KHDC4 and PIDD1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KHDC4	PIDD1
Description		KH domain containing 4, pre-mRNA splicing factor	p53-induced death domain protein 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol Endopeptidase Complex
	Molecular Function	RNA Binding Protein Binding	Endopeptidase Activity Death Receptor Binding Protein Binding Hydrolase Activity
	Biological Process	MRNA Splice Site Recognition MRNA Processing RNA Splicing	Apoptotic Process DNA Damage Response Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Protein Autoprocessing DNA Damage Response, Signal Transduction By P53 Class Mediator Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway
Pathways			TP53 Regulates Transcription of Caspase Activators and Caspases
Drugs
Diseases
GWAS			Breast cancer ( 29059683)
Interacting Genes		21 interacting genes: BANP C14orf119 DNAJC5 KCNIP3 MAGEA12 NRF1 NUTF2 PIDD1 PRKAB2 PRR13 PSMB1 PUF60 QRICH1 RBM23 RBM39 RHOXF2 SAT1 SPANXN2 U2AF2 ZDHHC17 ZRSR2	17 interacting genes: AFP ATM CASP2 CCDC85B CRADD EFEMP2 FADD HSD17B14 KHDC4 MADD MAFG MDFI MTNR1B POGZ PRKDC SOX8 TEAD3
Entrez ID		22889	55367
HPRD ID		17198	11284
Ensembl ID		ENSG00000132680	ENSG00000177595
Uniprot IDs		Q7Z7F0	Q9HB75
PDB IDs		2YQR	2OF5
Enriched GO Terms of Interacting Partners?		Pre-mRNA 3'-splice Site Binding U2AF Complex Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome U1 SnRNP Binding RNA Splicing Regulation Of RNA Splicing MRNA Processing Nucleus Nucleic Acid Binding Regulation Of MRNA Metabolic Process MRNA Metabolic Process Spermidine Binding Perforant Pathway To Dendrate Granule Cell Synapse Spermidine Acetylation Putrescine Catabolic Process MRNA Splicing, Via Spliceosome Spliceosomal Complex Assembly Protein-RNA Complex Assembly RNA Splicing, Via Transesterification Reactions Poly-pyrimidine Tract Binding Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Nucleoplasm RNA Processing Diamine N-acetyltransferase Activity Protein Localization To Nuclear Pore Endopeptidase Complex Identical Protein Binding	DNA-dependent Protein Kinase Activity Histone H2AXS139 Kinase Activity Endopeptidase Complex Cell Death Programmed Cell Death Signal Transduction In Response To DNA Damage DNA Damage Response, Signal Transduction By P53 Class Mediator Apoptotic Signaling Pathway Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cellular Response To Mechanical Stimulus Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death V(D)J Recombination Signal Transduction By P53 Class Mediator Positive Regulation Of Transcription By RNA Polymerase II Ectopic Germ Cell Programmed Cell Death Death Receptor Binding Reproductive Process Extrinsic Apoptotic Signaling Pathway Programmed Cell Death Involved In Cell Development Execution Phase Of Apoptosis Double-strand Break Repair Via Homologous Recombination Recombinational Repair Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of RNA Biosynthetic Process Intrinsic Apoptotic Signaling Pathway Positive Regulation Of DNA-templated Transcription Cell Fate Commitment Cellular Developmental Process Ovulation Cycle Process Somitogenesis Peptidyl-serine Phosphorylation DNA Damage Response Somatic Cell DNA Recombination Response To Mechanical Stimulus T Cell Differentiation In Thymus Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Positive Regulation Of Smooth Muscle Cell-matrix Adhesion D-threo-aldose 1-dehydrogenase Activity Thymus Development Positive Regulation Of RNA Metabolic Process Double-strand Break Repair Developmental Process Involved In Reproduction Regulation Of DNA-templated Transcription
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