PALLD and EZR

Number of citations of the paper that reports this interaction (PMID 11598191)
28

Data Source:
HPRD (in vitro, in vivo)

		PALLD	EZR
Gene Name		palladin, cytoskeletal associated protein	ezrin
Image
Gene Ontology Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Mitochondrion Actin Filament Plasma Membrane Focal Adhesion Actin Cytoskeleton Z Disc Lamellipodium	Ruffle Uropod Extracellular Space Nucleolus Cytosol Actin Filament Plasma Membrane Microvillus Focal Adhesion Actin Cytoskeleton Membrane Basolateral Plasma Membrane Apical Plasma Membrane Extrinsic Component Of Membrane Filopodium T-tubule Cortical Cytoskeleton Microvillus Membrane Vesicle Ruffle Membrane Ciliary Basal Body Cell Body Microspike Membrane Raft Apical Part Of Cell Cell Tip Extracellular Vesicular Exosome Cell Periphery Astrocyte Projection Schwann Cell Microvillus
	Molecular Function	Actin Binding Protein Binding Muscle Alpha-actinin Binding	Protein Binding Protein Domain Specific Binding Poly(A) RNA Binding Cell Adhesion Molecule Binding Actin Filament Binding
	Biological Process	Cytoskeleton Organization	Cytoskeletal Anchoring At Plasma Membrane Leukocyte Cell-cell Adhesion Axon Guidance Regulation Of Cell Shape Positive Regulation Of Gene Expression Membrane To Membrane Docking Microvillus Assembly Receptor Internalization Establishment Of Epithelial Cell Apical/basal Polarity Filopodium Assembly Actin Filament Bundle Assembly Establishment Of Endothelial Barrier
Pathways			Axon guidance L1CAM interactions Netrin-1 signaling Recycling pathway of L1
Drugs
Diseases
GWAS		Non-alcoholic fatty liver disease histology (AST) ( 20708005) Response to iloperidone treatment (QT prolongation) ( 18521091)
Protein-Protein Interactions		6 interactors: ACTN1 ACTN2 EZR ITGB5 LIG4 SORBS2	49 interactors: ACTB ACTC1 ADORA2B ADRA1B ARF6 ARHGDIB CD44 CDH1 CDK5 CFTR CLIC5 CTNNB1 DLG1 EGFR FAS FASLG GZMM ICAM1 ICAM2 ICAM3 IQGAP1 L1CAM LCK MDM2 MPP3 MSN NF2 PALLD PIK3R1 PRKAR2A PRKCA PTK2 PTPRC RDX ROCK1 S100P SCYL3 SDC2 SELL SELP SLC9A3R1 SLC9A3R2 SPN TBC1D10A TMEM8B TSC1 VCAM1 WFDC1 WWOX
Entrez ID		23022	7430
HPRD ID		09731	00475
Ensembl ID		ENSG00000129116	ENSG00000092820
Uniprot IDs		B2RTX2 Q8WX93	P15311
PDB IDs		2DM2 2DM3	1NI2
Enriched GO Terms of Interacting Partners?		Cell Adhesion Actin Filament-based Process Actin Filament Organization Actin Filament Bundle Assembly Actin Cytoskeleton Organization Cell-matrix Adhesion Cell-substrate Adhesion Focal Adhesion Assembly Adherens Junction Assembly Cell-substrate Junction Assembly Cytoskeleton Organization Platelet Degranulation Adherens Junction Organization Single Organismal Cell-cell Adhesion Organelle Organization DNA Ligation Involved In DNA Recombination Cell Activation Cellular Component Assembly Protein Localization To Tight Junction Platelet Activation Cell Junction Assembly Cell-cell Junction Organization Membrane To Membrane Docking Muscle Contraction Lagging Strand Elongation Pro-B Cell Differentiation Microspike Assembly Muscle System Process Establishment Of Integrated Proviral Latency Negative Regulation Of Protein Localization To Cell Surface Protein Localization To Cell Junction Cell Projection Assembly Immunoglobulin V(D)J Recombination Establishment Of Viral Latency T Cell Receptor V(D)J Recombination Negative Regulation Of Potassium Ion Transmembrane Transporter Activity DNA Ligation Involved In DNA Repair Leukocyte Cell-cell Adhesion Cytoskeletal Anchoring At Plasma Membrane Exocytosis Lymphoid Progenitor Cell Differentiation Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Potassium Ion Transmembrane Transport DNA Ligation Stress Fiber Assembly Microvillus Assembly Vesicle-mediated Transport Regulation Of Apoptotic Process	Cell Adhesion Single Organismal Cell-cell Adhesion Movement Of Cell Or Subcellular Component Locomotion Cell Migration Regulation Of Immune System Process Regulation Of Cell Adhesion Cell Motility Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Response To Organic Substance Leukocyte Migration Regulation Of Signaling Leukocyte Cell-cell Adhesion Organ Development Membrane To Membrane Docking Positive Regulation Of Cellular Protein Metabolic Process Response To Organonitrogen Compound Regulation Of Cell-cell Adhesion Cell Differentiation Immune System Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Immune Response Regulation Of Phosphorylation Cell Activation Apoptotic Process Regulation Of Protein Metabolic Process Programmed Cell Death Regulation Of Immune Response System Development Response To Growth Factor Cell Death Anatomical Structure Development Death Response To External Stimulus Positive Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Catalytic Activity Multicellular Organismal Development Blood Coagulation Developmental Process Hemostasis Defense Response Response To Radiation Positive Regulation Of Phosphorylation Cellular Response To Growth Factor Stimulus Response To Stimulus Cell Development Regulation Of Body Fluid Levels
Tagcloud ?			actg2 adenomatous archived b4ganlt2 bank casp3 cdx1 cdx2 classifier cnn1 col1a1 custom fsp1 genomelab hcellmarkerplex house hybridisation incorporates krt18 lgr5 ms4a12 muc2 mucin nox1 ntn1 polyp signatures slc9a2 vwf
Tagcloud (Difference) ?			actg2 adenomatous archived b4ganlt2 bank casp3 cdx1 cdx2 classifier cnn1 col1a1 custom fsp1 genomelab hcellmarkerplex house hybridisation incorporates krt18 lgr5 ms4a12 muc2 mucin nox1 ntn1 polyp signatures slc9a2 vwf
Tagcloud (Intersection) ?