FGB and LPA

Number of citations of the paper that reports this interaction (PMID 10980194)
2

Data Source:
HPRD (in vivo, in vitro)

		FGB	LPA
Gene Name		fibrinogen beta chain	lipoprotein, Lp(a)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Fibrinogen Complex Extracellular Space Plasma Membrane Cell Cortex External Side Of Plasma Membrane Cell Surface Platelet Alpha Granule Platelet Alpha Granule Lumen Vesicle Extracellular Vesicular Exosome Blood Microparticle	Extracellular Region Plasma Lipoprotein Particle
	Molecular Function	Receptor Binding Structural Molecule Activity Protein Binding Protein Binding, Bridging Cell Adhesion Molecule Binding Chaperone Binding	Fibronectin Binding Serine-type Endopeptidase Activity Endopeptidase Inhibitor Activity Protein Binding Heparin Binding Apolipoprotein Binding
	Biological Process	Platelet Degranulation Cell-matrix Adhesion Signal Transduction Blood Coagulation Platelet Activation Extracellular Matrix Organization Positive Regulation Of Heterotypic Cell-cell Adhesion Cellular Protein Complex Assembly Cellular Response To Leptin Stimulus Innate Immune Response Positive Regulation Of Vasoconstriction Positive Regulation Of Exocytosis Positive Regulation Of Protein Secretion Protein Polymerization Response To Calcium Ion Positive Regulation Of ERK1 And ERK2 Cascade Platelet Aggregation Cellular Response To Interleukin-1 Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Endothelial Cell Apoptotic Process	Proteolysis Lipid Metabolic Process Lipid Transport Receptor-mediated Endocytosis Blood Circulation Negative Regulation Of Endopeptidase Activity Lipoprotein Metabolic Process Small Molecule Metabolic Process
Pathways		p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling GRB2:SOS provides linkage to MAPK signaling for Integrins Platelet degranulation Platelet Aggregation (Plug Formation) Formation of Fibrin Clot (Clotting Cascade) Common Pathway Response to elevated platelet cytosolic Ca2+ Integrin cell surface interactions Platelet activation, signaling and aggregation
Drugs			Aminocaproic Acid
Diseases
GWAS		Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Fibrinogen ( 20031576 20031577 21757653)	Aortic-valve calcification ( 23388002) Cholesterol, total ( 20686565) Coronary heart disease ( 19198611 21378990) HDL cholesterol ( 20686565) LDL cholesterol ( 20686565) Lipoprotein-associated phospholipase A2 activity change in response to statin therapy ( 23118302) Lp (a) levels ( 21900290 19124843) Monocyte early outgrowth colony forming units ( 21493818) Protein quantitative trait loci ( 18464913) Response to statin therapy ( 22368281) Response to statin therapy (LDL-C) ( 22331829)
Protein-Protein Interactions		15 interactors: AIMP2 ANXA7 CALR CDKN1A CSNK2B FBLN1 FGA FGG GRB7 LPA NID1 PIK3R3 SERPINA5 SMN1 TK1	9 interactors: APOH CANX CELA1 ELANE FBLN5 FGB FN1 LRP2 MMP12
Entrez ID		2244	4018
HPRD ID		00620	01063
Ensembl ID			ENSG00000198670
Uniprot IDs		P02675
PDB IDs		1FZA 1FZB 1FZC 1FZE 1FZF 1FZG 1LT9 1LTJ 1N86 1N8E 1RE3 1RE4 1RF0 1RF1 2A45 2FFD 2H43 2HLO 2HOD 2HPC 2OYH 2OYI 2Q9I 2XNX 2XNY 2Z4E 3BVH 3E1I 3GHG 3H32 3HUS
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Cell-substrate Adhesion Regulation Of Substrate Adhesion-dependent Cell Spreading Response To Metal Ion Regulation Of Protein Metabolic Process Cellular Macromolecular Complex Assembly Hemostasis Regulation Of Cell-substrate Adhesion Response To Inorganic Substance Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Positive Regulation Of Heterotypic Cell-cell Adhesion Regulation Of Body Fluid Levels Cellular Protein Complex Assembly Response To Calcium Ion Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Cell Adhesion Cellular Component Assembly Regulation Of Phosphorylation Negative Regulation Of Cellular Protein Metabolic Process Blood Coagulation Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Phosphorylation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Metabolic Process Cell-matrix Adhesion Cellular Senescence Regulation Of Phosphorus Metabolic Process Regulation Of Cell Morphogenesis Positive Regulation Of Vasoconstriction Response To Hormone Regulation Of Endothelial Cell Apoptotic Process Platelet Aggregation Regulation Of Catalytic Activity Protein Complex Assembly Cell-substrate Adhesion Wound Healing Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Adhesion Regulation Of Vasoconstriction Negative Regulation Of Blood Coagulation, Common Pathway Blood Coagulation, Common Pathway Peptide Antigen Assembly With MHC Class I Protein Complex Fetal Process Involved In Parturition Positive Regulation Of Protein Metabolic Process Positive Regulation Of Exocytosis	Extracellular Matrix Organization Extracellular Structure Organization Wound Healing Response To Wounding Extracellular Matrix Disassembly Blood Coagulation Hemostasis Cell-matrix Adhesion Response To Stress Regulation Of Body Fluid Levels Secretion Cell-substrate Adhesion Vesicle-mediated Transport Collagen Catabolic Process Platelet Degranulation Acute Inflammatory Response Collagen Metabolic Process Transport Multicellular Organismal Macromolecule Metabolic Process Inflammatory Response Multicellular Organismal Metabolic Process Secretion By Cell Neutrophil Mediated Killing Of Fungus Protein Metabolic Process Defense Response Triglyceride Transport Response To Stimulus Regulation Of Growth Regulation Of Cell Proliferation Calcium-independent Cell-matrix Adhesion Endocytosis Positive Regulation Of Cell Morphogenesis Involved In Differentiation Pancreas Morphogenesis Negative Regulation Of Chemokine Biosynthetic Process Negative Regulation Of Interleukin-8 Biosynthetic Process Response To Yeast Platelet Activation Elastic Fiber Assembly Negative Regulation Of Smooth Muscle Cell Apoptotic Process Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Positive Regulation Of Interleukin-8 Biosynthetic Process Killing By Host Of Symbiont Cells Cell Migration Leukocyte Migration Plasminogen Activation Acute Inflammatory Response To Antigenic Stimulus Exocrine Pancreas Development Negative Regulation Of Locomotion Positive Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of Fibrinolysis
Tagcloud ?		assigned correlations decreasing delta deltafbg deltahoma diagnosed dipeptidyl dpp effectively efficacies fasting glycemic hba1c homa homeostasis hypoglycemic japanese monotherapy naive newly noted peptidase reductions safely t2dm teneligliptin ua uric	adequacy amplified apl attributable cdna concordance disagreement ensure external hematological hospitals implementation inadequacy laboratories malignancies participating pethema pml promyelocytic rearrangements rr satisfactorily scheme sent spanish standardization standardize stressed supporting
Tagcloud (Difference) ?		assigned correlations decreasing delta deltafbg deltahoma diagnosed dipeptidyl dpp effectively efficacies fasting glycemic hba1c homa homeostasis hypoglycemic japanese monotherapy naive newly noted peptidase reductions safely t2dm teneligliptin ua uric	adequacy amplified apl attributable cdna concordance disagreement ensure external hematological hospitals implementation inadequacy laboratories malignancies participating pethema pml promyelocytic rearrangements rr satisfactorily scheme sent spanish standardization standardize stressed supporting
Tagcloud (Intersection) ?