TSPO2 and CERS4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TSPO2	CERS4
Description		translocator protein 2	ceramide synthase 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Organelle Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding Cholesterol Binding 5-aminolevulinic Acid Transmembrane Transporter Activity	DNA Binding Protein Binding Transferase Activity Sphingosine N-acyltransferase Activity
	Biological Process	Intracellular Cholesterol Transport Lipid Droplet Organization Enucleate Erythrocyte Differentiation Import Across Plasma Membrane 5-aminolevulinic Acid Import Across Plasma Membrane	Lipid Metabolic Process Sphingolipid Metabolic Process Sphingolipid Biosynthetic Process Ceramide Biosynthetic Process
Pathways			Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Gastric cancer ( 26129866) Non-cardia gastric cancer ( 26129866)	Macular telangiectasia type 2 ( 33654266) Mean reticulocyte volume ( 32888494) Metabolite levels ( 31628463) Red cell distribution width ( 32888494) Refractive error ( 32231278) Serum metabolite levels ( 33031748) Serum metabolite ratios in chronic kidney disease ( 29545352) Sphingomyelin levels ( 31551469) Thyroid stimulating hormone levels ( 30367059 32769997) Very long-chain saturated fatty acid levels (fatty acid 24:0) ( 25378659)
Interacting Genes		62 interacting genes: AHNAK2 AQP6 ARL13B ASGR2 ASZ1 BIK CD53 CD69 CD79A CERS4 CLDN4 CNR2 COL4A5 CPLX4 CREB3L1 DKK4 EBP EFNA5 EMP1 ERGIC3 ERP29 FCER1G FCGR1A FFAR2 FKBP7 FNDC9 FXYD3 GGT7 GJB5 GPR152 GPR42 GPX8 IGFBP5 KCNJ6 KLRC1 LRRC59 MAL MARCHF2 MFF MFSD6 MS4A1 PDZK1IP1 PLEKHO1 PSCA RELL2 RETREG3 RPRM SLC10A1 SLC10A6 SLC16A2 SLC18A1 SLC34A2 SLC35H1 SLC41A3 SLC7A1 SPAG4 STOM SYT2 TMEM140 TMEM54 TMEM80 VSIR	47 interacting genes: - C1QL4 CCL4L2 CLEC1A COL4A5 CTXN3 CXCL16 CYB5R3 EMD FATE1 FCER1G FXYD6 FXYD6-FXYD2 GPR151 IER3IP1 IGFBP5 ITGAM JAGN1 LHFPL5 MS4A1 NAT8 NEU1 PLP2 PNLIPRP1 PTPN9 SCAMP5 SCD SERF1A SERF1B SERP2 SLC13A4 SLC29A2 SLC35A1 SLC35F6 SLC7A1 SMIM11 STX7 STX8 TEX264 TMEM119 TMEM176A TMEM254 TMEM72 TOMM6 TSPO2 UPK1B VAMP2
Entrez ID		222642	79603
HPRD ID		16569	13962
Ensembl ID		ENSG00000112212	ENSG00000090661
Uniprot IDs		Q5TGU0	Q53HF9 Q9HA82
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Plasma Membrane Protein Binding Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I External Side Of Plasma Membrane Positive Regulation Of Type III Hypersensitivity Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Type IIa Hypersensitivity Positive Regulation Of Acute Inflammatory Response Bile Acid:sodium Symporter Activity Transmembrane Transport Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Hypersensitivity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Antigen Processing And Presentation Of Exogenous Peptide Antigen Sodium Ion Transport Regulation Of Acute Inflammatory Response Antigen Processing And Presentation Of Exogenous Antigen Immune Response-regulating Signaling Pathway Serotonin Transport	Membrane Amyloid Fibril Formation Endoplasmic Reticulum Membrane Endoplasmic Reticulum Regulation Of Exocytosis SNAP Receptor Activity Chloride Channel Inhibitor Activity Membrane Organization Positive Regulation Of Regulated Secretory Pathway SNARE Complex Syntaxin Binding Regulation Of Regulated Secretory Pathway Regulation Of Cellular Localization Regulation Of Protein Localization SNARE Binding
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