KDM1A and TSC1

Number of citations of the paper that reports this interaction (PubMedID 23455924)
0

Data Source:
BioGRID (two hybrid)

		KDM1A	TSC1
Description		lysine demethylase 1A	TSC complex subunit 1
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Chromosome Protein-containing Complex Histone Methyltransferase Complex DNA Repair Complex	Nucleus Cytoplasm Lysosome Lysosomal Membrane Lipid Droplet Cytosol Actin Filament Plasma Membrane Cell Cortex Postsynaptic Density Membrane Lamellipodium Protein-containing Complex TSC1-TSC2 Complex Ciliary Basal Body Perinuclear Region Of Cytoplasm Protein Folding Chaperone Complex
	Molecular Function	P53 Binding Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity RNA Binding Protein Binding Oxidoreductase Activity Enzyme Binding Histone Demethylase Activity Histone H3K4 Demethylase Activity Histone H3K9 Demethylase Activity Telomeric DNA Binding Identical Protein Binding MRF Binding Flavin Adenine Dinucleotide Binding Nuclear Androgen Receptor Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Telomeric Repeat-containing RNA Binding DNA-binding Transcription Factor Binding Protein Demethylase Activity FAD-dependent H3K4me/H3K4me3 Demethylase Activity Promoter-specific Chromatin Binding	Protein Binding Hsp70 Protein Binding ATPase Inhibitor Activity Protein Folding Chaperone Protein-folding Chaperone Binding Hsp90 Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Epithelial To Mesenchymal Transition Positive Regulation Of Neuroblast Proliferation Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Neuron Projection Development Cerebral Cortex Development Positive Regulation Of Protein Ubiquitination Regulation Of Protein Localization Cellular Response To UV Protein Modification Process Epigenetic Regulation Of Gene Expression Neuron Maturation Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Cell Differentiation Positive Regulation Of Cell Size Positive Regulation Of Transcription By RNA Polymerase II Guanine Metabolic Process Regulation Of Neurogenesis Positive Regulation Of Multicellular Organismal Process Muscle Cell Development Regulation Of Androgen Receptor Signaling Pathway Response To Fungicide Cellular Response To CAMP Cellular Response To Gamma Radiation Positive Regulation Of Cold-induced Thermogenesis DNA Repair-dependent Chromatin Remodeling Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Stem Cell Proliferation	Kidney Development Neural Tube Closure Regulation Of Cell-matrix Adhesion Adaptive Immune Response Protein Folding Potassium Ion Transport Cell-matrix Adhesion Nervous System Development Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Associative Learning Adult Locomotory Behavior Cellular Response To Starvation Negative Regulation Of Macroautophagy Hippocampus Development Cerebral Cortex Development Cell Projection Organization Negative Regulation Of TOR Signaling Negative Regulation Of ATP-dependent Activity Response To Insulin Cellular Response To Decreased Oxygen Levels TORC1 Signaling Myelination Memory T Cell Differentiation Negative Regulation Of Cell Size D-glucose Import Synapse Organization Protein Stabilization Regulation Of Stress Fiber Assembly Regulation Of Cell Cycle Positive Regulation Of Focal Adhesion Assembly Cardiac Muscle Cell Differentiation Activation Of GTPase Activity Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling
Pathways		HDACs deacetylate histones HDMs demethylate histones Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Regulation of PTEN gene transcription Estrogen-dependent gene expression NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Potential therapeutics for SARS Negative Regulation of CDH1 Gene Transcription Factors involved in megakaryocyte development and platelet production	Macroautophagy Inhibition of TSC complex formation by PKB Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes TBC/RABGAPs
Drugs		Vafidemstat
Diseases			Lymphangioleiomyomatosis (LAM) Tuberous sclerosis complex (TSC); Bourneville-Pringle disease
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Gamma glutamyl transferase levels ( 29403010 33339817) Global electrical heterogeneity phenotypes ( 29622589) Pulse pressure ( 27841878) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Migraine without aura ( 23793025) Psoriasis ( 19169254)
Interacting Genes		262 interacting genes: ACE2 AKAP9 ANKEF1 ANKRD23 AP1G2 AR ARHGAP15 ARHGAP29 ASB10 ASB3 ASCC2 ATP5MF ATP6V1B1 BAHD1 BAIAP2 BATF BCAT1 BIRC2 BLZF1 BMP3 BRCA1 C18orf54 C4orf17 C8orf48 C8orf74 CAGE1 CARD10 CARM1 CCDC121 CCDC14 CCDC172 CCDC33 CCDC74A CCDC74B CCDC90B CDCA4 CDCA5 CENPQ CEP162 CEP57 CEP70 CEP76 CFAP100 COIL CRBN CRLF3 CSNK2A1 CSNK2A2 DBF4B DNAAF4 DNAJA3 DNTTIP1 DRC4 E2F1 ECI2 ELOF1 EXOC1 EXOC7 FAM161A FAM204A FAM9A FBXO24 FIGNL1 FYCO1 FYN GABPB2 GATA3 GCC1 GDF9 GLYR1 GOLGA2 GOLGA6A GPATCH2L GSK3B GSTCD GTPBP2 H3-4 H3-5 H3C1 H3C14 HAUS1 HAUS3 HAUS6 HDAC1 HESX1 HOMER3 HOXA1 ID2 IFI35 IGFBP4 IK IKBIP IL16 IMMT INSM1 INTS2 ISL1 ITGB3BP ITSN2 JRK KANSL1 KASH5 KDM5B KIAA0408 KIFC3 KLC3 KLHDC4 KRT15 KRT17 KRT19 KRT222 KRT31 KRT33B KRT35 KRT38 KRT39 KRT40 KRT6A KRT6B KRT7 L3MBTL3 LENG8 LINC00511 LINC02875 LOXL4 LZTS1 MALT1 MBD3 MBD4 MCPH1 MCRS1 METTL27 MLC1 MNS1 MTA3 MTF2 MTMR9 MTO1 MYC MYLIP NBPF15 NBPF26 NDUFA8 NDUFS1 NECAB2 NEFL NFE2L2 NMI NOSTRIN NR1H2 NR1H3 NR2C2 NR2E1 NRBF2 ODAD3 OFCC1 OIP5 OPA3 OTUB1 PBX4 PDCD5 PDE4DIP PEX7 PFDN5 PHC2 PHF19 PHF20L1 PHF21A PMF1 PNKP PPARD PPM1D PPP1R12A PRDM1 PRIM2 PSMC1 PSMC3 PTEN RASSF1 RASSF2 RASSF3 RASSF8 RCOR1 RCOR3 RIOK1 RNF10 RNF168 RPRD1A SAMD3 SEPTIN6 SERGEF SETDB1 SF3B2 SH3GLB2 SLU7 SMAD9 SMARCD1 SMN1 SNF8 SNX15 SOCS6 SPATA22 SPATA24 SPICE1 SPRY2 SPSB1 SPZ1 SRGAP3 SSX2IP STAT3 STX11 STX19 SUMO2 SUV39H1 TACC1 TADA3 TAL1 TDO2 TEDC2 TERF1 TEX35 TEX9 TFIP11 TLE5 TNFAIP1 TNNT2 TP53 TP53BP1 TRAF4 TRIM39 TRIM54 TSACC TSC1 TTC23 TTC33 UBA3 UBASH3B UBE2I UCHL5 UNC119 UNKL USP28 VPS11 VPS37A VPS37B WASHC3 WDR83 ZBED1 ZBTB24 ZBTB39 ZCCHC17 ZFP28 ZNF280A ZNF333 ZNF436 ZNF451 ZNF480 ZNF581 ZNF641 ZNF71 ZNF750 ZNF829	169 interacting genes: ABI1 ACTN1 ACTN2 AKT1 ANKIB1 ANKRD24 ANKRD35 APPL2 AQP1 ARAF ARID5A ATN1 ATXN1 AURKA AXIN1 BAG3 BCL11A BECN1 BEND5 C1orf94 CALCOCO2 CASC3 CCDC120 CCDC88B CCL28 CCNB1 CCND2 CCNE1 CDK1 CDK4 CDK6 CDKN2A CDKN2B CDR2 CHCHD2 CNIH1 CNTRL CNTROB COG6 CSTF2 CTNNB1 DACH2 DCTN2 DMRT3 DOK5 EIF3A ENKD1 EZR FAM110A FAM222B FBF1 FGFR4 FOXH1 FRS3 GCC1 GEMIN8 GFAP GLIS2 GOLGA2 GPANK1 GPATCH1 HECW1 HGS HNRNPM HOMER3 HOOK2 HOXC8 HR HSH2D ICA1 IGFN1 IKBKB KANSL2 KAT2A KAZN KDM1A KIF1C KIF5A KLC1 KLC4 LATS2 LENG1 LMO2 LRSAM1 LUC7L LZTS2 MAP2K5 MAPK14 MBIP MBP MSANTD3 MSN MT-ND1 MYC MYLIP MYOZ3 NECAB2 NEFL NF2 NINL NKD2 NRBF2 PATL1 PATZ1 PHLDB1 PICK1 PITX1 PLK1 PLK2 POGZ POU6F2 PPFIA2 PPP1R18 PRMT6 RALYL RASSF1 RBPMS RDX RHEB RIN1 RIN3 RUNDC3A SAMD11 SAMD7 SAXO4 SCMH1 SEC31A SELENOW SERTAD1 SH2D2A SHANK1 SHC3 SMG9 SORBS3 SOX4 SPAG5 SPAG8 SUOX TANK TBC1D7 TBX6 TCF7L2 TFAP2D TFIP11 TLE5 TNS2 TRIM3 TRIOBP TSC2 TSGA10IP TSHZ3 USP2-AS1 VENTX VEZF1 VGLL3 VIM VPS37C YPEL3 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZIC1 ZNF417 ZNF423 ZNF587 ZNF765
Entrez ID		23028	7248
HPRD ID		09800	05594
Ensembl ID		ENSG00000004487	ENSG00000165699
Uniprot IDs		A0A8I5KSH0 A0A8I5KXU4 O60341 R4GMQ1	A0A2R8Y5M3 A0A2R8Y5N2 A0A2R8Y5S3 A0A2R8Y6S1 A0A2R8YD74 A0A2R8YFV7 Q32NF0 Q86WV8 Q92574 X5D9D2
PDB IDs		2COM 2DW4 2EJR 2H94 2HKO 2IW5 2L3D 2UXN 2UXX 2V1D 2X0L 2XAF 2XAG 2XAH 2XAJ 2XAQ 2XAS 2Y48 2Z3Y 2Z5U 3ABT 3ABU 3ZMS 3ZMT 3ZMU 3ZMV 3ZMZ 3ZN0 3ZN1 4BAY 4CZZ 4KUM 4UV8 4UV9 4UVA 4UVB 4UVC 4UXN 4XBF 5AFW 5H6Q 5H6R 5IT3 5L3B 5L3C 5L3D 5L3E 5L3F 5L3G 5LBQ 5LGN 5LGT 5LGU 5LHG 5LHH 5LHI 5X60 5YJB 6E1F 6K3E 6KGK 6KGL 6KGM 6KGN 6KGO 6KGP 6KGQ 6KGR 6NQM 6NQU 6NR5 6S35 6TE1 6TUY 6VYP 6W4K 6WC6 7CDC 7CDD 7CDE 7CDF 7CDG 7E0G 7JJL 7JJM 7JK7 7VQS 7VQT 7VQU 7W3L 7XW8 7ZRY 8BOP 8BOX 8F2Z 8F30 8F59 8F6S 8FDV 8FJ4 8FJ7 8FQJ 8FRI 8FRQ 8FRV 8FSK 8GJ6 8INL 8JF5 8Q1G 8Q1H 8Q1J 8UL6 8UL8 8ULB 8ULC 8UMQ 8UNI 8UOM 8YM7 9DWU 9EL7 9EL8 9ELA 9FWG	4Z6Y 5EJC 7DL2 9C9I 9CE3
Enriched GO Terms of Interacting Partners?		Protein Binding Nucleus Nucleoplasm Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Keratin Filament Regulation Of Nucleobase-containing Compound Metabolic Process Intermediate Filament Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Transcription Cis-regulatory Region Binding Cytoskeleton Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Centrosome Cycle Chromosome Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription DNA Binding Negative Regulation Of RNA Biosynthetic Process Identical Protein Binding Regulation Of Intracellular Estrogen Receptor Signaling Pathway DNA Repair Complex Chromatin Organization Regulation Of Macromolecule Biosynthetic Process Centrosome Negative Regulation Of RNA Metabolic Process Regulation Of Gene Expression Epigenetic Regulation Of Gene Expression Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Chromatin Remodeling Negative Regulation Of Transcription By RNA Polymerase II Nuclear Receptor Activity Cytoplasm Chromatin Binding Cytosol Positive Regulation Of Macromolecule Metabolic Process Organelle Organization Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Zinc Ion Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Cytoskeleton Protein Domain Specific Binding Regulation Of Primary Metabolic Process Cytoplasm Protein Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Protein Localization To Nucleus Positive Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Spindle Pole Microtubule-based Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Microtubule Cytoskeleton Organization Negative Regulation Of Biosynthetic Process Protein Kinase Binding Negative Regulation Of Macromolecule Metabolic Process Identical Protein Binding Cytoskeleton Organization Organelle Organization Negative Regulation Of Metabolic Process G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Intracellular Transport Cell Cycle G1/S Phase Transition Mitotic Cell Cycle Phase Transition Cytoskeletal Protein Binding Cytosol Regulation Of Protein Localization Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Transcription By RNA Polymerase II Microtubule Cytoskeleton Organization Involved In Mitosis MAPK Cascade Cell Cycle Phase Transition Cell Division Positive Regulation Of Early Endosome To Late Endosome Transport Centrosome
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