FGB and CSNK2B

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		FGB	CSNK2B
Gene Name		fibrinogen beta chain	casein kinase 2, beta polypeptide
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Fibrinogen Complex Extracellular Space Plasma Membrane Cell Cortex External Side Of Plasma Membrane Cell Surface Platelet Alpha Granule Platelet Alpha Granule Lumen Vesicle Extracellular Vesicular Exosome Blood Microparticle	Nucleus Cytoplasm Cytosol Plasma Membrane Protein Kinase CK2 Complex PcG Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Receptor Binding Structural Molecule Activity Protein Binding Protein Binding, Bridging Cell Adhesion Molecule Binding Chaperone Binding	Protein Serine/threonine Kinase Activity Receptor Binding Protein Binding Transcription Factor Binding Protein Kinase Regulator Activity Protein Domain Specific Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Platelet Degranulation Cell-matrix Adhesion Signal Transduction Blood Coagulation Platelet Activation Extracellular Matrix Organization Positive Regulation Of Heterotypic Cell-cell Adhesion Cellular Protein Complex Assembly Cellular Response To Leptin Stimulus Innate Immune Response Positive Regulation Of Vasoconstriction Positive Regulation Of Exocytosis Positive Regulation Of Protein Secretion Protein Polymerization Response To Calcium Ion Positive Regulation Of ERK1 And ERK2 Cascade Platelet Aggregation Cellular Response To Interleukin-1 Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Endothelial Cell Apoptotic Process	Mitotic Cell Cycle Protein Phosphorylation Signal Transduction Axon Guidance Negative Regulation Of Cell Proliferation Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Wnt Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Adiponectin-activated Signaling Pathway Negative Regulation Of Blood Vessel Endothelial Cell Migration Cellular Protein Complex Assembly Regulation Of Protein Kinase Activity Regulation Of DNA Binding Endothelial Tube Morphogenesis
Pathways		p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling GRB2:SOS provides linkage to MAPK signaling for Integrins Platelet degranulation Platelet Aggregation (Plug Formation) Formation of Fibrin Clot (Clotting Cascade) Common Pathway Response to elevated platelet cytosolic Ca2+ Integrin cell surface interactions Platelet activation, signaling and aggregation	Mitotic Prometaphase Signal transduction by L1 Axon guidance misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling L1CAM interactions Signaling by Wnt Cell Cycle, Mitotic M Phase WNT mediated activation of DVL TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer Condensation of Prometaphase Chromosomes
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Fibrinogen ( 20031576 20031577 21757653)
Protein-Protein Interactions		15 interactors: AIMP2 ANXA7 CALR CDKN1A CSNK2B FBLN1 FGA FGG GRB7 LPA NID1 PIK3R3 SERPINA5 SMN1 TK1	175 interactors: ABHD4 ACTB ACTL6B ACTR1B ACTR5 ACVRL1 ADD1 ADH5 ADRBK1 ANGPT2 ANKRD28 AP2M1 APLP1 ARAF ATF1 ATG101 ATXN3 BAG6 BCCIP BID BMI1 BRCA1 BTF3 C6orf136 C9orf114 CACNA1A CALM1 CBX4 CCDC115 CCNH CD163 CD81 CDC25B CDC34 CDK1 CDK20 CDKN1A CENPB CHEK1 CHRNA4 CIC COIL COL4A2 COPS2 COPS3 COPS7A CPNE7 CPSF3L CSN1S1 CSN2 CSNK2A1 CSNK2A2 CTDP1 CTNNB1 DACT1 DALRD3 DENND5A DNMT1 EIF2S2 EIF5 EIF6 EPS8 ERCC8 ESR1 FAF1 FBXL5 FGB FGF1 FGF2 FIBP FKBP3 FTH1 GADD45GIP1 GAMT GBP2 GLB1 GNB5 HEXB HIRIP3 HNRNPA2B1 HOXB6 HTRA1 IER3IP1 IRS1 ITSN1 JUN KDM6B KIF2C LCK LEPR LMO4 LRP5L LYN LYST MAPK14 MBD4 MGEA5 MME MOXD1 MPP2 NAP1L1 NCF1 NMT2 NOLC1 NOTCH3 NRBP1 ODC1 PDS5A PFKFB4 PHC2 PHF11 PHRF1 PIN1 PITPNA PLXNA3 POT1 PPID PPP3CC PRKAB2 PRKCZ PRNP PROC PTPRK PYROXD2 RFC1 RNF126 RNF7 RPA1 RPL13 RPL41 RPL5 RPS6KA2 RPS6KA5 RPS6KB1 RPS6KB2 RRAD RXRA SARNP SDHA SEC11A SHANK3 SHMT1 SHMT2 SIMC1 SIRT1 SNX2 SPSB3 SSB STAT5A STAU1 STK16 SUMO2 SYNE4 TCEAL7 TCTEX1D2 TLE1 TNFAIP1 TOP2B TP53 TP53BP2 TSEN54 TUBB2B UBE2I UPF1 USO1 UTP14A VDAC1 VRK3 WDR1 WDR18 WFIKKN1 ZNF44 ZNF71 ZNF784 ZNHIT1
Entrez ID		2244	1460
HPRD ID		00620	00278
Ensembl ID			ENSG00000204435
Uniprot IDs		P02675	N0E4C7 P67870 Q5SRQ6
PDB IDs		1FZA 1FZB 1FZC 1FZE 1FZF 1FZG 1LT9 1LTJ 1N86 1N8E 1RE3 1RE4 1RF0 1RF1 2A45 2FFD 2H43 2HLO 2HOD 2HPC 2OYH 2OYI 2Q9I 2XNX 2XNY 2Z4E 3BVH 3E1I 3GHG 3H32 3HUS	1DS5 1JWH 1QF8 3EED 4DGL
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Cell-substrate Adhesion Regulation Of Substrate Adhesion-dependent Cell Spreading Response To Metal Ion Regulation Of Protein Metabolic Process Cellular Macromolecular Complex Assembly Hemostasis Regulation Of Cell-substrate Adhesion Response To Inorganic Substance Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Positive Regulation Of Heterotypic Cell-cell Adhesion Regulation Of Body Fluid Levels Cellular Protein Complex Assembly Response To Calcium Ion Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Cell Adhesion Cellular Component Assembly Regulation Of Phosphorylation Negative Regulation Of Cellular Protein Metabolic Process Blood Coagulation Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Phosphorylation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Metabolic Process Cell-matrix Adhesion Cellular Senescence Regulation Of Phosphorus Metabolic Process Regulation Of Cell Morphogenesis Positive Regulation Of Vasoconstriction Response To Hormone Regulation Of Endothelial Cell Apoptotic Process Platelet Aggregation Regulation Of Catalytic Activity Protein Complex Assembly Cell-substrate Adhesion Wound Healing Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Adhesion Regulation Of Vasoconstriction Negative Regulation Of Blood Coagulation, Common Pathway Blood Coagulation, Common Pathway Peptide Antigen Assembly With MHC Class I Protein Complex Fetal Process Involved In Parturition Positive Regulation Of Protein Metabolic Process Positive Regulation Of Exocytosis	Cellular Metabolic Process Response To Growth Factor Regulation Of Protein Metabolic Process Cellular Response To Growth Factor Stimulus Developmental Process Cellular Response To Organic Substance Regulation Of Cellular Protein Metabolic Process Cellular Protein Metabolic Process Multicellular Organismal Development Regulation Of Cell Proliferation Anatomical Structure Development Metabolic Process Response To Organic Substance Regulation Of Cellular Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Macromolecule Biosynthetic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Cycle Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process System Development Response To Stress Neurotrophin TRK Receptor Signaling Pathway Response To Stimulus Cell Cycle Positive Regulation Of Protein Metabolic Process Neurotrophin Signaling Pathway Nitrogen Compound Metabolic Process Biosynthetic Process Cellular Protein Modification Process Cellular Response To Stimulus Cell Death Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Death Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Response To Radiation Response To Radiation Positive Regulation Of Cell Proliferation Heterocycle Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Apoptotic Process Cellular Response To Light Stimulus Gene Expression Regulation Of Phosphorylation Peptidyl-amino Acid Modification Programmed Cell Death Cellular Aromatic Compound Metabolic Process
Tagcloud ?		assigned correlations decreasing delta deltafbg deltahoma diagnosed dipeptidyl dpp effectively efficacies fasting glycemic hba1c homa homeostasis hypoglycemic japanese monotherapy naive newly noted peptidase reductions safely t2dm teneligliptin ua uric	bovine casein catalytic cattle chromosome chromosomes coast composed conserved defined east encoding fever genomes homology hybrid mapped panel parasitic polymerase rodent segment somatic subunit subunits synteny theileriosis
Tagcloud (Difference) ?		assigned correlations decreasing delta deltafbg deltahoma diagnosed dipeptidyl dpp effectively efficacies fasting glycemic hba1c homa homeostasis hypoglycemic japanese monotherapy naive newly noted peptidase reductions safely t2dm teneligliptin ua uric	bovine casein catalytic cattle chromosome chromosomes coast composed conserved defined east encoding fever genomes homology hybrid mapped panel parasitic polymerase rodent segment somatic subunit subunits synteny theileriosis
Tagcloud (Intersection) ?