WAPAL and RAD21

Number of citations of the paper that reports this interaction (PMID 17112726)
82

Data Source:
HPRD (in vivo)

		WAPAL	RAD21
Gene Name		wings apart-like homolog (Drosophila)	RAD21 homolog (S. pombe)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Chromosome, Centromeric Region Chromatin Synaptonemal Complex Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Cohesin Complex Microtubule Cytoskeleton Intracellular Membrane-bounded Organelle	Chromosome, Centromeric Region Chromatin Nucleoplasm Chromosome Cytosol Cohesin Complex Membrane Nuclear Meiotic Cohesin Complex
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Mitotic Cell Cycle Mitotic Nuclear Division Negative Regulation Of DNA Replication Response To Toxic Substance Viral Process Negative Regulation Of Chromatin Binding Negative Regulation Of Sister Chromatid Cohesion Positive Regulation Of Fibroblast Proliferation Cell Division Regulation Of Chromosome Condensation Protein Localization To Chromatin Regulation Of Cohesin Localization To Chromatin	Mitotic Cell Cycle Double-strand Break Repair DNA Recombination Regulation Of Transcription From RNA Polymerase II Promoter Apoptotic Process Chromosome Segregation Mitotic Nuclear Division Reciprocal Meiotic Recombination Cell Division Protein Localization To Chromatin
Pathways		Establishment of Sister Chromatid Cohesion Mitotic Prometaphase Mitotic Telophase/Cytokinesis Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Mitotic Anaphase S Phase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase	Establishment of Sister Chromatid Cohesion Mitotic Prometaphase Mitotic Telophase/Cytokinesis Separation of Sister Chromatids Meiotic synapsis Cohesin Loading onto Chromatin Mitotic Anaphase S Phase M Phase Cell Cycle, Mitotic Resolution of Sister Chromatid Cohesion Mitotic Metaphase and Anaphase
Drugs
Diseases
GWAS		Periodontal microbiota ( 22699663)
Protein-Protein Interactions		4 interactors: ARAP1 PDS5A RAD21 XRN1	28 interactors: CAPN1 CASP7 CFL1 COX2 CSTB DISC1 DYNLT1 FHL3 FLNB HNRNPH2 IL7R MSRB2 NUMA1 PPP1R15A PPP1R15B RPL10 RPL13 RPL35A SMARCA5 SMC1A SSU72 STAG1 STAG2 TMSB4X TNFRSF14 WAPAL WNT2B ZNF80
Entrez ID		23063	5885
HPRD ID		11072	05924
Ensembl ID		ENSG00000062650	ENSG00000164754
Uniprot IDs		Q7Z5K2	O60216
PDB IDs		4K6J
Enriched GO Terms of Interacting Partners?		Actin Filament Reorganization Involved In Cell Cycle Cell Cycle Process Chromosome Segregation Actin Filament Reorganization Cell Cycle Mitotic Nuclear Division Nuclear MRNA Surveillance RNA Surveillance Histone MRNA Catabolic Process Negative Regulation Of Stress Fiber Assembly Cell Division RRNA Catabolic Process Protein Localization To Chromatin Negative Regulation Of Actin Filament Bundle Assembly Mitotic Sister Chromatid Cohesion Positive Regulation Of Receptor Recycling Positive Regulation Of Cdc42 GTPase Activity Histone MRNA Metabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Regulation Of Receptor Recycling Regulation Of Cdc42 GTPase Activity Mitotic Cell Cycle Process Protein Localization To Chromosome Sister Chromatid Cohesion Regulation Of Cdc42 Protein Signal Transduction Mitotic Cell Cycle Positive Regulation Of Filopodium Assembly Reciprocal Meiotic Recombination Negative Regulation Of DNA Replication Regulation Of Filopodium Assembly Organelle Organization Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of Stress Fiber Assembly Actin Cytoskeleton Reorganization Regulation Of ARF GTPase Activity Mitotic Sister Chromatid Segregation	Cell Division Mitotic Nuclear Division Cellular Protein Localization Viral Life Cycle Cytoskeleton Organization Mitotic Cell Cycle Process Negative Regulation Of DNA Endoreduplication Protein Localization To Endoplasmic Reticulum Cell Cycle Process Mitotic Cell Cycle Organelle Organization Protein Localization To Organelle Negative Regulation Of DNA Replication MRNA Metabolic Process Viral Process Protein Localization Cellular Localization Cellular Protein Complex Disassembly Regulation Of DNA Endoreduplication Protein Complex Disassembly Cell Cycle Negative Regulation Of Cell Cycle Viral Transcription Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay SRP-dependent Cotranslational Protein Targeting To Membrane Establishment Of Cell Polarity Negative Regulation Of DNA Metabolic Process Cotranslational Protein Targeting To Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Regulation Of DNA Replication Sister Chromatid Cohesion Establishment Of Mitotic Spindle Orientation Actin Cytoskeleton Organization Translational Termination Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Establishment Of Protein Localization To Organelle Nuclear-transcribed MRNA Catabolic Process Actin Filament-based Process MRNA Catabolic Process Protein Targeting To Membrane Establishment Or Maintenance Of Cell Polarity Viral Entry Into Host Cell Translational Elongation Spindle Localization Regulation Of Metabolic Process Entry Into Host Cell RNA Catabolic Process Positive Regulation Of Translational Initiation In Response To Stress
Tagcloud ?			aberrations apart aspect ccnd1 clinicopathological copy covered encompassed endometrial erbb1 erbb2 erbb3 erbb4 esr1 frequent infiltration insufficient myometrial pakt1 pgr pik3ca prom1 rad27 runx1 scgb2a2 snai1 snai2 top2a younger
Tagcloud (Difference) ?			aberrations apart aspect ccnd1 clinicopathological copy covered encompassed endometrial erbb1 erbb2 erbb3 erbb4 esr1 frequent infiltration insufficient myometrial pakt1 pgr pik3ca prom1 rad27 runx1 scgb2a2 snai1 snai2 top2a younger
Tagcloud (Intersection) ?