788
PDB IDs
4R3O
4R67
5A0Q
5DSV
5GJQ
5GJR
5L4G
5LE5
5LEX
5LEY
5LEZ
5LF0
5LF1
5LF3
5LF4
5LF6
5LF7
5LN3
5M32
5T0C
5T0G
5T0H
5T0I
5T0J
5VFO
5VFP
5VFQ
5VFR
5VFS
5VFT
5VFU
6AVO
6E5B
6KWY
6MSB
6MSD
6MSE
6MSG
6MSH
6MSJ
6MSK
6R70
6REY
6RGQ
6WJD
6WJN
6XMJ
7AWE
7B12
7E55
7LXV
7NAN
7NAO
7NAP
7NAQ
7NHT
7PG9
7QXN
7QXP
7QXU
7QXW
7QXX
7QY7
7QYA
7QYB
7V5G
7V5M
7W37
7W38
7W39
7W3A
7W3B
7W3C
7W3F
7W3G
7W3H
7W3I
7W3J
7W3K
7W3M
8BZL
8CVR
8CVS
8CVT
8CXB
8JRI
8JRT
8JTI
8K0G
8QYJ
8QYL
8QYM
8QYN
8QYO
8QYS
8QZ9
8TM3
8TM4
8TM5
8TM6
8UD9
8USB
8USC
8YIX
8YIY
8YIZ
9E8G
9E8H
9E8I
9E8J
9E8K
9E8L
9E8N
9E8O
9E8Q
9HMN
Enriched GO Terms of Interacting Partners
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Identical Protein Binding
Enzyme Binding
PML Body
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of RNA Biosynthetic Process
Transcription Coregulator Binding
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Nuclear Receptor Activity
Nucleus
Postsynaptic Cytosol
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
DNA Binding
DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Nucleobase-containing Compound Biosynthetic Process
Protein Sumoylation
Nucleoplasm
Negative Regulation Of Macromolecule Biosynthetic Process
Transcription By RNA Polymerase II
'de Novo' XMP Biosynthetic Process
Presynaptic Cytosol
Ubiquitin Protein Ligase Binding
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Intracellular Receptor Signaling Pathway
Signaling Adaptor Activity
Hormone-mediated Signaling Pathway
Chromatin
Regulation Of Primary Metabolic Process
Chromatin Binding
GMP Biosynthetic Process
IMP Dehydrogenase Activity
DNA-binding Transcription Factor Activity
Negative Regulation Of Metabolic Process
Protein Tag Activity
Purine Ribonucleoside Monophosphate Biosynthetic Process
Zinc Ion Binding
Regulation Of Gene Expression
SUMO Transferase Activity
Sequence-specific DNA Binding
Double-stranded DNA Binding
RNA Polymerase II Transcription Regulator Complex
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of RNA Metabolic Process
Proteasome Core Complex
Proteasome Core Complex, Alpha-subunit Complex
Response To Gamma Radiation
Proteasome Complex
Cellular Response To Gamma Radiation
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of RNA Metabolic Process
Regulation Of MiRNA Transcription
Positive Regulation Of MiRNA Transcription
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of MiRNA Metabolic Process
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of MiRNA Metabolic Process
Response To Ionizing Radiation
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Ubiquitin-dependent Protein Catabolic Process
Protein Binding
Negative Regulation Of Biosynthetic Process
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Response To Gravity
Cellular Response To Ionizing Radiation
Regulation Of Proteolysis
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Molecular Function Activator Activity
Macromolecule Catabolic Process
Negative Regulation Of Cell Cycle
Nuclear Matrix
Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Nucleoplasm
Protein Destabilization
Regulation Of Protein Stability
HMG Box Domain Binding
Proteolysis Involved In Protein Catabolic Process
Regulation Of Proteasomal Protein Catabolic Process
Positive Regulation Of Proteolysis
Regulation Of Hormone Metabolic Process
Protein Catabolic Process
Negative Regulation Of Macromolecule Metabolic Process
SNAP Receptor Activity
Proteasomal Protein Catabolic Process
Cellular Response To Actinomycin D
Promoter-specific Chromatin Binding
Positive Regulation Of Proteasomal Protein Catabolic Process
Positive Regulation Of Cellular Senescence
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Tagcloud (Difference)
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Tagcloud (Intersection)
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