KHDC4 and DNAJC5

Number of citations of the paper that reports this interaction (PubMedID 29997244)
64

Data Source:
BioGRID (fluorescent resonance energy transfer)

		KHDC4	DNAJC5
Description		KH domain containing 4, pre-mRNA splicing factor	DnaJ heat shock protein family (Hsp40) member C5
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm	Cytoplasm Mitochondrion Lysosomal Membrane Cytosol Plasma Membrane Synaptic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Neuromuscular Junction Azurophil Granule Membrane Specific Granule Membrane Melanosome Chromaffin Granule Membrane Intracellular Membrane-bounded Organelle Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Presynapse
	Molecular Function	RNA Binding Protein Binding	Protein Binding ATP-dependent Protein Binding
	Biological Process	MRNA Splice Site Recognition MRNA Processing RNA Splicing	Protein Folding Exocytosis Synaptic Vesicle Exocytosis Negative Regulation Of Neuron Apoptotic Process Regulated Exocytosis Neuron Apoptotic Process Regulation Of Synaptic Vesicle Cycle
Pathways			Neutrophil degranulation GABA synthesis, release, reuptake and degradation Sensory processing of sound by inner hair cells of the cochlea
Drugs
Diseases
GWAS			Immature fraction of reticulocytes ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Prostate cancer ( 23535732)
Interacting Genes		21 interacting genes: BANP C14orf119 DNAJC5 KCNIP3 MAGEA12 NRF1 NUTF2 PIDD1 PRKAB2 PRR13 PSMB1 PUF60 QRICH1 RBM23 RBM39 RHOXF2 SAT1 SPANXN2 U2AF2 ZDHHC17 ZRSR2	49 interacting genes: AGFG1 AP2B1 ARHGEF15 BTC CADM1 CADPS CD2 CFTR CGB5 CLCN3 ERC1 FAS FCHO1 GRM8 HBA2 KHDC4 LIN7A LIN7C NECAP1 NRXN3 PPFIA4 PRKACA PRKCG PRRC2B PSMD12 RABGEF1 RBSN SCAMP3 SCAMP5 SH3GL3 SLC17A8 SLC18A2 SLC30A3 SLC32A1 SNAP29 SNAP91 SNCA STX12 STX3 STX4 STX6 SV2A SYT12 SYT5 SYT9 VAMP1 VAMP3 VAMP4 VAMP7
Entrez ID		22889	80331
HPRD ID		17198	08539
Ensembl ID		ENSG00000132680	ENSG00000101152
Uniprot IDs		Q7Z7F0	Q9H3Z4
PDB IDs		2YQR	2N04 2N05
Enriched GO Terms of Interacting Partners?		Pre-mRNA 3'-splice Site Binding U2AF Complex Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome U1 SnRNP Binding RNA Splicing Regulation Of RNA Splicing MRNA Processing Nucleus Nucleic Acid Binding Regulation Of MRNA Metabolic Process MRNA Metabolic Process Spermidine Binding Perforant Pathway To Dendrate Granule Cell Synapse Spermidine Acetylation Putrescine Catabolic Process MRNA Splicing, Via Spliceosome Spliceosomal Complex Assembly Protein-RNA Complex Assembly RNA Splicing, Via Transesterification Reactions Poly-pyrimidine Tract Binding Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Nucleoplasm RNA Processing Diamine N-acetyltransferase Activity Protein Localization To Nuclear Pore Endopeptidase Complex Identical Protein Binding	Synaptic Vesicle Membrane Vesicle-mediated Transport Synapse SNARE Binding Neurotransmitter Transport SNARE Complex Secretion By Cell Exocytosis Cytoplasmic Vesicle Establishment Of Localization In Cell SNAP Receptor Activity Synaptic Vesicle Secretion Regulation Of Vesicle-mediated Transport Presynapse Protein Transport Regulation Of Exocytosis Plasma Membrane Membrane Establishment Of Protein Localization Organelle Fusion SNARE Complex Assembly Neuron Projection Vesicle Fusion Organelle Membrane Fusion Clathrin-coated Endocytic Vesicle Membrane Vesicle Organization Neurotransmitter Secretion Organelle Localization By Membrane Tethering Regulation Of Regulated Secretory Pathway Phagocytic Vesicle Glutamatergic Synapse Regulation Of Secretion By Cell Organelle Localization Membrane Docking Vesicle-mediated Transport In Synapse Membrane Fusion Regulation Of Secretion Recycling Endosome Membrane Endosome Signal Release Vesicle Docking Intracellular Protein Localization Regulation Of Transport Positive Regulation Of Exocytosis Membrane Organization Regulation Of Endocytosis Chemical Synaptic Transmission Trans-synaptic Signaling Long-term Synaptic Potentiation
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