TSPO2 and SYT2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TSPO2	SYT2
Description		translocator protein 2	synaptotagmin 2
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Organelle Membrane	Cytoplasm Plasma Membrane Membrane Axon Clathrin-coated Endocytic Vesicle Membrane Synaptic Vesicle Membrane Dense Core Granule Cytoplasmic Vesicle Chromaffin Granule Membrane Synapse Exocytic Vesicle
	Molecular Function	Protein Binding Cholesterol Binding 5-aminolevulinic Acid Transmembrane Transporter Activity	SNARE Binding Protein Binding Calcium-dependent Phospholipid Binding Inositol 1,3,4,5 Tetrakisphosphate Binding Metal Ion Binding Calcium Ion Sensor Activity
	Biological Process	Intracellular Cholesterol Transport Lipid Droplet Organization Enucleate Erythrocyte Differentiation Import Across Plasma Membrane 5-aminolevulinic Acid Import Across Plasma Membrane	Vesicle-mediated Transport Regulation Of Calcium Ion-dependent Exocytosis Cell Differentiation Calcium-dependent Activation Of Synaptic Vesicle Fusion Positive Regulation Of Dendrite Extension Regulation Of Synaptic Vesicle Exocytosis
Pathways			Toxicity of botulinum toxin type B (botB) Neurexins and neuroligins Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs			Botulinum toxin type B
Diseases
GWAS		Gastric cancer ( 26129866) Non-cardia gastric cancer ( 26129866)	Celiac disease ( 23936387) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383)
Interacting Genes		62 interacting genes: AHNAK2 AQP6 ARL13B ASGR2 ASZ1 BIK CD53 CD69 CD79A CERS4 CLDN4 CNR2 COL4A5 CPLX4 CREB3L1 DKK4 EBP EFNA5 EMP1 ERGIC3 ERP29 FCER1G FCGR1A FFAR2 FKBP7 FNDC9 FXYD3 GGT7 GJB5 GPR152 GPR42 GPX8 IGFBP5 KCNJ6 KLRC1 LRRC59 MAL MARCHF2 MFF MFSD6 MS4A1 PDZK1IP1 PLEKHO1 PSCA RELL2 RETREG3 RPRM SLC10A1 SLC10A6 SLC16A2 SLC18A1 SLC34A2 SLC35H1 SLC41A3 SLC7A1 SPAG4 STOM SYT2 TMEM140 TMEM54 TMEM80 VSIR	29 interacting genes: AQP10 BNIP2 CCDC167 CLDN4 CMTM3 FA2H FUNDC2 ITGAM KLHL3 LAT MALL MIP NAPB NRXN1 ORMDL3 PLPP4 PMP22 SLC30A8 SLC35A1 SLC35A4 STON2 SYNCRIP TF THSD7B TMEM107 TMEM229B TSPO2 VAMP4 WNK1
Entrez ID		222642	127833
HPRD ID		16569	02520
Ensembl ID		ENSG00000112212	ENSG00000143858
Uniprot IDs		Q5TGU0	Q8N9I0
PDB IDs			6G5G
Enriched GO Terms of Interacting Partners?		Membrane Plasma Membrane Protein Binding Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I External Side Of Plasma Membrane Positive Regulation Of Type III Hypersensitivity Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Type IIa Hypersensitivity Positive Regulation Of Acute Inflammatory Response Bile Acid:sodium Symporter Activity Transmembrane Transport Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Hypersensitivity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Antigen Processing And Presentation Of Exogenous Peptide Antigen Sodium Ion Transport Regulation Of Acute Inflammatory Response Antigen Processing And Presentation Of Exogenous Antigen Immune Response-regulating Signaling Pathway Serotonin Transport	Membrane Pyrimidine Nucleotide-sugar Transmembrane Transporter Activity Transmembrane Transport Pyrimidine Nucleotide-sugar Transmembrane Transport Nucleotide-sugar Transmembrane Transport Homeostatic Process Endocytic Vesicle Water Channel Activity Chemical Homeostasis
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