CNR2 and ADAM21

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CNR2	ADAM21
Description		cannabinoid receptor 2	ADAM metallopeptidase domain 21
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Plasma Membrane Membrane Dendrite Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cell Projection Neuronal Cell Body Perikaryon Postsynaptic Membrane	Plasma Membrane External Side Of Plasma Membrane Membrane Axon Neuron Projection Neuronal Cell Body Sperm Head Plasma Membrane
	Molecular Function	G Protein-coupled Receptor Activity Cannabinoid Receptor Activity Protein Binding	Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Response To Amphetamine Inflammatory Response Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Leukocyte Chemotaxis Negative Regulation Of Synaptic Transmission, GABAergic Response To Lipopolysaccharide Negative Regulation Of Mast Cell Activation Cannabinoid Signaling Pathway Negative Regulation Of Action Potential Trans-synaptic Signaling By Endocannabinoid, Modulating Synaptic Transmission	Proteolysis Single Fertilization Male Gonad Development
Pathways		Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events	Interaction With Cumulus Cells And The Zona Pellucida
Drugs		Dronabinol Nabilone Ricinoleic acid Lasofoxifene Cannabidiol Tetrahydrocannabivarin Medical Cannabis Nabiximols S-777469
Diseases
GWAS		Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular volume ( 32888494) Multiple sclerosis ( 31604244) Psychotic experience (distressing) ( 31553412)	Motor coordination ( 34177493) Plasma estrone levels in resected estrogen-receptor positive breast cancer ( 28429243)
Interacting Genes		24 interacting genes: ADAM21 ADIPOQ AGPAT4 CCL4 COMT FXYD3 GNA15 MUC15 NRM PEDS1-UBE2V1 RFT1 SELENOK SLC35E4 SLC39A2 TMEM19 TMEM203 TMEM242 TMEM60 TMEM86A TMPPE TSPO2 YIPF1 YIPF4 YIPF6	2 interacting genes: CNR2 SGTA
Entrez ID		1269	8747
HPRD ID		05444	04755
Ensembl ID		ENSG00000188822	ENSG00000139985
Uniprot IDs		P34972	Q9UKJ8
PDB IDs		2KI9 5ZTY 6KPC 6KPF 6PT0 8GUQ 8GUR 8GUS 8GUT 8X3L
Enriched GO Terms of Interacting Partners?		Membrane Golgi Trans Cisterna Golgi Medial Cisterna Endoplasmic Reticulum Positive Regulation Of Monocyte Chemotactic Protein-1 Production	Cannabinoid Receptor Activity Negative Regulation Of Action Potential Trans-synaptic Signaling By Endocannabinoid, Modulating Synaptic Transmission Cannabinoid Signaling Pathway Negative Regulation Of Synaptic Transmission, GABAergic TRC Complex BAT3 Complex Binding Negative Regulation Of ERAD Pathway Negative Regulation Of Mast Cell Activation Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Trans-synaptic Signaling, Modulating Synaptic Transmission Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Tail-anchored Membrane Protein Insertion Into ER Membrane Regulation Of Mast Cell Activation Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Response To Amphetamine Protein Insertion Into ER Membrane Protein Targeting To ER Regulation Of Synaptic Transmission, GABAergic Establishment Of Protein Localization To Endoplasmic Reticulum Negative Regulation Of Synaptic Transmission Positive Regulation Of Response To Endoplasmic Reticulum Stress Response To Amine Negative Regulation Of Response To Endoplasmic Reticulum Stress G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Action Potential Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Protein Targeting To Membrane Protein Insertion Into Membrane Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway
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