RAB26 and GCH1

Number of citations of the paper that reports this interaction (PubMedID 16696853)
38

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RAB26	GCH1
Description		RAB26, member RAS oncogene family	GTP cyclohydrolase 1
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GO Annotations	Cellular Component	Golgi Membrane Endosome Golgi Apparatus Plasma Membrane Membrane Transport Vesicle Membrane Secretory Granule Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Vesicle Nuclear Membrane Protein-containing Complex Neuron Projection Terminus
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity GMP Binding Metal Ion Binding	Nucleotide Binding Catalytic Activity GTPase Activity GTP Cyclohydrolase I Activity Protein Binding GTP Binding Zinc Ion Binding Hydrolase Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Mitogen-activated Protein Kinase Binding
	Biological Process	Protein Transport Regulation Of Exocytosis Exocrine System Development Golgi To Plasma Membrane Protein Transport Regulated Exocytosis Regulation Protein Catabolic Process At Presynapse	Tetrahydrobiopterin Biosynthetic Process Nitric Oxide Biosynthetic Process Regulation Of Blood Pressure Positive Regulation Of Heart Rate Regulation Of Lung Blood Pressure Response To Lipopolysaccharide Response To Type II Interferon Response To Tumor Necrosis Factor Dopamine Biosynthetic Process Pteridine-containing Compound Metabolic Process Pteridine-containing Compound Biosynthetic Process Tetrahydrobiopterin Metabolic Process Tetrahydrofolate Biosynthetic Process Response To Pain Neuromuscular Process Controlling Posture Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Removal Of Superoxide Radicals
Pathways		RAB geranylgeranylation	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Drugs			Guanine
Diseases			Primary torsion dystonia (PTD) Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient
GWAS		Hip circumference adjusted for BMI ( 34021172)	Chronotype ( 30696823) Mercury levels ( 26025379) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Parkinson's disease ( 25064009 27182965 28892059 32201043) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Rheumatoid arthritis ( 22446963) Serum metabolite levels ( 33031748)
Interacting Genes		8 interacting genes: APP FHL5 GCH1 KRT33B OIP5 RIMS1 SNCA UNKL	15 interacting genes: AHSA1 ATP1B1 CDC37 CNRIP1 GCHFR GIT2 HSPA8 RAB26 RLF RPH3A SH3GL2 SP3 TNPO2 TNPO3 YWHAZ
Entrez ID		25837	2643
HPRD ID		05676	02573
Ensembl ID		ENSG00000167964	ENSG00000131979
Uniprot IDs		Q9ULW5	P30793 Q8IZH9
PDB IDs		2G6B	1FB1 6Z80 6Z85 6Z86 6Z87 6Z88 6Z89 7ALA 7ALB 7ALC 7ALQ
Enriched GO Terms of Interacting Partners?		Regulation Of Presynapse Organization Response To Copper Ion Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Presynapse Assembly Amyloid Fibril Formation Regulation Of Superoxide Metabolic Process Regulation Of Neurotransmitter Uptake Microglial Cell Activation Leukocyte Activation Involved In Inflammatory Response Cellular Response To Copper Ion Catecholamine Biosynthetic Process Biogenic Amine Biosynthetic Process Dopamine Biosynthetic Process Dopamine Metabolic Process Synaptic Vesicle Priming Synaptic Vesicle Exocytosis Metal Ion Binding Amine Biosynthetic Process Synapse Organization Catecholamine Metabolic Process Modulation Of Excitatory Postsynaptic Potential Amyloid-beta Complex Regulation Of Neuronal Synaptic Plasticity Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Macrophage Activation Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process Biogenic Amine Metabolic Process GTP Cyclohydrolase I Activity Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Amine Metabolic Process Adult Locomotory Behavior Response To Interleukin-1 Phenol-containing Compound Metabolic Process Regulation Of Neurotransmitter Secretion Zinc Ion Binding Acetylcholine Receptor Activator Activity Regulation Of Membrane Potential Protein Tetramerization Lipoprotein Particle Positive Regulation Of Protein Import Response To Type II Interferon	Establishment Of Localization In Cell GMP Binding Regulation Of Protein Stability Establishment Of Protein Localization Cellular Localization Extrinsic Component Of Synaptic Vesicle Membrane Protein Targeting Protein Kinase Binding ATPase Activator Activity Intracellular Protein Localization MHC Class II Protein Complex Binding Protein Transport Melanosome Protein-folding Chaperone Binding Unfolded Protein Binding Small GTPase Binding Nuclear Import Signal Receptor Activity Import Into Nucleus Intracellular Protein Transport Protein Folding Chaperone Complex Intracellular Transport GTP Cyclohydrolase I Regulator Activity GTP Cyclohydrolase Binding Chaperone-mediated Autophagy Translocation Complex Disassembly Establishment Of Protein Localization To Organelle Exocrine System Development Type 1 Cannabinoid Receptor Binding ATP Metabolic Process Hsp90 Protein Binding
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