FDX1 and CORO2A

Data Source: HiPPIP (Novel)

		FDX1	CORO2A
Name		ferredoxin 1	coronin 2A
Structure			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Brush Border Transcription Repressor Complex
	Molecular Function	Iron Ion Binding Electron Transfer Activity Metal Ion Binding Iron-sulfur Cluster Binding 2 Iron, 2 Sulfur Cluster Binding	Actin Binding Protein Binding Actin Filament Binding
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Steroid Metabolic Process Cholesterol Metabolic Process Electron Transport Chain Hormone Biosynthetic Process Cellular Response To CAMP P450-containing Electron Transport Chain Cellular Response To Forskolin	Intracellular Signal Transduction
Pathways		Mitochondrial iron-sulfur cluster biogenesis Pregnenolone biosynthesis Endogenous sterols Electron transport from NADPH to Ferredoxin Defective CYP11A1 causes AICSR Protein lipoylation	None
Drugs		Mitotane	None
GWAS		Cognitive function ( 24684796 ) Coronary artery disease ( 32469254 ) Serum metabolite levels ( 33031748 )	Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912 ) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962 )
Interacting Genes		5 interacting genes: CYCS CYP11A1 CYP11B2 FDXR PRKAB2	12 interacting genes: AURKA BUB1 DCC DLC1 HDAC3 NRAS RB1 RSPH1 SMAD2 TBL1X TBL1XR1 UBE2I
Entrez ID		2230	7464
HPRD ID		00059	03695
Ensembl ID		ENSG00000137714	ENSG00000106789
Uniprot IDs		P10109	A8K9S3 Q92828
PDB IDs		3N9Y 3N9Z 3NA0 3NA1 3P1M 7M8I	Not available
GO Terms Enriched among Interactors		C21-steroid Hormone Biosynthetic Process Steroid Metabolic Process Glucocorticoid Biosynthetic Process Steroid Biosynthetic Process Cortisol Metabolic Process Ketone Metabolic Process Alcohol Metabolic Process Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Steroid Hydroxylase Activity Glucocorticoid Metabolic Process Regulation Of RIG-I Signaling Pathway Negative Regulation Of Necroptotic Process Cholesterol Metabolic Process Heme Binding Sterol Metabolic Process Negative Regulation Of Programmed Necrotic Cell Death Olefinic Compound Metabolic Process C21-steroid Hormone Metabolic Process Mitochondrial Inner Membrane Steroid Hormone Biosynthetic Process Regulation Of Necroptotic Process Non-canonical NF-kappaB Signal Transduction Ketone Biosynthetic Process Hormone Metabolic Process Regulation Of Programmed Necrotic Cell Death Hormone Biosynthetic Process Regulation Of Toll-like Receptor Signaling Pathway Lipid Biosynthetic Process Oxidoreductase Activity Lipid Metabolic Process Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Iron-sulfur Protein As One Donor, And Incorporation Of One Atom Of Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Cholesterol Monooxygenase (side-chain-cleaving) Activity Ferredoxin-NADP+ Reductase Activity 11-cis-retinol Dehydrogenase (NAD+) Activity Canonical NF-kappaB Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Monooxygenase Activity FBXO Family Protein Binding Steroid 11-beta-monooxygenase Activity Regulation Of Blood Volume By Renal Aldosterone Corticosterone 18-monooxygenase Activity Negative Regulation Of Postsynaptic Density Organization MHC Class Ib Protein Complex Binding Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein-containing Complex Binding Small Molecule Metabolic Process Positive Regulation Of Protein K48-linked Ubiquitination	Mitotic Spindle Histone Deacetylase Complex Transcription Corepressor Activity Transcription Repressor Complex Meiotic Spindle Regulation Of Mitotic Nuclear Division Regulation Of Nuclear Division Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of DNA-templated Transcription Disordered Domain Specific Binding Negative Regulation Of RNA Biosynthetic Process Cell Division Chromatin Organization Aortic Valve Morphogenesis Negative Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Binding Regulation Of Mitotic Cell Cycle Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Signal Transduction Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Histone H2A Kinase Activity Negative Regulation Of Biosynthetic Process Positive Regulation Of Mitotic Nuclear Division Regulation Of Epithelial Cell Apoptotic Process Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process SUMO Conjugating Enzyme Activity Positive Regulation Of Ferroptosis Heart Valve Morphogenesis Membrane Assembly Positive Regulation Of Cell Cycle Process Regulation Of Mitotic Sister Chromatid Separation Cytosol Chromatin Remodeling Negative Regulation Of Macromolecule Metabolic Process Regulation Of Chromosome Separation Negative Regulation Of Cell Differentiation P450-containing Electron Transport Chain Homomeric SMAD Protein Complex Ubiquitin Protein Ligase Binding Axis Specification Proteolysis Involved In Protein Catabolic Process Protein De-2-hydroxyisobutyrylase Activity Hindbrain Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Ras Protein Signal Transduction Positive Regulation Of Cell Cycle