KDM1A and H3C1

Number of citations of the paper that reports this interaction (PubMedID 31152129)
50

Data Source:
BioGRID (enzymatic study)

		KDM1A	H3C1
Description		lysine demethylase 1A	H3 clustered histone 1
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Chromosome Protein-containing Complex Histone Methyltransferase Complex DNA Repair Complex	Nucleosome Extracellular Region Nucleus Nucleoplasm Chromosome Membrane Protein-containing Complex Extracellular Exosome
	Molecular Function	P53 Binding Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity RNA Binding Protein Binding Oxidoreductase Activity Enzyme Binding Histone Demethylase Activity Histone H3K4 Demethylase Activity Histone H3K9 Demethylase Activity Telomeric DNA Binding Identical Protein Binding MRF Binding Flavin Adenine Dinucleotide Binding Nuclear Androgen Receptor Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Telomeric Repeat-containing RNA Binding DNA-binding Transcription Factor Binding Protein Demethylase Activity FAD-dependent H3K4me/H3K4me3 Demethylase Activity Promoter-specific Chromatin Binding	DNA Binding Protein Binding Structural Constituent Of Chromatin Cadherin Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Epithelial To Mesenchymal Transition Positive Regulation Of Neuroblast Proliferation Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Neuron Projection Development Cerebral Cortex Development Positive Regulation Of Protein Ubiquitination Regulation Of Protein Localization Cellular Response To UV Protein Modification Process Epigenetic Regulation Of Gene Expression Neuron Maturation Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Cell Differentiation Positive Regulation Of Cell Size Positive Regulation Of Transcription By RNA Polymerase II Guanine Metabolic Process Regulation Of Neurogenesis Positive Regulation Of Multicellular Organismal Process Muscle Cell Development Regulation Of Androgen Receptor Signaling Pathway Response To Fungicide Cellular Response To CAMP Cellular Response To Gamma Radiation Positive Regulation Of Cold-induced Thermogenesis DNA Repair-dependent Chromatin Remodeling Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Stem Cell Proliferation	Chromatin Organization Nucleosome Assembly Gene Expression Telomere Organization Epigenetic Regulation Of Gene Expression
Pathways		HDACs deacetylate histones HDMs demethylate histones Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Regulation of PTEN gene transcription Estrogen-dependent gene expression NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Potential therapeutics for SARS Negative Regulation of CDH1 Gene Transcription Factors involved in megakaryocyte development and platelet production	Interleukin-7 signaling Interleukin-7 signaling Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) HDACs deacetylate histones PKMTs methylate histone lysines HDMs demethylate histones HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines Chromatin modifying enzymes SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Assembly of the ORC complex at the origin of replication RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Amyloid fiber formation Chromatin modifications during the maternal to zygotic transition (MZT) Factors involved in megakaryocyte development and platelet production MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription
Drugs		Vafidemstat
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Gamma glutamyl transferase levels ( 29403010 33339817) Global electrical heterogeneity phenotypes ( 29622589) Pulse pressure ( 27841878) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		262 interacting genes: ACE2 AKAP9 ANKEF1 ANKRD23 AP1G2 AR ARHGAP15 ARHGAP29 ASB10 ASB3 ASCC2 ATP5MF ATP6V1B1 BAHD1 BAIAP2 BATF BCAT1 BIRC2 BLZF1 BMP3 BRCA1 C18orf54 C4orf17 C8orf48 C8orf74 CAGE1 CARD10 CARM1 CCDC121 CCDC14 CCDC172 CCDC33 CCDC74A CCDC74B CCDC90B CDCA4 CDCA5 CENPQ CEP162 CEP57 CEP70 CEP76 CFAP100 COIL CRBN CRLF3 CSNK2A1 CSNK2A2 DBF4B DNAAF4 DNAJA3 DNTTIP1 DRC4 E2F1 ECI2 ELOF1 EXOC1 EXOC7 FAM161A FAM204A FAM9A FBXO24 FIGNL1 FYCO1 FYN GABPB2 GATA3 GCC1 GDF9 GLYR1 GOLGA2 GOLGA6A GPATCH2L GSK3B GSTCD GTPBP2 H3-4 H3-5 H3C1 H3C14 HAUS1 HAUS3 HAUS6 HDAC1 HESX1 HOMER3 HOXA1 ID2 IFI35 IGFBP4 IK IKBIP IL16 IMMT INSM1 INTS2 ISL1 ITGB3BP ITSN2 JRK KANSL1 KASH5 KDM5B KIAA0408 KIFC3 KLC3 KLHDC4 KRT15 KRT17 KRT19 KRT222 KRT31 KRT33B KRT35 KRT38 KRT39 KRT40 KRT6A KRT6B KRT7 L3MBTL3 LENG8 LINC00511 LINC02875 LOXL4 LZTS1 MALT1 MBD3 MBD4 MCPH1 MCRS1 METTL27 MLC1 MNS1 MTA3 MTF2 MTMR9 MTO1 MYC MYLIP NBPF15 NBPF26 NDUFA8 NDUFS1 NECAB2 NEFL NFE2L2 NMI NOSTRIN NR1H2 NR1H3 NR2C2 NR2E1 NRBF2 ODAD3 OFCC1 OIP5 OPA3 OTUB1 PBX4 PDCD5 PDE4DIP PEX7 PFDN5 PHC2 PHF19 PHF20L1 PHF21A PMF1 PNKP PPARD PPM1D PPP1R12A PRDM1 PRIM2 PSMC1 PSMC3 PTEN RASSF1 RASSF2 RASSF3 RASSF8 RCOR1 RCOR3 RIOK1 RNF10 RNF168 RPRD1A SAMD3 SEPTIN6 SERGEF SETDB1 SF3B2 SH3GLB2 SLU7 SMAD9 SMARCD1 SMN1 SNF8 SNX15 SOCS6 SPATA22 SPATA24 SPICE1 SPRY2 SPSB1 SPZ1 SRGAP3 SSX2IP STAT3 STX11 STX19 SUMO2 SUV39H1 TACC1 TADA3 TAL1 TDO2 TEDC2 TERF1 TEX35 TEX9 TFIP11 TLE5 TNFAIP1 TNNT2 TP53 TP53BP1 TRAF4 TRIM39 TRIM54 TSACC TSC1 TTC23 TTC33 UBA3 UBASH3B UBE2I UCHL5 UNC119 UNKL USP28 VPS11 VPS37A VPS37B WASHC3 WDR83 ZBED1 ZBTB24 ZBTB39 ZCCHC17 ZFP28 ZNF280A ZNF333 ZNF436 ZNF451 ZNF480 ZNF581 ZNF641 ZNF71 ZNF750 ZNF829	176 interacting genes: AIRE AKT2 ANAPC11 ANP32A ANP32B ASH1L ASH2L ATXN1 AURKA AURKB AURKC BARD1 BCAS3 BRCA1 CARM1 CBX1 CBX2 CBX3 CBX4 CBX5 CBX6 CBX7 CBX8 CDC20 CDYL CDYL2 CENPM CENPT CENPW CHD4 CHUK COPS2 CREBBP CTCFL CUL4A DCAF1 DDB1 DIDO1 DNMT3B DPF2 DTX2 DYRK1A EED EHMT1 EHMT2 EID1 EP300 ERCC6 ESCO1 EZH2 FANCD2 FBLIM1 GATAD2A GATAD2B GLYR1 GRIP1 H1-2 H4C14 HASPIN HAT1 HDAC1 HDAC2 HDAC3 HDAC5 HDAC8 HDGFL3 HNF1B HNRNPA1 HNRNPAB HPF1 HSPA8 ING4 JMJD6 KAT14 KAT2A KAT2B KAT5 KAT6A KAT6B KAT7 KAT8 KDM1A KDM2B KDM4A KDM4C KDM5A KDM6A KDM6B KDM8 KMT2A KMT2B KMT2C KMT2D L3MBTL2 L3MBTL3 MAD2L1 MBD5 MLLT3 MORF4L1 MPHOSPH8 MSL3 MYB NCOR1 NR1H4 NR3C1 NSD1 NSD2 NSD3 PAF1 PAK1 PALB2 PARP10 PARP2 PAXIP1 PBRM1 PHF1 PHF19 PHF20 PHF8 PIAS1 PIKFYVE PPM1D PPP1CA PPP1CB PRDM2 PRKCA PRKCB PRMT1 PRMT7 PWWP3B RAD51B RAG1 RBBP4 RBBP7 RCC1 RNF138 RPS6KA3 SETD1A SETD1B SETD2 SETD7 SETDB1 SF3B1 SHPRH SIRT1 SIRT2 SIRT3 SIRT6 SIRT7 SMARCA2 SMARCA5 SMYD5 SUPT16H SUV39H1 SUV39H2 TAF15 TAF1A TAF1B TAF3 THAP7 TLE3 TMEM132D TRIM24 TRIM33 TSPYL2 TSPYL5 TSSK6 UBR7 UHRF1 UHRF2 USP7 WDR5 WWC1 YEATS4 YWHAB YWHAG
Entrez ID		23028	8350
HPRD ID		09800	04155
Ensembl ID		ENSG00000004487	ENSG00000275714
Uniprot IDs		A0A8I5KSH0 A0A8I5KXU4 O60341 R4GMQ1	P68431
PDB IDs		2COM 2DW4 2EJR 2H94 2HKO 2IW5 2L3D 2UXN 2UXX 2V1D 2X0L 2XAF 2XAG 2XAH 2XAJ 2XAQ 2XAS 2Y48 2Z3Y 2Z5U 3ABT 3ABU 3ZMS 3ZMT 3ZMU 3ZMV 3ZMZ 3ZN0 3ZN1 4BAY 4CZZ 4KUM 4UV8 4UV9 4UVA 4UVB 4UVC 4UXN 4XBF 5AFW 5H6Q 5H6R 5IT3 5L3B 5L3C 5L3D 5L3E 5L3F 5L3G 5LBQ 5LGN 5LGT 5LGU 5LHG 5LHH 5LHI 5X60 5YJB 6E1F 6K3E 6KGK 6KGL 6KGM 6KGN 6KGO 6KGP 6KGQ 6KGR 6NQM 6NQU 6NR5 6S35 6TE1 6TUY 6VYP 6W4K 6WC6 7CDC 7CDD 7CDE 7CDF 7CDG 7E0G 7JJL 7JJM 7JK7 7VQS 7VQT 7VQU 7W3L 7XW8 7ZRY 8BOP 8BOX 8F2Z 8F30 8F59 8F6S 8FDV 8FJ4 8FJ7 8FQJ 8FRI 8FRQ 8FRV 8FSK 8GJ6 8INL 8JF5 8Q1G 8Q1H 8Q1J 8UL6 8UL8 8ULB 8ULC 8UMQ 8UNI 8UOM 8YM7 9DWU 9EL7 9EL8 9ELA 9FWG	1CS9 1CT6 1O9S 1Q3L 2B2T 2B2U 2B2V 2B2W 2C1J 2C1N 2CO0 2CV5 2FSA 2KWJ 2KWK 2L75 2LBM 2LGG 2M0O 2NDF 2NDG 2OQ6 2OT7 2OX0 2RI7 2RR4 2UXN 2V85 2V89 2VNF 2VPG 2X0L 3A1B 3AFA 3AVR 3AYW 3AZE 3AZF 3AZG 3AZH 3AZI 3AZJ 3AZK 3AZL 3AZM 3AZN 3B95 3FDT 3KMT 3KQI 3LQI 3LQJ 3MP1 3O34 3O35 3O37 3QJ6 3RIG 3RIY 3SOU 3SOW 3U31 3U3D 3U4S 3U5N 3U5O 3U5P 3UEE 3UEF 3UIG 3UII 3UIK 3V43 3W96 3W97 3W98 3W99 3WA9 3WAA 3WKJ 3X1S 3X1T 3X1U 3X1V 3ZG6 3ZVY 4A0J 4A0N 4A7J 4BD3 4C1Q 4F4U 4F56 4FWF 4HON 4I51 4L7X 4LK9 4LKA 4LLB 4LXL 4N4H 4QBQ 4QBR 4QBS 4TN7 4U68 4UP0 4UY4 4X3K 4Y6L 4YHP 4YHZ 4YM5 4YM6 4Z0R 4Z2M 5AV5 5AV6 5AV8 5AV9 5AVB 5AVC 5B24 5B2I 5B2J 5B31 5C11 5C13 5C3I 5CPI 5CPJ 5CPK 5D6Y 5DAH 5FB0 5FB1 5FFV 5GH9 5GSE 5GSU 5GT0 5GT3 5GTC 5H6Q 5H6R 5HJB 5HJC 5HJD 5HYN 5IQL 5J3V 5J9S 5JHN 5JIN 5JIY 5JJ0 5JRG 5KJH 5KJI 5KKL 5LUG 5M5G 5MR8 5NNC 5NND 5OY3 5SVX 5SVY 5SZB 5SZC 5T0K 5T0M 5T1G 5T1I 5T8R 5TBN 5TDR 5TDW 5U2J 5V21 5V22 5VA6 5VAB 5VGE 5VNB 5WFC 5WLE 5WVO 5WXG 5WXH 5WYI 5X60 5XF3 5XF4 5XF5 5XFQ 5XFR 5XNV 5XTZ 5Y0C 5Y0D 5Y20 5Y2F 5Z23 5Z30 6AXJ 6AZE 6BHD 6BHE 6BHG 6BHH 6BHI 6D07 6D08 6E83 6E86 6F6D 6HKT 6HTS 6IEU 6IIS 6IIT 6IPU 6IQ4 6JOU 6JR0 6JR1 6JXD 6K1I 6K1J 6K1K 6KE9 6KVD 6L49 6L4A 6L9H 6L9Z 6LA2 6LA8 6LA9 6LAB 6LE9 6LER 6LS6 6LSD 6M3V 6M44 6M4D 6M4G 6M4H 6MIL 6MIM 6MIN 6MIO 6MIQ 6PA1 6PAG 6R8Y 6R8Z 6R90 6R91 6R92 6R93 6R94 6T90 6T93 6UPK 6UPL 6USJ 6V2H 6V2K 6V3N 6V41 6V92 6VIL 6WAV 6WW4 6YIF 6YIH 6YOV 7BWD 7C0M 7CCQ 7CCR 7CFP 7CFQ 7COW 7D1Z 7DBP 7E8D 7EBK 7K5X 7K5Y 7K60 7K61 7K63 7KLR 7LBK 7LBO 7LBP 7LBQ 7LYA 7LYB 7LYC 7MJU 7NL0 7SCY 7SCZ 7TD5 7U0G 7U0I 7U0J 7V6Q 7V90 7V96 7V9C 7V9J 7V9K 7V9S 7VA4 7VZ4 7W9V 7X57 7X58 7XD1 7XVL 7XVM 7XX5 7XX6 7XZX 7XZY 7XZZ 7Y00 7Y5U 7Y5V 7Y5W 7Y60 7Y61 7Y7I 7Y8R 7YOZ 7YQK 7ZI4 8DK5 8DS8 8EVG 8EVH 8EVI 8EVJ 8GE0 8GRM 8GUI 8GUJ 8GUK 8H0V 8H0W 8H1T 8HAG 8HAH 8HAI 8HAJ 8HAK 8HAL 8HAM 8HAN 8HE5 8HLY 8HMX 8I60 8IEG 8IEJ 8IHL 8IIY 8IIZ 8IJ0 8IQF 8IQG 8J6S 8J6T 8JBX 8JCC 8JCD 8JHF 8JHG 8JL9 8JLA 8JND 8JNE 8JNF 8KCY 8KD1 8KE0 8OFF 8OO7 8OOA 8OOP 8OOS 8OSJ 8OSK 8OSL 8OTS 8OTT 8OX0 8OX1 8Q36 8Q3E 8Q3M 8Q3X 8QKT 8RGM 8SMW 8SMX 8SMY 8SMZ 8SN0 8SN1 8SN2 8SN3 8SN4 8SN5 8SN6 8SN7 8SN8 8SN9 8SNA 8SPS 8SPU 8SWI 8SYP 8TXV 8TXW 8TXX 8U13 8U14 8UPF 8VFX 8VFY 8VFZ 8VG0 8VG1 8VG2 8VLR 8VMI 8VML 8VNV 8W9D 8W9E 8W9F 8WG5 8X15 8X19 8X1C 8XBT 8XBU 8XBW 8Y3C 8Y3D 8Y3E 8Y3F 8YBJ 8YBK 8YJF 8YJM 8YNY 8YTI 8YV8 9FGQ 9FH9 9J8M 9J8N 9J8O
Enriched GO Terms of Interacting Partners?		Protein Binding Nucleus Nucleoplasm Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Keratin Filament Regulation Of Nucleobase-containing Compound Metabolic Process Intermediate Filament Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Transcription Cis-regulatory Region Binding Cytoskeleton Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Centrosome Cycle Chromosome Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription DNA Binding Negative Regulation Of RNA Biosynthetic Process Identical Protein Binding Regulation Of Intracellular Estrogen Receptor Signaling Pathway DNA Repair Complex Chromatin Organization Regulation Of Macromolecule Biosynthetic Process Centrosome Negative Regulation Of RNA Metabolic Process Regulation Of Gene Expression Epigenetic Regulation Of Gene Expression Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Chromatin Remodeling Negative Regulation Of Transcription By RNA Polymerase II Nuclear Receptor Activity Cytoplasm Chromatin Binding Cytosol Positive Regulation Of Macromolecule Metabolic Process Organelle Organization Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Zinc Ion Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Chromatin Organization Chromatin Remodeling Nucleoplasm Nucleus Chromatin Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromosome Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Epigenetic Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Heterochromatin Formation Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Histone Binding Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Chromatin Positive Regulation Of Macromolecule Biosynthetic Process Histone Methyltransferase Activity Transferase Activity Protein Modification Process Histone H3 Methyltransferase Activity Zinc Ion Binding Methyltransferase Activity DNA Damage Response Regulation Of DNA Metabolic Process Cellular Response To Stress Methylation Negative Regulation Of Gene Expression Histone Methyltransferase Complex
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?