TSPO2 and DKK4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TSPO2	DKK4
Description		translocator protein 2	dickkopf Wnt signaling pathway inhibitor 4
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Organelle Membrane	Extracellular Region Extracellular Space
	Molecular Function	Protein Binding Cholesterol Binding 5-aminolevulinic Acid Transmembrane Transporter Activity	Protein Binding Co-receptor Binding Receptor Antagonist Activity
	Biological Process	Intracellular Cholesterol Transport Lipid Droplet Organization Enucleate Erythrocyte Differentiation Import Across Plasma Membrane 5-aminolevulinic Acid Import Across Plasma Membrane	Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Hair Follicle Placode Formation Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways			TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists Signaling by LRP5 mutants
Drugs
Diseases
GWAS		Gastric cancer ( 26129866) Non-cardia gastric cancer ( 26129866)
Interacting Genes		62 interacting genes: AHNAK2 AQP6 ARL13B ASGR2 ASZ1 BIK CD53 CD69 CD79A CERS4 CLDN4 CNR2 COL4A5 CPLX4 CREB3L1 DKK4 EBP EFNA5 EMP1 ERGIC3 ERP29 FCER1G FCGR1A FFAR2 FKBP7 FNDC9 FXYD3 GGT7 GJB5 GPR152 GPR42 GPX8 IGFBP5 KCNJ6 KLRC1 LRRC59 MAL MARCHF2 MFF MFSD6 MS4A1 PDZK1IP1 PLEKHO1 PSCA RELL2 RETREG3 RPRM SLC10A1 SLC10A6 SLC16A2 SLC18A1 SLC34A2 SLC35H1 SLC41A3 SLC7A1 SPAG4 STOM SYT2 TMEM140 TMEM54 TMEM80 VSIR	3 interacting genes: GIMAP5 ITGAM TSPO2
Entrez ID		222642	27121
HPRD ID		16569	05660
Ensembl ID		ENSG00000112212	ENSG00000104371
Uniprot IDs		Q5TGU0	Q9UBT3
PDB IDs			5O57
Enriched GO Terms of Interacting Partners?		Membrane Plasma Membrane Protein Binding Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I External Side Of Plasma Membrane Positive Regulation Of Type III Hypersensitivity Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Type IIa Hypersensitivity Positive Regulation Of Acute Inflammatory Response Bile Acid:sodium Symporter Activity Transmembrane Transport Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Hypersensitivity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Antigen Processing And Presentation Of Exogenous Peptide Antigen Sodium Ion Transport Regulation Of Acute Inflammatory Response Antigen Processing And Presentation Of Exogenous Antigen Immune Response-regulating Signaling Pathway Serotonin Transport	ErbB-3 Class Receptor Binding Positive Regulation Of Peptidyl-tyrosine Autophosphorylation ERBB2-ERBB4 Signaling Pathway Integrin Binding Endocardial Cell Differentiation Nickel Cation Binding Integrin AlphaM-beta2 Complex Negative Regulation Of Dopamine Metabolic Process Positive Regulation Of Microglial Cell Mediated Cytotoxicity Positive Regulation Of Neutrophil Degranulation Response To Curcumin Complement-mediated Synapse Pruning Negative Regulation Of Catecholamine Metabolic Process Vertebrate Eye-specific Patterning Ectodermal Cell Differentiation 5-aminolevulinic Acid Import Across Plasma Membrane 5-aminolevulinic Acid Transmembrane Transporter Activity Ventricular Cardiac Muscle Cell Differentiation Positive Regulation Of Protein Autophosphorylation ERBB4-ERBB4 Signaling Pathway Regulation Of Neutrophil Degranulation Response To Gram-positive Bacterium Enucleate Erythrocyte Differentiation Activation Of Protein Kinase B Activity ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB4 Signaling Pathway Synapse Pruning Cardiac Muscle Cell Myoblast Differentiation Complement Component C3b Binding Ventricular Trabecula Myocardium Morphogenesis Cardioblast Differentiation Regulation Of Protein Autophosphorylation Complement Receptor Mediated Signaling Pathway Protein Tyrosine Kinase Activator Activity Stem Cell Development Mammary Gland Development Positive Regulation Of Heart Growth Endothelial Cell Differentiation Heart Trabecula Morphogenesis Cardiac Muscle Cell Differentiation Myoblast Differentiation Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Peripheral Nervous System Development Negative Regulation Of Striated Muscle Cell Apoptotic Process Neural Crest Cell Development ERBB2 Signaling Pathway Positive Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Secretion
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