MAST1 and CYP2C8

Number of citations of the paper that reports this interaction (PMID 21163940)
13

Data Source:
BioGRID (two hybrid)

		MAST1	CYP2C8
Gene Name		microtubule associated serine/threonine kinase 1	cytochrome P450, family 2, subfamily C, polypeptide 8
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Gene Ontology Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane	Cytoplasm Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding	Monooxygenase Activity Iron Ion Binding Arachidonic Acid Epoxygenase Activity Steroid Hydroxylase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Oxygen Binding Heme Binding Caffeine Oxidase Activity Aromatase Activity
	Biological Process	Protein Phosphorylation Cytoskeleton Organization Intracellular Signal Transduction	Organic Acid Metabolic Process Xenobiotic Metabolic Process Drug Metabolic Process Arachidonic Acid Metabolic Process Epoxygenase P450 Pathway Exogenous Drug Catabolic Process Small Molecule Metabolic Process Oxidation-reduction Process Oxidative Demethylation Omega-hydroxylase P450 Pathway
Pathways			Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolism of lipids and lipoproteins Metabolic disorders of biological oxidation enzymes Phase 1 - Functionalization of compounds Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Arachidonic acid metabolism Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type CYP2E1 reactions Biological oxidations Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective FMO3 causes Trimethylaminuria (TMAU) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Defective CYP1B1 causes Glaucoma Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Xenobiotics Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
Drugs
Diseases
GWAS			Immune response to smallpox vaccine (IL-6) ( 22542470) Osteonecrosis of the jaw ( 18594024) Response to clopidogrel therapy ( 19706858) Warfarin maintenance dose ( 23755828)
Protein-Protein Interactions		37 interactors: A2M AP1M2 APOE APP BLMH CDK5 CYP2C8 CYP2C9 DNAJB1 ECSIT EGFR ELAVL3 EXOC6 EXOSC1 FBXL12 FBXW4 GCDH IFIT3 IFIT5 LONP1 LOXL4 MGEA5 NOS3 PAXIP1 PRAM1 PRDX2 PSEN2 PTEN RAB3A RAB3D RAD23A RNF32 RNLS RPP30 SNTA1 SNTB2 STAMBPL1	11 interactors: A2M APOE BLMH DNAJB1 ECSIT EXOC6 IFIT3 LONP1 MAST1 PSEN1 RNF32
Entrez ID		22983	1558
HPRD ID		17469	03083
Ensembl ID		ENSG00000105613	ENSG00000138115
Uniprot IDs		Q9Y2H9	B7Z1F5 P10632
PDB IDs		2M9X 3PS4	1PQ2 2NNH 2NNI 2NNJ 2VN0
Enriched GO Terms of Interacting Partners?		Catabolic Process Synapse Organization Negative Regulation Of Protein Metabolic Process Response To Stress Negative Regulation Of Cellular Protein Metabolic Process Response To Abiotic Stimulus Negative Regulation Of Presynaptic Membrane Organization Regulation Of Synaptic Plasticity Regulation Of Synaptic Transmission Regulation Of Oxidoreductase Activity Synapse Assembly Exocytosis Regulation Of Cellular Protein Metabolic Process Axon Development Response To Stimulus Regulation Of Presynaptic Membrane Organization Regulation Of Nitric-oxide Synthase Activity Regulation Of Protein Metabolic Process Negative Regulation Of Dendritic Spine Development Learning Or Memory Regulation Of Proteolysis Regulation Of Dendritic Spine Development Negative Regulation Of Cell Death Cognition Omega-hydroxylase P450 Pathway Synaptic Vesicle Exocytosis Anatomical Structure Morphogenesis Secretion By Cell Vesicle Docking Involved In Exocytosis Axonogenesis Positive Regulation Of Exocytosis Neuron Projection Development Vesicle-mediated Transport Glial Cell Differentiation Protein Metabolic Process Establishment Of Protein Localization Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cell Morphogenesis Involved In Neuron Differentiation Negative Regulation Of Neuron Differentiation Membrane Organization Oxidative Demethylation Protein Catabolic Process Establishment Of Vesicle Localization Oligodendrocyte Differentiation Positive Regulation Of Catalytic Activity Regulation Of ERBB Signaling Pathway Vesicle Docking Regulation Of Cellular Amino Acid Metabolic Process Endothelial Cell Migration Vesicle Localization	Regulation Of Inclusion Body Assembly Response To Stress Protein Metabolic Process Exocytosis Oxidation-dependent Protein Catabolic Process Cajal-Retzius Cell Differentiation Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Positive Regulation Of Dendritic Spine Maintenance Negative Regulation Of Dendritic Spine Maintenance Negative Regulation Of Phospholipid Efflux Negative Regulation Of Lipid Transport Across Blood Brain Barrier Positive Regulation Of Lipid Transport Across Blood Brain Barrier Beta-amyloid Formation Positive Regulation Of Postsynaptic Membrane Organization Negative Regulation Of Postsynaptic Membrane Organization Regulation Of Oxidoreductase Activity Response To Stimulus Response To Oxidative Stress Regulation Of Cellular Component Organization Extracellular Matrix Disassembly Establishment Of Localization In Cell Positive Regulation Of Neurofibrillary Tangle Assembly Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Complement Activation, Lectin Pathway Negative Regulation Of Presynaptic Membrane Organization Positive Regulation Of Presynaptic Membrane Organization Cellular Response To Stimulus Secretion By Cell Immune System Process Negative Regulation Of Neuron Projection Development Positive Regulation Of Phospholipid Efflux Negative Regulation Of Cholesterol Biosynthetic Process Regulation Of Mitochondrial DNA Replication Regulation Of Postsynaptic Membrane Organization Very-low-density Lipoprotein Particle Clearance Negative Regulation Of Cell Projection Organization Regulation Of Catalytic Activity Synaptic Vesicle Targeting Regulation Of Resting Membrane Potential Cellular Localization Positive Regulation Of Cellular Protein Catabolic Process Maintenance Of Location In Cell Regulation Of Axonogenesis Secretion Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Regulation Of Tau-protein Kinase Activity Response To Aluminum Ion Negative Regulation Of Cholesterol Efflux N-methyl-D-aspartate Receptor Clustering Regulation Of Presynaptic Membrane Organization
Tagcloud ?			allele apolipoprotein associations cardiotoxicity commonly comt conform epsilon4 failed fatigue genetic genotype guidelines il6 impairment listed lle655val met neuropathy polymorphisms reporting strega systematic toxicities transparent underlying val variant variants
Tagcloud (Difference) ?			allele apolipoprotein associations cardiotoxicity commonly comt conform epsilon4 failed fatigue genetic genotype guidelines il6 impairment listed lle655val met neuropathy polymorphisms reporting strega systematic toxicities transparent underlying val variant variants
Tagcloud (Intersection) ?