TSPO2 and CLDN4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TSPO2	CLDN4
Description		translocator protein 2	claudin 4
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Organelle Membrane	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Basal Plasma Membrane Membrane Apical Plasma Membrane Apicolateral Plasma Membrane Lateral Plasma Membrane Chloride Channel Complex Tight Junction Anchoring Junction
	Molecular Function	Protein Binding Cholesterol Binding 5-aminolevulinic Acid Transmembrane Transporter Activity	Transmembrane Signaling Receptor Activity Structural Molecule Activity Chloride Channel Activity Protein Binding Identical Protein Binding
	Biological Process	Intracellular Cholesterol Transport Lipid Droplet Organization Enucleate Erythrocyte Differentiation Import Across Plasma Membrane 5-aminolevulinic Acid Import Across Plasma Membrane	Monoatomic Ion Transport Chloride Transport Cell Adhesion Female Pregnancy Circadian Rhythm Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Regulation Of Cell Morphogenesis Positive Regulation Of Cell Migration Response To Progesterone Monoatomic Ion Transmembrane Transport Establishment Of Skin Barrier Renal Absorption Bicellular Tight Junction Assembly Positive Regulation Of Wound Healing Paracellular Transport Chloride Transmembrane Transport
Pathways			Tight junction interactions
Drugs
Diseases
GWAS		Gastric cancer ( 26129866) Non-cardia gastric cancer ( 26129866)
Interacting Genes		62 interacting genes: AHNAK2 AQP6 ARL13B ASGR2 ASZ1 BIK CD53 CD69 CD79A CERS4 CLDN4 CNR2 COL4A5 CPLX4 CREB3L1 DKK4 EBP EFNA5 EMP1 ERGIC3 ERP29 FCER1G FCGR1A FFAR2 FKBP7 FNDC9 FXYD3 GGT7 GJB5 GPR152 GPR42 GPX8 IGFBP5 KCNJ6 KLRC1 LRRC59 MAL MARCHF2 MFF MFSD6 MS4A1 PDZK1IP1 PLEKHO1 PSCA RELL2 RETREG3 RPRM SLC10A1 SLC10A6 SLC16A2 SLC18A1 SLC34A2 SLC35H1 SLC41A3 SLC7A1 SPAG4 STOM SYT2 TMEM140 TMEM54 TMEM80 VSIR	19 interacting genes: AQP6 ARL13B CLEC14A EPHA2 FAM209A FFAR2 GJA8 GOLM1 HSD17B13 ICAM3 SHBG SLC71A2 SYT2 TJP1 TMEM237 TMEM52B TRIM59 TSPO2 WNK4
Entrez ID		222642	1364
HPRD ID		16569	04218
Ensembl ID		ENSG00000112212	ENSG00000189143
Uniprot IDs		Q5TGU0	O14493 Q75L80
PDB IDs			5B2G 7KP4 7TDM 7TDN 8U4V 8U5B 9CMH 9CMI
Enriched GO Terms of Interacting Partners?		Membrane Plasma Membrane Protein Binding Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I External Side Of Plasma Membrane Positive Regulation Of Type III Hypersensitivity Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Type IIa Hypersensitivity Positive Regulation Of Acute Inflammatory Response Bile Acid:sodium Symporter Activity Transmembrane Transport Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Hypersensitivity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Antigen Processing And Presentation Of Exogenous Peptide Antigen Sodium Ion Transport Regulation Of Acute Inflammatory Response Antigen Processing And Presentation Of Exogenous Antigen Immune Response-regulating Signaling Pathway Serotonin Transport	Membrane
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