FGB and LPA

Number of citations of the paper that reports this interaction (PubMedID 10980194)
0

Data Source:
HPRD (in vitro, in vivo)

		FGB	LPA
Description		fibrinogen beta chain	lipoprotein(a)
Image
GO Annotations	Cellular Component	Extracellular Region Fibrinogen Complex Extracellular Space Endoplasmic Reticulum Plasma Membrane Cell Cortex External Side Of Plasma Membrane Cell Surface Extracellular Matrix Platelet Alpha Granule Platelet Alpha Granule Lumen Synapse Extracellular Exosome Blood Microparticle Extracellular Vesicle	Extracellular Region Plasma Lipoprotein Particle
	Molecular Function	Signaling Receptor Binding Structural Molecule Activity Extracellular Matrix Structural Constituent Protein Binding Cell Adhesion Molecule Binding Protein-folding Chaperone Binding	Fibronectin Binding Serine-type Endopeptidase Activity Endopeptidase Inhibitor Activity Protein Binding Heparin Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Apolipoprotein Binding
	Biological Process	Adaptive Immune Response Immune System Process Cell-matrix Adhesion Blood Coagulation Hemostasis Platelet Activation Plasminogen Activation Positive Regulation Of Heterotypic Cell-cell Adhesion Fibrinolysis Induction Of Bacterial Agglutination Cellular Response To Leptin Stimulus Innate Immune Response Positive Regulation Of Vasoconstriction Positive Regulation Of Exocytosis Positive Regulation Of Protein Secretion Protein Polymerization Response To Calcium Ion Protein-containing Complex Assembly Positive Regulation Of ERK1 And ERK2 Cascade Platelet Aggregation Cellular Response To Interleukin-1 Blood Coagulation, Fibrin Clot Formation Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Endothelial Cell Apoptotic Process	Proteolysis Lipid Metabolic Process Lipid Transport Blood Circulation
Pathways		Platelet degranulation ER-Phagosome pathway Common Pathway of Fibrin Clot Formation MyD88:MAL(TIRAP) cascade initiated on plasma membrane Integrin cell surface interactions Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) MAP2K and MAPK activation Regulation of TLR by endogenous ligand Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants	LDL remodeling
Drugs		Sucralfate Alfimeprase Thrombin Prothrombin Human thrombin Thrombin alfa Anti-inhibitor coagulant complex	Aminocaproic acid
Diseases		Inherited thrombophilia Afibrinogenemia; Dysfibrinogenemia
GWAS		Chronic obstructive pulmonary disease-related biomarkers ( 23144326) D-dimer levels in HIV infection ( 33095540) Fibrinogen ( 20031576 20031577 21757653 23969696) Fibrinogen levels ( 26561523 28107422 29403010)	A body shape index ( 34021172) Abdominal aortic aneurysm ( 32981348) Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Aortic valve stenosis ( 29511194) Aortic-valve calcification ( 23388002) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) C-reactive protein levels ( 33339817) Calcific aortic valve stenosis ( 32141789) Cholesterol, total ( 20686565 24097068 25961943 28270201) Coronary artery disease ( 24262325 26343387 28714974 29212778 32469254 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease in diabetes ( 30003307) Coronary artery disease or ischemic stroke ( 24262325) Coronary artery disease or large artery stroke ( 24262325) Coronary heart disease ( 19198611 21378990) End stage renal disease x APOL1 genotype interaction ( 29885931) HDL cholesterol ( 20686565 25961943) HDL cholesterol levels ( 32203549) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heart failure ( 31919418) High density lipoprotein cholesterol levels ( 33339817) Hip circumference adjusted for BMI ( 34021172) LDL cholesterol ( 20686565 24097068 25961943 30275531) LDL cholesterol levels ( 32203549) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Lipid or lipoprotein levels ( 23696881) Lipoprotein (a) levels ( 26377243 28512139 30108283 33115273 33730874) Lipoprotein (a) levels in coronary artery disease (percutaneous coronary intervention) ( 31186284) Lipoprotein (a) levels in response to niacin in statin-treated individuals ( 30371334) Lipoprotein phospholipase A2 activity in cardiovascular disease ( 28753643) Lipoprotein(a) levels adjusted for apolipoprotein(a) isoforms ( 28512139) Lipoprotein-associated phospholipase A2 activity change in response to statin therapy ( 23118302) Low density lipoprotein cholesterol levels ( 32154731 33339817) Lp (a) levels ( 19124843 21900290) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (antithrombotic agents) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Medication use (salicylic acid and derivatives) ( 31015401) Medication use (vasodilators used in cardiac diseases) ( 31015401) Metabolic syndrome ( 31589552) Minimum ankle–brachial index ( 31285632) Monocyte early outgrowth colony forming units ( 21493818) Myocardial infarction ( 26343387 33532862) Parental lifespan ( 29030599 30642433) Parental longevity (both parents in top 10%) ( 29227965) Parental longevity (combined parental age at death) ( 29227965) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (father's age at death) ( 29227965 31484785) Parental longevity (father's attained age) ( 29227965) Parental longevity (mother's age at death or mother's attained age) ( 31484785) Parental longevity (mother's age at death) ( 29227965) Parental longevity (mother's attained age) ( 29227965) Peripheral artery disease ( 31285632) Plasma plasminogen levels ( 25208887) Plateletcrit ( 32888494) Protein quantitative trait loci ( 18464913) Response to statin therapy ( 22368281) Response to statins (LDL cholesterol change) ( 22331829 25350695) Total cholesterol levels ( 28334899 30275531 33339817) Triglyceride levels ( 32154731 32203549) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 25961943 30275531) Urinary albumin excretion ( 32277301) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		19 interacting genes: AIMP2 ANXA7 APP CALR CDKN1A CSNK2B FBLN1 FGA FGG GRB7 LPA NID1 PIK3R3 RNF181 SERPINA5 SMN1 TK1 UFL1 VWF	9 interacting genes: APOH CANX CELA1 ELANE FBLN5 FGB FN1 LRP2 MMP12
Entrez ID		2244	4018
HPRD ID		00620	01063
Ensembl ID		ENSG00000171564	ENSG00000198670
Uniprot IDs		P02675 V9HVY1	P08519
PDB IDs		1FZA 1FZB 1FZC 1FZE 1FZF 1FZG 1LT9 1LTJ 1N86 1N8E 1RE3 1RE4 1RF0 1RF1 2A45 2FFD 2H43 2HLO 2HOD 2HPC 2OYH 2OYI 2Q9I 2XNX 2XNY 2Z4E 3BVH 3E1I 3GHG 3H32 3HUS 6ATZ 6BIJ 6BIL 6V0Y 6V13 6V15 6V18 6V19 6V1A	1I71 1JFN 1KIV 2FEB 3KIV 4BV5 4BV7 4BVC 4BVD 4BVV 4BVW 4KIV 6RX7 8TCE 8V8Z 8V9B
Enriched GO Terms of Interacting Partners?		Platelet Alpha Granule Blood Coagulation, Fibrin Clot Formation Extracellular Matrix Structural Constituent Extracellular Matrix Positive Regulation Of Cell-substrate Adhesion Integrin Binding Regulation Of Substrate Adhesion-dependent Cell Spreading Platelet Alpha Granule Lumen Protein Activation Cascade Negative Regulation Of Protein Metabolic Process Protein-containing Complex Assembly Regulation Of Cell-substrate Adhesion Protein-containing Complex Organization Regulation Of Protein Metabolic Process Positive Regulation Of Cell Adhesion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Extracellular Exosome Response To Metal Ion Extracellular Region Cell-substrate Adhesion External Side Of Plasma Membrane Fibrinogen Complex Peptidase Activator Activity Platelet Activation Plasminogen Activation Cellular Component Assembly Positive Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of Gene Expression Apolipoprotein Binding Regulation Of Cell Adhesion Protein-folding Chaperone Binding Cell-matrix Adhesion Fibrinolysis Coagulation Blood Coagulation Hemostasis Regulation Of ERK1 And ERK2 Cascade Endoplasmic Reticulum Lumen Positive Regulation Of Cell Migration Protein Serine/threonine Kinase Binding Positive Regulation Of Cell Motility Molecular Function Activator Activity Protein Maturation Circulatory System Process Positive Regulation Of Locomotion Protein Metabolic Process Response To Calcium Ion Positive Regulation Of Vasoconstriction Regulation Of Cell Migration Fibronectin Binding	Protein Activation Cascade Extracellular Space Elastin Catabolic Process Extracellular Matrix Positive Regulation Of Multicellular Organismal Process Regulation Of Cell Population Proliferation Elastin Metabolic Process Regulation Of Multicellular Organismal Process Proteolysis Fibrinogen Complex Blood Coagulation, Fibrin Clot Formation Extracellular Exosome Extracellular Region Plasminogen Activation Cell-matrix Adhesion Response To Leptin Positive Regulation Of Cell Population Proliferation Serine-type Endopeptidase Activity Heparin Binding Cell-substrate Adhesion Protein Metabolic Process Glycoprotein Catabolic Process Negative Regulation Of Multicellular Organismal Process Zymogen Activation Calcium Ion Binding Biological Process Involved In Interaction With Symbiont Regulation Of Cell-substrate Adhesion Protein Catabolic Process Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Blood Coagulation Macromolecule Metabolic Process Extracellular Matrix Disassembly Negative Regulation Of Hemostasis Positive Regulation Of Metabolic Process Negative Regulation Of Coagulation Regulation Of Multicellular Organismal Development Protein Maturation Regulation Of Angiogenesis Biosynthetic Process Of Antibacterial Peptides Active Against Gram-negative Bacteria Regulation Of Cell Adhesion Acute Inflammatory Response Platelet Alpha Granule Lumen Collagen Binding Intramembranous Bone Growth Regulation Of Vasculature Development Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Anatomical Structure Morphogenesis
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