SSR4 and SSR3

Number of citations: 0 (PubMedID 7916687)
Data Source: HPRD (in vitro)

		SSR4	SSR3
Name		signal sequence receptor subunit 4	signal sequence receptor subunit 3
Structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Sec61 Translocon Complex Endoplasmic Reticulum Membrane Endomembrane System Membrane Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	None	Protein Binding
	Biological Process	None	SRP-dependent Cotranslational Protein Targeting To Membrane
Pathways		SRP-dependent cotranslational protein targeting to membrane	SRP-dependent cotranslational protein targeting to membrane
GWAS		No GWAS studies recorded	Asthma (adult onset) ( 30929738 ) Chronotype ( 30696823 ) Malaria ( 31844061 ) Metabolite levels ( 23823483 ) Testicular germ cell tumor ( 28604732 )
Novel Interactors		2 novel interactors: PPP1R16B TAFAZZIN	1 novel interactors: ERBB3
Interacting Genes		5 interacting genes: HECW1 NLGN3 POMP PTEN SSR3	5 interacting genes: AQP2 PDE4B PRRC2A RABAC1 SSR4
Entrez ID		6748	6747
HPRD ID		02101	16206
Ensembl ID		ENSG00000180879	ENSG00000114850
Uniprot IDs		P51571	C9J365 Q9UNL2
PDB IDs		8B6L	8B6L
GO Terms Enriched among Interactors		Rhythmic Synaptic Transmission Presynaptic Membrane Organization Presynaptic Membrane Assembly Positive Regulation Of Excitatory Postsynaptic Potential Social Behavior Membrane Assembly Modulation Of Excitatory Postsynaptic Potential Negative Regulation Of Synaptic Vesicle Clustering Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Synapse Assembly Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Positive Regulation Of Cardiolipin Metabolic Process Regulation Of Nervous System Process Central Nervous System Myelin Maintenance Symmetric, GABA-ergic, Inhibitory Synapse Regulation Of Plasma Membrane Bounded Cell Projection Organization Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Regulation Of Cell Projection Organization Adult Behavior Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Phosphatidylinositol Phosphate Phosphatase Activity Membrane Organization Regulation Of Cardiolipin Metabolic Process Cardiolipin Acyl-chain Remodeling Asymmetric, Glutamatergic, Excitatory Synapse Locomotor Rhythm Regulation Of Cell Junction Assembly Cognition Cell Junction Assembly Chemical Synaptic Transmission Phosphatidylinositol-3-phosphate Phosphatase Activity Cellular Response To Electrical Stimulus Learning Or Memory Ubiquitin Ligase Activator Activity Spindle Assembly Involved In Female Meiosis Negative Regulation Of Peptidyl-serine Phosphorylation Regulation Of Synaptic Vesicle Clustering Glycerolipid Metabolic Process Postsynaptic Specialization Assembly Prepulse Inhibition Neuron-neuron Synaptic Transmission Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Anatomical Structure Morphogenesis Meiotic Spindle Assembly Synapse Maturation Negative Regulation Of Cell Size Maternal Behavior	Lumenal Side Of Membrane Polyol Transmembrane Transport Renal Water Transport Response To Water Deprivation Glycerol Transmembrane Transport Water Transmembrane Transporter Activity Cellular Response To Mercury Ion Metanephric Collecting Duct Development Cellular Response To Water Deprivation Glycerol Transmembrane Transporter Activity Response To Mercury Ion Basolateral Plasma Membrane Positive Regulation Of Cardiac Muscle Tissue Development ErbB-3 Class Receptor Binding ERBB3:ERBB2 Complex Neuregulin Receptor Activity ERBB2-ERBB3 Signaling Pathway Schwann Cell Differentiation ERBB3 Signaling Pathway Neuregulin Binding Regulation Of Cardiac Muscle Tissue Development Neutrophil Homeostasis Synaptic Vesicle Negative Regulation Of Relaxation Of Muscle CAMP Catabolic Process Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Negative Regulation Of Relaxation Of Cardiac Muscle Regulation Of Relaxation Of Cardiac Muscle Sec61 Translocon Complex Response To Water Negative Regulation Of Motor Neuron Apoptotic Process Gamma-tubulin Complex Membrane Collecting Duct Development Endocardial Cushion Development Cellular Response To Epinephrine Stimulus Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Water Channel Activity Regulation Of Motor Neuron Apoptotic Process Motor Neuron Apoptotic Process Cyclic Nucleotide Catabolic Process Response To Epinephrine Protein Tyrosine Kinase Activator Activity Regulation Of Relaxation Of Muscle Apical Plasma Membrane Renal Water Homeostasis Plasma Membrane Schwann Cell Development Positive Regulation Of Calcineurin-NFAT Signaling Cascade 3',5'-cyclic-AMP Phosphodiesterase Activity