WAPL and ARAP1

Number of citations of the paper that reports this interaction (PubMedID 21275903)
45

Data Source:
BioGRID (two hybrid)

		WAPL	ARAP1
Description		WAPL cohesin release factor	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Intercellular Bridge Mitotic Spindle	Ruffle Podosome Nucleoplasm Cytoplasm Endosome Early Endosome Multivesicular Body Golgi Apparatus Golgi Stack Trans-Golgi Network Cytosol Plasma Membrane Membrane Extrinsic Component Of Plasma Membrane Cell Projection Anchoring Junction
	Molecular Function	Protein Binding ATP-dependent Protein-DNA Unloader Activity	GTPase Activator Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Zinc Ion Binding Type 1 Angiotensin Receptor Binding Metal Ion Binding
	Biological Process	Mitotic Sister Chromatid Segregation Negative Regulation Of DNA Replication Negative Regulation Of Chromatin Binding Negative Regulation Of Sister Chromatid Cohesion Cell Division Protein Localization To Chromatin	Positive Regulation Of Receptor Recycling Regulation Of Receptor Internalization Actin Filament Organization Signal Transduction Regulation Of Cell Shape Regulation Of Endocytosis Regulation Of Cell Projection Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of GTPase Activity Regulation Of Bone Resorption Photoreceptor Cell Maintenance Positive Regulation Of Phagocytosis Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Cellular Component Organization Positive Regulation Of Filopodium Assembly Negative Regulation Of Stress Fiber Assembly
Pathways		Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion	PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Parental longevity (father's age at death) ( 31484785)	Acute insulin response ( 28490609) Alcohol dependence symptom count ( 29460428) Alloimmunization response to red blood cell transfusion in sickle cell anemia ( 25670933) Body fat percentage and fasting glucose (pairwise) ( 33619380) Body fat percentage and type 2 diabetes (pairwise) ( 33619380) Body mass index ( 25673413 28892062) Body mass index and fasting glucose (pairwise) ( 33619380) Body mass index and type 2 diabetes (pairwise) ( 33619380) Fasting blood glucose ( 22581228 25631608) Fasting blood glucose (BMI interaction) ( 22581228) Fasting blood proinsulin levels ( 23263489) Fasting glucose ( 34059833) Glycated hemoglobin levels ( 28898252) Household income (MTAG) ( 31844048) Insulin-related traits (multivariate analysis) ( 32002517) Mean platelet volume ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Medication use (drugs used in diabetes) ( 31015401) Proinsulin levels ( 21873549) Rheumatoid arthritis ( 22446963) Type 2 diabetes ( 30297969 30718926 30054458 26961502 29358691 32499647 28869590 26818947 24509480 22885922) Waist circumference ( 28552196) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		7 interacting genes: ARAP1 BTG3 CDCA5 MTNR1A RAD21 SUMO2 XRN1	15 interacting genes: APP ARIH2 ARPC3 CDC42 FGFR3 FILNC1 INPP5D KCTD12 PSD3 RAC1 TAB1 TES TP53BP1 WAPL XRCC6
Entrez ID		23063	116985
HPRD ID		11072	09440
Ensembl ID		ENSG00000062650	ENSG00000186635
Uniprot IDs		A8K273 B2RTX8 Q7Z5K2	E7EU13 Q96P48
PDB IDs		4K6J 5HDT	4X1V
Enriched GO Terms of Interacting Partners?		Sister Chromatid Cohesion Negative Regulation Of Chromosome Organization Cellular Response To Puromycin Cellular Response To Cycloheximide	Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Thioesterase Binding G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Focal Adhesion Cellular Response To X-ray Double-strand Break Repair Via Classical Nonhomologous End Joining Positive Regulation Of Immune System Process Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Cell Activation Regulation Of Signal Transduction Regulation Of Supramolecular Fiber Organization Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Postsynapse Organization Positive Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Regulation Of Endocytosis Positive Regulation Of Lamellipodium Assembly GTP-dependent Protein Binding Phagocytosis, Engulfment Telomeric DNA Binding Hyperosmotic Response Response To X-ray Regulation Of Synaptic Vesicle Endocytosis Regulation Of Synaptic Vesicle Recycling Negative Regulation Of DNA Replication Intracellular Signal Transduction Positive Regulation Of Supramolecular Fiber Organization Protein-containing Complex Cell Projection Positive Regulation Of Lamellipodium Organization Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Innate Immune Response Regulation Of Lamellipodium Assembly Positive Regulation Of MAPK Cascade Protein Homooligomerization Neuron Projection Organization Intracellular Signaling Cassette Receptor Complex Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Response To Nerve Growth Factor Amylin Binding Positive Regulation Of Toll Signaling Pathway Dendrite Development Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Regulation Of Signaling
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