TSPO2 and CNR2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TSPO2	CNR2
Description		translocator protein 2	cannabinoid receptor 2
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Organelle Membrane	Cytoplasm Endoplasmic Reticulum Plasma Membrane Membrane Dendrite Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cell Projection Neuronal Cell Body Perikaryon Postsynaptic Membrane
	Molecular Function	Protein Binding Cholesterol Binding 5-aminolevulinic Acid Transmembrane Transporter Activity	G Protein-coupled Receptor Activity Cannabinoid Receptor Activity Protein Binding
	Biological Process	Intracellular Cholesterol Transport Lipid Droplet Organization Enucleate Erythrocyte Differentiation Import Across Plasma Membrane 5-aminolevulinic Acid Import Across Plasma Membrane	Response To Amphetamine Inflammatory Response Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Leukocyte Chemotaxis Negative Regulation Of Synaptic Transmission, GABAergic Response To Lipopolysaccharide Negative Regulation Of Mast Cell Activation Cannabinoid Signaling Pathway Negative Regulation Of Action Potential Trans-synaptic Signaling By Endocannabinoid, Modulating Synaptic Transmission
Pathways			Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events
Drugs			Dronabinol Nabilone Ricinoleic acid Lasofoxifene Cannabidiol Tetrahydrocannabivarin Medical Cannabis Nabiximols S-777469
Diseases
GWAS		Gastric cancer ( 26129866) Non-cardia gastric cancer ( 26129866)	Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular volume ( 32888494) Multiple sclerosis ( 31604244) Psychotic experience (distressing) ( 31553412)
Interacting Genes		62 interacting genes: AHNAK2 AQP6 ARL13B ASGR2 ASZ1 BIK CD53 CD69 CD79A CERS4 CLDN4 CNR2 COL4A5 CPLX4 CREB3L1 DKK4 EBP EFNA5 EMP1 ERGIC3 ERP29 FCER1G FCGR1A FFAR2 FKBP7 FNDC9 FXYD3 GGT7 GJB5 GPR152 GPR42 GPX8 IGFBP5 KCNJ6 KLRC1 LRRC59 MAL MARCHF2 MFF MFSD6 MS4A1 PDZK1IP1 PLEKHO1 PSCA RELL2 RETREG3 RPRM SLC10A1 SLC10A6 SLC16A2 SLC18A1 SLC34A2 SLC35H1 SLC41A3 SLC7A1 SPAG4 STOM SYT2 TMEM140 TMEM54 TMEM80 VSIR	24 interacting genes: ADAM21 ADIPOQ AGPAT4 CCL4 COMT FXYD3 GNA15 MUC15 NRM PEDS1-UBE2V1 RFT1 SELENOK SLC35E4 SLC39A2 TMEM19 TMEM203 TMEM242 TMEM60 TMEM86A TMPPE TSPO2 YIPF1 YIPF4 YIPF6
Entrez ID		222642	1269
HPRD ID		16569	05444
Ensembl ID		ENSG00000112212	ENSG00000188822
Uniprot IDs		Q5TGU0	P34972
PDB IDs			2KI9 5ZTY 6KPC 6KPF 6PT0 8GUQ 8GUR 8GUS 8GUT 8X3L
Enriched GO Terms of Interacting Partners?		Membrane Plasma Membrane Protein Binding Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I External Side Of Plasma Membrane Positive Regulation Of Type III Hypersensitivity Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Type IIa Hypersensitivity Positive Regulation Of Acute Inflammatory Response Bile Acid:sodium Symporter Activity Transmembrane Transport Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Hypersensitivity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Antigen Processing And Presentation Of Exogenous Peptide Antigen Sodium Ion Transport Regulation Of Acute Inflammatory Response Antigen Processing And Presentation Of Exogenous Antigen Immune Response-regulating Signaling Pathway Serotonin Transport	Membrane Golgi Trans Cisterna Golgi Medial Cisterna Endoplasmic Reticulum Positive Regulation Of Monocyte Chemotactic Protein-1 Production
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