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WAPL

Description WAPL cohesin release factor
Image
GO Annotations Cellular Component
  • Chromosome, Centromeric Region
  • Chromatin
  • Nucleus
  • Nucleoplasm
  • Chromosome
  • Cytoplasm
  • Cytosol
  • Intercellular Bridge
  • Mitotic Spindle
Molecular Function
  • Protein Binding
  • ATP-dependent Protein-DNA Unloader Activity
Biological Process
  • Mitotic Sister Chromatid Segregation
  • Negative Regulation Of DNA Replication
  • Negative Regulation Of Chromatin Binding
  • Negative Regulation Of Sister Chromatid Cohesion
  • Cell Division
  • Protein Localization To Chromatin
Pathways
  • Separation of Sister Chromatids
  • Establishment of Sister Chromatid Cohesion
  • Cohesin Loading onto Chromatin
  • Resolution of Sister Chromatid Cohesion
Drugs
Diseases
GWAS
  • Parental longevity (father's age at death) ( 31484785)
Interacting Genes 7 interacting genes: ARAP1 BTG3 CDCA5 MTNR1A RAD21 SUMO2 XRN1
Entrez ID 23063
HPRD ID 11072
Ensembl ID ENSG00000062650
Uniprot IDs A8K273 B2RTX8 Q7Z5K2
PDB IDs 4K6J 5HDT
Enriched GO Terms of Interacting Partners?
  • Sister Chromatid Cohesion
  • Negative Regulation Of Chromosome Organization
  • Cellular Response To Puromycin
  • Cellular Response To Cycloheximide
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