TSPO2 and EMP1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		TSPO2	EMP1
Name		translocator protein 2	epithelial membrane protein 1
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Organelle Membrane	Plasma Membrane Membrane
	Molecular Function	Protein Binding Cholesterol Binding 5-aminolevulinic Acid Transmembrane Transporter Activity	Protein Binding
	Biological Process	Intracellular Cholesterol Transport Lipid Droplet Organization Enucleate Erythrocyte Differentiation Import Across Plasma Membrane 5-aminolevulinic Acid Import Across Plasma Membrane	Apoptotic Process Epidermis Development Bleb Assembly
GWAS		Gastric cancer ( 26129866 ) Non-cardia gastric cancer ( 26129866 )	Coronary artery calcification ( 23870195 ) Degraded stimulus continuous performance test score ( 31596458 ) Estimated glomerular filtration rate after 1 year in renal transplantation (donor effect) ( 30920136 ) Heel bone mineral density ( 28869591 30598549 ) Household income (MTAG) ( 31844048 ) Refractive error ( 32231278 ) Serum albumin levels ( 29403010 )
Novel Interactors		1 novel interactors: RSPH9	2 novel interactors: C1QBP CD40
Interacting Genes		62 interacting genes: AHNAK2 AQP6 ARL13B ASGR2 ASZ1 BIK CD53 CD69 CD79A CERS4 CLDN4 CNR2 COL4A5 CPLX4 CREB3L1 DKK4 EBP EFNA5 EMP1 ERGIC3 ERP29 FCER1G FCGR1A FFAR2 FKBP7 FNDC9 FXYD3 GGT7 GJB5 GPR152 GPR42 GPX8 IGFBP5 KCNJ6 KLRC1 LRRC59 MAL MARCHF2 MFF MFSD6 MS4A1 PDZK1IP1 PLEKHO1 PSCA RELL2 RETREG3 RPRM SLC10A1 SLC10A6 SLC16A2 SLC18A1 SLC34A2 SLC35H1 SLC41A3 SLC7A1 SPAG4 STOM SYT2 TMEM140 TMEM54 TMEM80 VSIR	61 interacting genes: ANK1 ANKS6 APOL2 AQP6 ARL13B ARL6IP1 ASGR2 ATP6V0B ATP6V0E1 BTN2A2 CATSPERH CCR5 CD37 CD3G CD53 CD79A CEP70 CLDN9 CORIN CXCR2 EBP EDA EHHADH ERGIC3 FFAR2 GIMAP5 GPR42 GPRC5D HTR2C ISLR2 JPH1 KLRC1 LAPTM4B LEPROTL1 LHFPL5 LPAR6 LRRC3B LSMEM2 MAL MALL MS4A7 OPRM1 PLEKHB2 PMP22 RABAC1 RPRM SERTM1 SMIM3 SPACA1 STOM SYNE4 TBXA2R TEX264 TLCD4 TMEM114 TMEM160 TMEM218 TMEM239 TMEM31 TMEM9 TSPO2
Entrez ID		222642	2012
HPRD ID		16569	11892
Ensembl ID		ENSG00000112212	ENSG00000134531
Uniprot IDs		Q5TGU0	P54849
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Membrane Plasma Membrane Protein Binding Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I External Side Of Plasma Membrane Positive Regulation Of Type III Hypersensitivity Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Type IIa Hypersensitivity Positive Regulation Of Acute Inflammatory Response Bile Acid:sodium Symporter Activity Transmembrane Transport Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Hypersensitivity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Antigen Processing And Presentation Of Exogenous Peptide Antigen Sodium Ion Transport Regulation Of Acute Inflammatory Response Antigen Processing And Presentation Of Exogenous Antigen Immune Response-regulating Signaling Pathway Serotonin Transport	Membrane Plasma Membrane Protein Binding G Protein-coupled Receptor Activity External Side Of Plasma Membrane Immune Response-regulating Cell Surface Receptor Signaling Pathway Multivesicular Body Membrane