CNR2 and GNA15

Number of citations of the paper that reports this interaction (PMID 12095632)
2

Data Source:
HPRD (in vivo)

		CNR2	GNA15
Gene Name		cannabinoid receptor 2 (macrophage)	guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Dendrite Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Perikaryon	Heterotrimeric G-protein Complex Plasma Membrane
	Molecular Function	Cannabinoid Receptor Activity	G-protein Coupled Receptor Binding GTPase Activity Signal Transducer Activity GTP Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding
	Biological Process	Response To Amphetamine Inflammatory Response Immune Response G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Sensory Perception Of Pain Negative Regulation Of Synaptic Transmission, GABAergic Response To Lipopolysaccharide Negative Regulation Of Mast Cell Activation Cannabinoid Signaling Pathway Negative Regulation Of Action Potential Negative Regulation Of Inflammatory Response Negative Regulation Of Nitric-oxide Synthase Activity	Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Phospholipase C-activating G-protein Coupled Acetylcholine Receptor Signaling Pathway Blood Coagulation Platelet Activation Phospholipase C-activating Dopamine Receptor Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	G alpha (q) signalling events Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Signaling by GPCR ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism Regulation of insulin secretion Signal amplification Thrombin signalling through proteinase activated receptors (PARs) G alpha (q) signalling events GPCR downstream signaling Acetylcholine regulates insulin secretion Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor Platelet activation, signaling and aggregation Free fatty acids regulate insulin secretion
Drugs		Dronabinol Nabilone
Diseases
GWAS			Heart failure ( 20445134)
Protein-Protein Interactions		1 interactors: GNA15	19 interactors: ADRB2 ADRBK1 APP CHRM2 CNR1 CNR2 CXCR1 CXCR2 F2R GRM2 GRM4 HRH4 LTB4R OPRD1 OPRK1 OPRM1 PRKCA RGS2 TTC1
Entrez ID		1269	2769
HPRD ID		05444	00760
Ensembl ID		ENSG00000188822	ENSG00000060558
Uniprot IDs		C6ES44 P34972	P30679
PDB IDs		2KI9
Enriched GO Terms of Interacting Partners?		Phospholipase C-activating G-protein Coupled Acetylcholine Receptor Signaling Pathway Phospholipase C-activating Dopamine Receptor Signaling Pathway G-protein Coupled Acetylcholine Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Phospholipase C Activity Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Phospholipase Activity Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Cytosolic Calcium Ion Concentration Cytosolic Calcium Ion Homeostasis Platelet Activation Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Cellular Metal Ion Homeostasis Blood Coagulation Hemostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Cellular Chemical Homeostasis Ion Homeostasis Regulation Of Body Fluid Levels Wound Healing Cell Activation Cellular Homeostasis Response To Wounding	G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Defense Response Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Signaling Cell Communication Sensory Perception Of Pain Cellular Metal Ion Homeostasis Inflammatory Response Response To External Stimulus Opioid Receptor Signaling Pathway Cellular Cation Homeostasis Cellular Response To Stimulus Cellular Ion Homeostasis Metal Ion Homeostasis Regulation Of Phosphorus Metabolic Process Cellular Chemical Homeostasis Blood Circulation Regulation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Muscle Contraction Response To Stress Chemical Homeostasis Ion Homeostasis Synaptic Transmission Regulation Of Cyclase Activity Immune Response Regulation Of Phosphorylation Cytosolic Calcium Ion Homeostasis Regulation Of MAPK Cascade Regulation Of Catalytic Activity Homeostatic Process Regulation Of Signaling Interleukin-8-mediated Signaling Pathway Adenylate Cyclase-inhibiting Opioid Receptor Signaling Pathway Cellular Homeostasis Negative Regulation Of Muscle Contraction Negative Regulation Of Adenylate Cyclase Activity Regulation Of CAMP Biosynthetic Process Negative Regulation Of Lyase Activity Response To Stimulus Regulation Of CAMP Metabolic Process Regulation Of Sensory Perception Of Pain Negative Regulation Of Catalytic Activity
Tagcloud ?		abstract acts autoimmune cannabinoid case cb2 cb2r diseases drugs due era heterogeneous immune itp k2 literature marijuana mimetics pathogenesis polymorphisms prednisolone presented receptors secondary successfully synthetic thrombocytes thrombocytopenia usage
Tagcloud (Difference) ?		abstract acts autoimmune cannabinoid case cb2 cb2r diseases drugs due era heterogeneous immune itp k2 literature marijuana mimetics pathogenesis polymorphisms prednisolone presented receptors secondary successfully synthetic thrombocytes thrombocytopenia usage
Tagcloud (Intersection) ?