FGB and RNF181

Number of citations of the paper that reports this interaction (PubMedID 26398855)
0

Data Source:
BioGRID (two hybrid)

		FGB	RNF181
Description		fibrinogen beta chain	ring finger protein 181
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Fibrinogen Complex Extracellular Space Endoplasmic Reticulum Plasma Membrane Cell Cortex External Side Of Plasma Membrane Cell Surface Extracellular Matrix Platelet Alpha Granule Platelet Alpha Granule Lumen Synapse Extracellular Exosome Blood Microparticle Extracellular Vesicle	Cytoplasm
	Molecular Function	Signaling Receptor Binding Structural Molecule Activity Extracellular Matrix Structural Constituent Protein Binding Cell Adhesion Molecule Binding Protein-folding Chaperone Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Adaptive Immune Response Immune System Process Cell-matrix Adhesion Blood Coagulation Hemostasis Platelet Activation Plasminogen Activation Positive Regulation Of Heterotypic Cell-cell Adhesion Fibrinolysis Induction Of Bacterial Agglutination Cellular Response To Leptin Stimulus Innate Immune Response Positive Regulation Of Vasoconstriction Positive Regulation Of Exocytosis Positive Regulation Of Protein Secretion Protein Polymerization Response To Calcium Ion Protein-containing Complex Assembly Positive Regulation Of ERK1 And ERK2 Cascade Platelet Aggregation Cellular Response To Interleukin-1 Blood Coagulation, Fibrin Clot Formation Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Endothelial Cell Apoptotic Process	Protein Ubiquitination Protein Autoubiquitination
Pathways		Platelet degranulation ER-Phagosome pathway Common Pathway of Fibrin Clot Formation MyD88:MAL(TIRAP) cascade initiated on plasma membrane Integrin cell surface interactions Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) MAP2K and MAPK activation Regulation of TLR by endogenous ligand Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants	E3 ubiquitin ligases ubiquitinate target proteins
Drugs		Sucralfate Alfimeprase Thrombin Prothrombin Human thrombin Thrombin alfa Anti-inhibitor coagulant complex
Diseases		Inherited thrombophilia Afibrinogenemia; Dysfibrinogenemia
GWAS		Chronic obstructive pulmonary disease-related biomarkers ( 23144326) D-dimer levels in HIV infection ( 33095540) Fibrinogen ( 20031576 20031577 21757653 23969696) Fibrinogen levels ( 26561523 28107422 29403010)	Prostate cancer ( 21743467)
Interacting Genes		19 interacting genes: AIMP2 ANXA7 APP CALR CDKN1A CSNK2B FBLN1 FGA FGG GRB7 LPA NID1 PIK3R3 RNF181 SERPINA5 SMN1 TK1 UFL1 VWF	32 interacting genes: ALB BCL10 BIRC2 BTG1 CARD11 CLK4 ELL2 FGB HBA1 MCM7 MRPS6 MT1E MT1H NDUFB10 NPY5R PEG10 RBCK1 RPL5 SFMBT2 TRIM24 TRIM8 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2N UBE2U VPS11 ZMYND10
Entrez ID		2244	51255
HPRD ID		00620	14236
Ensembl ID		ENSG00000171564	ENSG00000168894
Uniprot IDs		P02675 V9HVY1	Q9P0P0
PDB IDs		1FZA 1FZB 1FZC 1FZE 1FZF 1FZG 1LT9 1LTJ 1N86 1N8E 1RE3 1RE4 1RF0 1RF1 2A45 2FFD 2H43 2HLO 2HOD 2HPC 2OYH 2OYI 2Q9I 2XNX 2XNY 2Z4E 3BVH 3E1I 3GHG 3H32 3HUS 6ATZ 6BIJ 6BIL 6V0Y 6V13 6V15 6V18 6V19 6V1A
Enriched GO Terms of Interacting Partners?		Platelet Alpha Granule Blood Coagulation, Fibrin Clot Formation Extracellular Matrix Structural Constituent Extracellular Matrix Positive Regulation Of Cell-substrate Adhesion Integrin Binding Regulation Of Substrate Adhesion-dependent Cell Spreading Platelet Alpha Granule Lumen Protein Activation Cascade Negative Regulation Of Protein Metabolic Process Protein-containing Complex Assembly Regulation Of Cell-substrate Adhesion Protein-containing Complex Organization Regulation Of Protein Metabolic Process Positive Regulation Of Cell Adhesion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Extracellular Exosome Response To Metal Ion Extracellular Region Cell-substrate Adhesion External Side Of Plasma Membrane Fibrinogen Complex Peptidase Activator Activity Platelet Activation Plasminogen Activation Cellular Component Assembly Positive Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of Gene Expression Apolipoprotein Binding Regulation Of Cell Adhesion Protein-folding Chaperone Binding Cell-matrix Adhesion Fibrinolysis Coagulation Blood Coagulation Hemostasis Regulation Of ERK1 And ERK2 Cascade Endoplasmic Reticulum Lumen Positive Regulation Of Cell Migration Protein Serine/threonine Kinase Binding Positive Regulation Of Cell Motility Molecular Function Activator Activity Protein Maturation Circulatory System Process Positive Regulation Of Locomotion Protein Metabolic Process Response To Calcium Ion Positive Regulation Of Vasoconstriction Regulation Of Cell Migration Fibronectin Binding	Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Post-translational Protein Modification Protein K48-linked Ubiquitination Modification-dependent Protein Catabolic Process Ubiquitin Protein Ligase Activity Proteolysis Involved In Protein Catabolic Process Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein Metabolic Process Protein Monoubiquitination Positive Regulation Of Protein Polyubiquitination Proteolysis Transferase Activity Protein K63-linked Ubiquitination Positive Regulation Of NF-kappaB Transcription Factor Activity Catabolic Process Regulation Of Protein Polyubiquitination Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Protein Ubiquitination CBM Complex Positive Regulation Of Protein Ubiquitination Protein K11-linked Ubiquitination Positive Regulation Of DNA-binding Transcription Factor Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Post-translational Protein Modification Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Post-translational Protein Modification Protein Catabolic Process Regulation Of Intracellular Signal Transduction ATP Binding Transcription Coactivator Activity Canonical NF-kappaB Signal Transduction Nucleotide Binding Macromolecule Metabolic Process Proteasomal Protein Catabolic Process TORC1 Signaling Detoxification Of Copper Ion Nucleus Regulation Of Protein K63-linked Ubiquitination CARD Domain Binding Regulation Of DNA-binding Transcription Factor Activity Protein-containing Complex TOR Signaling Regulation Of Signal Transduction
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