FGB and FGG

Number of citations of the paper that reports this interaction (PMID 12356313)
12

Data Source:
HPRD (in vitro)

		FGB	FGG
Gene Name		fibrinogen beta chain	fibrinogen gamma chain
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Fibrinogen Complex Extracellular Space Plasma Membrane Cell Cortex External Side Of Plasma Membrane Cell Surface Platelet Alpha Granule Platelet Alpha Granule Lumen Vesicle Extracellular Vesicular Exosome Blood Microparticle	Extracellular Region Fibrinogen Complex Extracellular Space Plasma Membrane Cell Cortex External Side Of Plasma Membrane Cell Surface Platelet Alpha Granule Platelet Alpha Granule Lumen Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Receptor Binding Structural Molecule Activity Protein Binding Protein Binding, Bridging Cell Adhesion Molecule Binding Chaperone Binding	Receptor Binding Structural Molecule Activity Protein Binding, Bridging Metal Ion Binding Cell Adhesion Molecule Binding
	Biological Process	Platelet Degranulation Cell-matrix Adhesion Signal Transduction Blood Coagulation Platelet Activation Extracellular Matrix Organization Positive Regulation Of Heterotypic Cell-cell Adhesion Cellular Protein Complex Assembly Cellular Response To Leptin Stimulus Innate Immune Response Positive Regulation Of Vasoconstriction Positive Regulation Of Exocytosis Positive Regulation Of Protein Secretion Protein Polymerization Response To Calcium Ion Positive Regulation Of ERK1 And ERK2 Cascade Platelet Aggregation Cellular Response To Interleukin-1 Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Endothelial Cell Apoptotic Process	Platelet Degranulation Cell-matrix Adhesion Signal Transduction Blood Coagulation Platelet Activation Extracellular Matrix Organization Positive Regulation Of Heterotypic Cell-cell Adhesion Cellular Protein Complex Assembly Positive Regulation Of Vasoconstriction Positive Regulation Of Exocytosis Positive Regulation Of Protein Secretion Protein Polymerization Response To Calcium Ion Positive Regulation Of ERK1 And ERK2 Cascade Platelet Aggregation Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling GRB2:SOS provides linkage to MAPK signaling for Integrins Platelet degranulation Platelet Aggregation (Plug Formation) Formation of Fibrin Clot (Clotting Cascade) Common Pathway Response to elevated platelet cytosolic Ca2+ Integrin cell surface interactions Platelet activation, signaling and aggregation	p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling GRB2:SOS provides linkage to MAPK signaling for Integrins Platelet degranulation Platelet Aggregation (Plug Formation) Formation of Fibrin Clot (Clotting Cascade) Common Pathway Response to elevated platelet cytosolic Ca2+ Integrin cell surface interactions Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Fibrinogen ( 20031576 20031577 21757653)	D-dimer levels ( 21502573) Fibrinogen ( 20031577 21757653) Venous thromboembolism ( 21980494 23650146)
Protein-Protein Interactions		15 interactors: AIMP2 ANXA7 CALR CDKN1A CSNK2B FBLN1 FGA FGG GRB7 LPA NID1 PIK3R3 SERPINA5 SMN1 TK1	10 interactors: F13A1 F13B FGA FGB ICAM1 ITGAM ITGB3 SERPINA5 VKORC1 VTN
Entrez ID		2244	2266
HPRD ID		00620	00621
Ensembl ID			ENSG00000171557
Uniprot IDs		P02675	P02679
PDB IDs		1FZA 1FZB 1FZC 1FZE 1FZF 1FZG 1LT9 1LTJ 1N86 1N8E 1RE3 1RE4 1RF0 1RF1 2A45 2FFD 2H43 2HLO 2HOD 2HPC 2OYH 2OYI 2Q9I 2XNX 2XNY 2Z4E 3BVH 3E1I 3GHG 3H32 3HUS	1DUG 1FIB 1FIC 1FID 1FZA 1FZB 1FZC 1FZE 1FZF 1FZG 1LT9 1LTJ 1N86 1N8E 1RE3 1RE4 1RF0 1RF1 2A45 2FFD 2FIB 2H43 2HLO 2HOD 2HPC 2HWL 2OYH 2OYI 2Q9I 2VDO 2VDP 2VDQ 2VDR 2VR3 2XNX 2XNY 2Y7L 2Z4E 3BVH 3E1I 3FIB 3GHG 3H32 3HUS
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Cell-substrate Adhesion Regulation Of Substrate Adhesion-dependent Cell Spreading Response To Metal Ion Regulation Of Protein Metabolic Process Cellular Macromolecular Complex Assembly Hemostasis Regulation Of Cell-substrate Adhesion Response To Inorganic Substance Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Positive Regulation Of Heterotypic Cell-cell Adhesion Regulation Of Body Fluid Levels Cellular Protein Complex Assembly Response To Calcium Ion Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Cell Adhesion Cellular Component Assembly Regulation Of Phosphorylation Negative Regulation Of Cellular Protein Metabolic Process Blood Coagulation Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Phosphorylation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Metabolic Process Cell-matrix Adhesion Cellular Senescence Regulation Of Phosphorus Metabolic Process Regulation Of Cell Morphogenesis Positive Regulation Of Vasoconstriction Response To Hormone Regulation Of Endothelial Cell Apoptotic Process Platelet Aggregation Regulation Of Catalytic Activity Protein Complex Assembly Cell-substrate Adhesion Wound Healing Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Adhesion Regulation Of Vasoconstriction Negative Regulation Of Blood Coagulation, Common Pathway Blood Coagulation, Common Pathway Peptide Antigen Assembly With MHC Class I Protein Complex Fetal Process Involved In Parturition Positive Regulation Of Protein Metabolic Process Positive Regulation Of Exocytosis	Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Extracellular Matrix Organization Extracellular Structure Organization Response To Stress Platelet Degranulation Cell Activation Homotypic Cell-cell Adhesion Negative Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Vasoconstriction Regulation Of Endothelial Cell Apoptotic Process Platelet Aggregation Cell-matrix Adhesion Platelet Activation Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Single Organismal Cell-cell Adhesion Cell-substrate Adhesion Regulation Of Vasoconstriction Cell Adhesion Positive Regulation Of Heterotypic Cell-cell Adhesion Exocytosis Innate Immune Response Cell Adhesion Mediated By Integrin Positive Regulation Of Phosphorylation Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To Stimulus Positive Regulation Of Peptidyl-tyrosine Phosphorylation Secretion By Cell Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of ERK1 And ERK2 Cascade Regulation Of Cell-substrate Adhesion Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Signal Transduction Regulation Of Cell Adhesion Immune System Process Secretion Immune Response Leukocyte Migration Regulation Of Phosphorylation Defense Response
Tagcloud ?		assigned correlations decreasing delta deltafbg deltahoma diagnosed dipeptidyl dpp effectively efficacies fasting glycemic hba1c homa homeostasis hypoglycemic japanese monotherapy naive newly noted peptidase reductions safely t2dm teneligliptin ua uric	apo appeared approximately chain comparative conduct de differentially disappear exist expressions fibrinogen fragmented full h4 heavy inter iti iv kda lc matched pd people proteomic size spots trypsin validate
Tagcloud (Difference) ?		assigned correlations decreasing delta deltafbg deltahoma diagnosed dipeptidyl dpp effectively efficacies fasting glycemic hba1c homa homeostasis hypoglycemic japanese monotherapy naive newly noted peptidase reductions safely t2dm teneligliptin ua uric	apo appeared approximately chain comparative conduct de differentially disappear exist expressions fibrinogen fragmented full h4 heavy inter iti iv kda lc matched pd people proteomic size spots trypsin validate
Tagcloud (Intersection) ?