PALLD and SORBS2

Number of citations of the paper that reports this interaction (PubMedID 16125169)
0

Data Source:
BioGRID (two hybrid)

		PALLD	SORBS2
Description		palladin, cytoskeletal associated protein	sorbin and SH3 domain containing 2
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GO Annotations	Cellular Component	Stress Fiber Ruffle Podosome Nucleus Cytoplasm Mitochondrion Cytosol Cytoskeleton Actin Filament Plasma Membrane Focal Adhesion Actin Cytoskeleton Z Disc Lamellipodium Axon Growth Cone Cell Projection Excitatory Synapse Anchoring Junction	Nucleus Cytoplasm Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane Apical Plasma Membrane Z Disc Lamellipodium Dendrite Cell Projection Neuronal Cell Body Synapse Perinuclear Region Of Cytoplasm Anchoring Junction
	Molecular Function	Actin Binding Protein Binding Muscle Alpha-actinin Binding Cell-cell Adhesion Mediator Activity	RNA Binding Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Anchor Activity Structural Constituent Of Muscle Identical Protein Binding
	Biological Process	Keratinocyte Development Epithelial Cell Morphogenesis Cytoskeleton Organization Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Axon Guidance Cell Migration Actin Cytoskeleton Organization Dendrite Self-avoidance	Cytoskeleton Organization Notch Signaling Pathway Cell Growth Involved In Cardiac Muscle Cell Development
Pathways
Drugs
Diseases
GWAS		Bacteremia ( 27236921) Coronary artery disease ( 29212778 33020668) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Non-alcoholic fatty liver disease histology (AST) ( 20708005) Pulse pressure ( 27841878 28135244 30578418) Response to iloperidone treatment (QT prolongation) ( 18521091) Soluble receptor for advanced glycation end-product levels ( 26915486) Systolic blood pressure ( 30578418) Vein graft stenosis in coronary artery bypass grafting ( 25881214)	Cardiac Troponin-T levels ( 31014085) Coronary artery disease ( 33020668) Cytokine and corticosteroid-stimulated IL-6 production ( 25896417) Cytokine-stimulated IL-6 production ( 25896417) Height ( 31562340) LDL cholesterol levels in HIV infection ( 33109212) Short-term memory (digit-span task) ( 30741946) Triglyceride levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429) Uterine fibroid size (maximum volume) ( 30196971) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Interacting Genes		10 interacting genes: ACTN1 ACTN2 CDC42 EZR ITGB5 LIG4 PDLIM3 SORBS2 SRPK2 SUMO2	46 interacting genes: ABI1 ABL1 ABL2 ACTN1 ACTN4 ADAM15 AFDN AKT1 AKT2 ATPAF2 CBL CBLB DLGAP1 DLGAP2 DLGAP4 EFS EGFR EIF3H FAT1 FLOT1 GOLGA2 MDM2 NCK2 NR1H2 PAK1 PAK2 PALLD PKM PTK2B PTPN12 RPL9 SEMA6A SH2D4A SH3RF1 SHANK3 SOCS7 SYNJ1 TEPSIN TRAF4 VCL VPS37C WAS WASF1 WASL YWHAE YWHAZ
Entrez ID		23022	8470
HPRD ID		09731	12473
Ensembl ID		ENSG00000129116	ENSG00000154556
Uniprot IDs		A0A994J7A4 B2RTX2 Q8WX93	A0A8Q3WKF2 A0A8Q3WKH1 A0A8Q3WKK4 B7Z3D7 B7Z997 O94875
PDB IDs		2DM2 2DM3	5VEI
Enriched GO Terms of Interacting Partners?		Actin Filament-based Process Cytoskeletal Protein Binding Focal Adhesion Actin Cytoskeleton Organization Actin Filament Organization Cytoskeleton Organization Organelle Organization Actin Cytoskeleton Z Disc Structural Constituent Of Muscle Supramolecular Fiber Organization Actin Filament Bundle Assembly Actin Filament Bundle Organization Filopodium Actin Filament Actin Binding Pseudopodium Postsynaptic Actin Cytoskeleton Organization Establishment Of Epithelial Cell Apical/basal Polarity Postsynaptic Cytoskeleton Organization Integrin Binding Establishment Of Apical/basal Cell Polarity Filopodium Assembly Polarized Epithelial Cell Differentiation Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Focal Adhesion Assembly Establishment Of Epithelial Cell Polarity Actin Filament Binding Glutamatergic Synapse Cell-substrate Junction Assembly Cell-substrate Junction Organization Cellular Developmental Process Postsynapse Organization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cell Projection Cell Junction Assembly Establishment Or Maintenance Of Apical/basal Cell Polarity Cortical Actin Cytoskeleton Sarcomere Brush Border Actin Filament Uncapping Establishment Of Integrated Proviral Latency Platelet Alpha Granule Lumen Cell Differentiation Anatomical Structure Formation Involved In Morphogenesis Regulation Of Actin Cytoskeleton Organization Cell Adhesion Cellular Component Assembly Structural Constituent Of Postsynapse	Focal Adhesion Cytosol Lamellipodium Regulation Of Cell Motility SH3 Domain Binding Regulation Of Locomotion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Glutamatergic Synapse Regulation Of Cell Migration Cell-cell Junction Anchoring Junction Cadherin Binding Regulation Of Cellular Component Organization Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Cytoplasm Postsynaptic Density Actin Cytoskeleton Cellular Response To Growth Factor Stimulus ERBB Signaling Pathway Cell Migration Plasma Membrane Intracellular Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Response To Growth Factor Phosphotyrosine Residue Binding Regulation Of Signal Transduction Positive Regulation Of Cell Migration Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cell Motility Actin Polymerization Or Depolymerization Cell Surface Receptor Signaling Pathway Positive Regulation Of Locomotion Signal Transduction Cell Motility Actin Filament Organization Negative Regulation Of Signal Transduction Regulation Of Actin Filament Organization Supramolecular Fiber Organization Regulation Of Actin Filament-based Process Positive Regulation Of Cellular Component Organization Regulation Of Cell Adhesion Negative Regulation Of Signaling Regulation Of Lymphocyte Migration Developmental Process Negative Regulation Of Cell Communication Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cytoskeleton Organization
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