WAPAL and ARAP1

Number of citations of the paper that reports this interaction (PMID 21275903)
4

Data Source:
BioGRID (two hybrid)

		WAPAL	ARAP1
Gene Name		wings apart-like homolog (Drosophila)	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Chromosome, Centromeric Region Chromatin Synaptonemal Complex Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Cohesin Complex Microtubule Cytoskeleton Intracellular Membrane-bounded Organelle	Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Cytoplasmic Vesicle Golgi Cisterna Membrane
	Molecular Function	Protein Binding	Rho GTPase Activator Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding ARF GTPase Activator Activity Zinc Ion Binding Type 1 Angiotensin Receptor Binding
	Biological Process	Mitotic Cell Cycle Mitotic Nuclear Division Negative Regulation Of DNA Replication Response To Toxic Substance Viral Process Negative Regulation Of Chromatin Binding Negative Regulation Of Sister Chromatid Cohesion Positive Regulation Of Fibroblast Proliferation Cell Division Regulation Of Chromosome Condensation Protein Localization To Chromatin Regulation Of Cohesin Localization To Chromatin	Positive Regulation Of Receptor Recycling Small GTPase Mediated Signal Transduction Regulation Of Cell Shape Actin Filament Reorganization Involved In Cell Cycle Regulation Of ARF GTPase Activity Positive Regulation Of Cdc42 GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cellular Component Movement Positive Regulation Of Filopodium Assembly Negative Regulation Of Stress Fiber Assembly
Pathways		Establishment of Sister Chromatid Cohesion Mitotic Prometaphase Mitotic Telophase/Cytokinesis Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Mitotic Anaphase S Phase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase	Rho GTPase cycle Signaling by Rho GTPases
Drugs
Diseases
GWAS		Periodontal microbiota ( 22699663)	Fasting glucose-related traits (interaction with BMI) ( 22581228) Proinsulin levels ( 21873549) Rheumatoid arthritis ( 22446963)
Protein-Protein Interactions		4 interactors: ARAP1 PDS5A RAD21 XRN1	13 interactors: APP ARIH2 ARPC3 FGFR3 INPP5D KCTD12 PSD3 SH3KBP1 TAB1 TES TP53BP1 WAPAL XRCC6
Entrez ID		23063	116985
HPRD ID		11072	09440
Ensembl ID		ENSG00000062650	ENSG00000186635
Uniprot IDs		Q7Z5K2	E7EU13 Q96P48
PDB IDs		4K6J
Enriched GO Terms of Interacting Partners?		Actin Filament Reorganization Involved In Cell Cycle Cell Cycle Process Chromosome Segregation Actin Filament Reorganization Cell Cycle Mitotic Nuclear Division Nuclear MRNA Surveillance RNA Surveillance Histone MRNA Catabolic Process Negative Regulation Of Stress Fiber Assembly Cell Division RRNA Catabolic Process Protein Localization To Chromatin Negative Regulation Of Actin Filament Bundle Assembly Mitotic Sister Chromatid Cohesion Positive Regulation Of Receptor Recycling Positive Regulation Of Cdc42 GTPase Activity Histone MRNA Metabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Regulation Of Receptor Recycling Regulation Of Cdc42 GTPase Activity Mitotic Cell Cycle Process Protein Localization To Chromosome Sister Chromatid Cohesion Regulation Of Cdc42 Protein Signal Transduction Mitotic Cell Cycle Positive Regulation Of Filopodium Assembly Reciprocal Meiotic Recombination Negative Regulation Of DNA Replication Regulation Of Filopodium Assembly Organelle Organization Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of Stress Fiber Assembly Actin Cytoskeleton Reorganization Regulation Of ARF GTPase Activity Mitotic Sister Chromatid Segregation	Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Innate Immune Response Immune System Process Immune Response-regulating Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Signal Transduction Fc Receptor Signaling Pathway Developmental Growth Defense Response Regulation Of Signaling Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Regulation Of Immune Response Generation Of Neurons Response To Stress Developmental Cell Growth Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Sister Chromatid Cohesion Synaptic Growth At Neuromuscular Junction Multicellular Organismal Development Neurogenesis Apoptotic Process Regulation Of Chromosome Condensation Cellular Hyperosmotic Salinity Response Collateral Sprouting In Absence Of Injury Programmed Cell Death Regulation Of Cellular Process Cell Death Death Regulation Of Cell Cycle Process Growth Regulation Of Cohesin Localization To Chromatin Neuron Differentiation Axonogenesis Collateral Sprouting Axon Midline Choice Point Recognition Developmental Growth Involved In Morphogenesis Double-strand Break Repair Cell Growth System Development Developmental Process Alveolar Secondary Septum Development Negative Regulation Of Interleukin-6 Biosynthetic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Cellular Response To X-ray Axon Development Epidermal Growth Factor Receptor Signaling Pathway Cell Morphogenesis Involved In Neuron Differentiation
Tagcloud ?			abl1 annotates bcr casl centd2 compensate crk crki crkii directionality dok dok1 dok2 gab2 gtpase gtpases hef1 layered lrrk1 lrrk2 modular nedd9 paralog pleiotropic pragmin rhoa sgk223 shc1 wise
Tagcloud (Difference) ?			abl1 annotates bcr casl centd2 compensate crk crki crkii directionality dok dok1 dok2 gab2 gtpase gtpases hef1 layered lrrk1 lrrk2 modular nedd9 paralog pleiotropic pragmin rhoa sgk223 shc1 wise
Tagcloud (Intersection) ?