KDM1A and USP28

Number of citations of the paper that reports this interaction (PMID 24075993)
1

Data Source:
BioGRID (enzymatic study)

		KDM1A	USP28
Gene Name		lysine (K)-specific demethylase 1A	ubiquitin specific peptidase 28
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Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex	Nucleus Nucleoplasm Nucleolus Protein Complex
	Molecular Function	RNA Polymerase II Transcription Factor Binding P53 Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Oxidoreductase Activity Enzyme Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Demethylase Activity Histone Demethylase Activity Histone Demethylase Activity (H3-K4 Specific) Histone Demethylase Activity (H3-K9 Specific) Histone Demethylase Activity (H3-dimethyl-K4 Specific) MRF Binding Transcription Regulatory Region DNA Binding Flavin Adenine Dinucleotide Binding Androgen Receptor Binding	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development Chromatin Organization Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Protein Demethylation Blood Coagulation Cell Proliferation Regulation Of Primitive Erythrocyte Differentiation Pituitary Gland Development Granulocyte Differentiation Negative Regulation Of Protein Binding Histone H3-K9 Demethylation Histone H3-K4 Demethylation Negative Regulation Of DNA Binding Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Megakaryocyte Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Hormone Biosynthetic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Histone H3-K4 Methylation Negative Regulation Of Histone H3-K9 Methylation Muscle Cell Development Oxidation-reduction Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Stem Cell Proliferation	DNA Damage Checkpoint DNA Repair Cellular Response To DNA Damage Stimulus Cell Proliferation Response To Ionizing Radiation Protein Deubiquitination Cellular Response To UV Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process
Pathways		Chromatin modifying enzymes HDACs deacetylate histones Chromatin organization HDMs demethylate histones Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS
Protein-Protein Interactions		219 interactors: AKAP9 ANKEF1 AP1G2 AR ARHGAP15 ARHGAP29 ASB10 ASB3 ASCC2 ATP5J2 ATP6V1B1 BAHD1 BAIAP2 BATF BCAT1 BLZF1 BMP3 BRCA1 C16orf59 C17orf82 C18orf54 C4orf17 C8orf48 C8orf74 CCDC121 CCDC14 CCDC151 CCDC155 CCDC172 CCDC37 CCDC53 CCDC74A CCDC74B CCDC90B CDC23 CDC5L CDCA4 CDCA5 CENPQ CEP162 CEP70 CRBN CRLF3 CTBP1 DBF4B DNAJA3 DNTTIP1 DYX1C1 E2F1 ECI2 ELOF1 EXOC1 EZH2 FAM9A FIGNL1 FYCO1 FYN GABPB2 GDF9 GLYR1 GOLGA2 GPATCH2L GSTCD GTPBP2 H3F3C HAUS1 HAUS3 HAUS6 HDAC1 HESX1 HIST1H3A HIST2H3C HIST3H3 HOXA1 ID2 IFI35 IGFBP4 IK IKBIP IL16 IMMT INTS2 ISL1 ITGB3BP ITSN2 KANSL1 KDM5B KIAA0408 KIFC3 KLC3 KLF3 KLHDC4 KRT17 KRT19 KRT222 KRT33B KRT38 KRT6A KRT6B KRT7 L3MBTL3 LENG8 LOXL4 MALT1 MBD3 MBD4 MCPH1 MCRS1 MLC1 MNS1 MTA3 MTF2 MTMR9 MTO1 MYC MYLIP NBPF15 NDUFA8 NDUFS1 NECAB2 NEFL NF2 NMI NOSTRIN NR1H2 NR1H3 NR2C2 NR2E1 OFCC1 OIP5 OPA3 OTUB1 PDCD5 PDE4DIP PEX7 PHC2 PHF19 PHF20L1 PHF21A PMF1 PNKP PPARD PPP1R12A PRDM1 PRIM2 PSMC1 PSMC3 RASSF1 RASSF2 RASSF8 RCOR1 RCOR3 RNF10 RPRD1A SAMD3 SEPT6 SERGEF SETDB1 SF3B2 SH3GLB2 SLU7 SMAD9 SMARCD1 SMN1 SNF8 SNX15 SOCS6 SPATA22 SPATA24 SPICE1 SPRY2 SPSB1 SPZ1 SRGAP3 SSX2IP STAT3 STX11 STX19 SUMO1 SUMO2 SUV39H1 TACC1 TADA3 TAL1 TDO2 TERF1 TEX35 TEX9 TNFAIP1 TNNT2 TP53 TRAF4 TRIM39 TRIM54 TSACC TSC1 TTC33 UBA3 UCHL5 UNC119 UNKL USP28 VPS11 VPS37A WBSCR27 WDR83 YEATS4 ZBTB24 ZCCHC17 ZFP28 ZNF280A ZNF333 ZNF436 ZNF451 ZNF480 ZNF581 ZNF641 ZNF71 ZNF829	33 interactors: ATXN3L BAP1 CLSPN ESPL1 JOSD1 KDM1A MDC1 NSMCE2 OTUB1 OTUB2 PJA1 PLA2G2A RFFL SENP8 STAM STAMBP TP53BP1 TRIM55 TRIM63 UBC UCHL1 UCHL3 UCHL5 USP14 USP15 USP20 USP21 USP33 USP4 USP5 USP51 USP7 USP8
Entrez ID		23028	57646
HPRD ID		09800	15632
Ensembl ID		ENSG00000004487	ENSG00000048028
Uniprot IDs		O60341	B4E3L3 Q96RU2
PDB IDs		2COM 2DW4 2EJR 2H94 2HKO 2IW5 2L3D 2UXN 2UXX 2V1D 2X0L 2XAF 2XAG 2XAH 2XAJ 2XAQ 2XAS 2Y48 2Z3Y 2Z5U 3ABT 3ABU 3ZMS 3ZMT 3ZMU 3ZMV 3ZMZ 3ZN0 3ZN1	2LVA
Enriched GO Terms of Interacting Partners?		Cell Cycle Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Organelle Organization Gene Expression RNA Metabolic Process Mitotic Cell Cycle Cell Cycle Process Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Mitotic Cell Cycle Process Chromosome Organization Negative Regulation Of Biosynthetic Process Chromatin Organization Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Chromatin Modification Regulation Of Transcription From RNA Polymerase II Promoter Cellular Process Negative Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Metabolic Process Regulation Of Chromosome Organization Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Regulation Of Cellular Component Organization Biosynthetic Process Regulation Of Cellular Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Developmental Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Protein Modification By Small Protein Conjugation	Protein Modification By Small Protein Removal Protein Deubiquitination Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Deubiquitination Proteasomal Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Cellular Macromolecule Catabolic Process Regulation Of Protein Catabolic Process Cellular Protein Modification Process Regulation Of Proteolysis Catabolic Process Cellular Protein Metabolic Process Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Protein K63-linked Deubiquitination Histone Deubiquitination Cellular Metabolic Process Monoubiquitinated Protein Deubiquitination Histone Modification DNA Repair Metabolic Process Mitotic Cell Cycle Regulation Of Metabolic Process Chromosome Organization Negative Regulation Of Cellular Protein Metabolic Process Cellular Response To DNA Damage Stimulus Chromatin Modification Negative Regulation Of Protein Metabolic Process Cellular Response To Stress Mitotic Cell Cycle Process Regulation Of Cellular Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Chromatin Organization Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Cellular Protein Catabolic Process Cell Cycle Cell Cycle Process DNA Metabolic Process Negative Regulation Of Signal Transduction Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Proteasomal Protein Catabolic Process
Tagcloud ?		aml blasts ccaat confers corepressor corest demethylase demethylates depleted di engrafted engraftment exhibiting h3k4me3 hdi lsd1 mark me2 mono npm1 oncoproteins pan panobinostat permissive ps shrna sp2509 synergistically warranting	acetylcysteine antioxidants brief cyld cylindromatosis deprivation diminished dram generating glutaredoxin glutathione glycolysis grx2a hepg2 homolog isoform mediation menadione modulator peptidase peroxide pten ros state steady superoxide tensin tigar transfectants
Tagcloud (Difference) ?		aml blasts ccaat confers corepressor corest demethylase demethylates depleted di engrafted engraftment exhibiting h3k4me3 hdi lsd1 mark me2 mono npm1 oncoproteins pan panobinostat permissive ps shrna sp2509 synergistically warranting	acetylcysteine antioxidants brief cyld cylindromatosis deprivation diminished dram generating glutaredoxin glutathione glycolysis grx2a hepg2 homolog isoform mediation menadione modulator peptidase peroxide pten ros state steady superoxide tensin tigar transfectants
Tagcloud (Intersection) ?