FOXL1 and BMPR2

Number of citations of the paper that reports this interaction (PMID 15188402)
20

Data Source:
HPRD (in vitro)

		FOXL1	BMPR2
Gene Name		forkhead box L1	bone morphogenetic protein receptor, type II (serine/threonine kinase)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Extracellular Space Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Caveola Basal Plasma Membrane Cell Surface Apical Plasma Membrane Dendrite Neuronal Cell Body Spanning Component Of Plasma Membrane
	Molecular Function	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity DNA Binding Sequence-specific DNA Binding Transcription Factor Activity DNA Binding, Bending Sequence-specific DNA Binding	Receptor Signaling Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Protein Binding ATP Binding Activin Receptor Activity, Type II Growth Factor Binding Metal Ion Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Visceral Mesoderm-endoderm Interaction Involved In Midgut Development Heart Development Organ Morphogenesis Regulation Of Wnt Signaling Pathway Proteoglycan Biosynthetic Process Peyer's Patch Morphogenesis	Mesoderm Formation Positive Regulation Of Endothelial Cell Proliferation Lymphangiogenesis Blood Vessel Remodeling Chondrocyte Development Negative Regulation Of Systemic Arterial Blood Pressure Transcription From RNA Polymerase II Promoter Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Brain Development Cellular Response To Starvation Anterior/posterior Pattern Specification Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Lung Blood Pressure Signal Transduction By Phosphorylation Proteoglycan Biosynthetic Process Negative Regulation Of Cell Growth Positive Regulation Of Bone Mineralization BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Activin Receptor Signaling Pathway Regulation Of Cell Proliferation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Vasoconstriction Vascular Endothelial Growth Factor Receptor Signaling Pathway Lung Alveolus Development Positive Regulation Of Axon Extension Involved In Axon Guidance Limb Development Endochondral Bone Morphogenesis Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Positive Regulation Of Cartilage Development Retina Vasculature Development In Camera-type Eye Negative Regulation Of Chondrocyte Proliferation Negative Regulation Of DNA Biosynthetic Process
Pathways			Signaling by BMP
Drugs
Diseases
GWAS		Bone mineral density ( 22504420) Bone mineral density (hip) ( 19801982) Bone mineral density (spine) ( 19801982) Obesity-related traits ( 23251661)	Urate levels ( 23263486)
Protein-Protein Interactions		1 interactors: BMPR2	49 interactors: ACTR8 ACVR1 ACVR1B ARSA BMP10 BMP2 BMP4 BMP6 BMP7 BMPR1A BMPR1B C4BPA CCDC89 CES1 CRYAB CTBP1 DYNLT1 FHL2 FOXL1 FRS3 GDF2 GDF5 GDF6 GDF9 HNRNPR LIMK1 LMX1A LSM10 LSP1 MAP3K8 MAPK8 MERTK MOS NBEA NOP56 PDZRN3 PMPCA PPP1CC PRKCB RABGGTA SULT1E1 TGFBR1 TOPBP1 TRIB3 TRPC1 TSR1 TUBB TUBB4A TWF1
Entrez ID		2300	659
HPRD ID		07219	02880
Ensembl ID		ENSG00000176678	ENSG00000204217
Uniprot IDs		Q12952 Q498Y4	Q13873
PDB IDs			2HLQ 3G2F
Enriched GO Terms of Interacting Partners?		Regulation Of Lung Blood Pressure Negative Regulation Of Chondrocyte Proliferation Negative Regulation Of Vasoconstriction Positive Regulation Of Axon Extension Involved In Axon Guidance Lymphatic Endothelial Cell Differentiation Lymphangiogenesis Lymph Vessel Morphogenesis Regulation Of Axon Extension Involved In Axon Guidance Venous Blood Vessel Development Retina Vasculature Development In Camera-type Eye Lymph Vessel Development Negative Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of DNA Biosynthetic Process Activin Receptor Signaling Pathway Chondrocyte Development Positive Regulation Of BMP Signaling Pathway Positive Regulation Of Axon Extension Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Cartilage Development Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Blood Vessel Remodeling Regulation Of DNA Biosynthetic Process Negative Regulation Of Blood Pressure Lung Alveolus Development Regulation Of Pathway-restricted SMAD Protein Phosphorylation Proteoglycan Biosynthetic Process Positive Regulation Of Endothelial Cell Migration Regulation Of Vasoconstriction Positive Regulation Of Endothelial Cell Proliferation Artery Development Regulation Of Axon Extension Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Axonogenesis BMP Signaling Pathway Endothelial Cell Differentiation Positive Regulation Of Epithelial Cell Migration Regulation Of BMP Signaling Pathway Endochondral Bone Morphogenesis Regulation Of Endothelial Cell Proliferation Chondrocyte Differentiation Mesoderm Formation Regulation Of Cartilage Development Endothelium Development Mesoderm Morphogenesis Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of DNA Metabolic Process Positive Regulation Of Ossification Vascular Endothelial Growth Factor Receptor Signaling Pathway	Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation BMP Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway SMAD Protein Signal Transduction Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Protein Modification Process Positive Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Activin Receptor Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Ossification Protein Phosphorylation Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Cell Development Regulation Of Bone Mineralization Regulation Of MAPK Cascade Regulation Of Osteoblast Differentiation Regulation Of Phosphorylation Regulation Of Cell Differentiation Phosphorylation Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Phosphorus Metabolic Process Growth Signal Transduction By Phosphorylation Regulation Of Signal Transduction Cartilage Development Regulation Of Ossification Positive Regulation Of Cell Differentiation Regulation Of Cellular Component Organization Regulation Of Signaling Regulation Of Cartilage Development Regulation Of Growth Cell Surface Receptor Signaling Pathway Connective Tissue Development Positive Regulation Of Cartilage Development Phosphate-containing Compound Metabolic Process Peptidyl-threonine Phosphorylation Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Modification Process Response To Stimulus
Tagcloud ?		bmd chungju esr1 femur gwass korea lrp5 lumbar mef2c postmenopausal rs10048146 rs1004816 rs1366594 rs2073617 rs227438 rs2277438 rs2941740 rs3134070 rs599083 rs6426749 rs711785 rs7117858 rs711858 rs9594782 snps sox6 tnfrsf11b tnfsf11 zbtb40	apoptotic autophagy bmprs bmps chondrosarcoma chondrosarcomas clinicopathological crucial dedifferentiated eventually find g2 inconsistent interfering mdm2 morphogenetic multifunctional predict prevalent promoted protective repression sensitized silencing somewhat tumorigenesis tumorigenicity xiap
Tagcloud (Difference) ?		bmd chungju esr1 femur gwass korea lrp5 lumbar mef2c postmenopausal rs10048146 rs1004816 rs1366594 rs2073617 rs227438 rs2277438 rs2941740 rs3134070 rs599083 rs6426749 rs711785 rs7117858 rs711858 rs9594782 snps sox6 tnfrsf11b tnfsf11 zbtb40	apoptotic autophagy bmprs bmps chondrosarcoma chondrosarcomas clinicopathological crucial dedifferentiated eventually find g2 inconsistent interfering mdm2 morphogenetic multifunctional predict prevalent promoted protective repression sensitized silencing somewhat tumorigenesis tumorigenicity xiap
Tagcloud (Intersection) ?