FCER1A and FCER1G

Number of citations of the paper that reports this interaction (PMID 8752908)
28

Data Source:
HPRD (in vivo)

		FCER1A	FCER1G
Gene Name		Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide	Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Fc-epsilon Receptor I Complex
	Molecular Function	IgE Receptor Activity IgE Binding	Protein Binding IgE Receptor Activity IgE Binding IgG Binding
	Biological Process	Positive Regulation Of Type I Hypersensitivity Serotonin Secretion Activation Of JUN Kinase Activity Leukotriene Biosynthetic Process Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Mast Cell Degranulation Innate Immune Response Positive Regulation Of Interleukin-3 Biosynthetic Process Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Calcium-mediated Signaling	Positive Regulation Of Type IIa Hypersensitivity Positive Regulation Of Type III Hypersensitivity Positive Regulation Of Type I Hypersensitivity Neutrophil Activation Involved In Immune Response Fc Receptor Mediated Stimulatory Signaling Pathway Serotonin Secretion By Platelet Phagocytosis, Engulfment Integrin-mediated Signaling Pathway Blood Coagulation Regulation Of Platelet Activation Immunoglobulin Mediated Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Platelet Activation Neutrophil Chemotaxis Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Mast Cell Cytokine Production Negative Regulation Of Mast Cell Apoptotic Process Fc-epsilon Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Defense Response To Bacterium Positive Regulation Of Mast Cell Degranulation Innate Immune Response Mast Cell Activation Positive Regulation Of Phagocytosis Leukocyte Migration Protein Localization To Plasma Membrane
Pathways		FCERI mediated NF-kB activation Fc epsilon receptor (FCERI) signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization Role of LAT2/NTAL/LAB on calcium mobilization Innate Immune System	Platelet Adhesion to exposed collagen FCERI mediated NF-kB activation GPVI-mediated activation cascade Fc epsilon receptor (FCERI) signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization Platelet activation, signaling and aggregation Role of LAT2/NTAL/LAB on calcium mobilization Cell surface interactions at the vascular wall Innate Immune System
Drugs		Omalizumab Benzylpenicilloyl Polylysine Alpha-D-Mannose	Benzylpenicilloyl Polylysine
Diseases
GWAS		C-reactive protein ( 22939635) IgE levels ( 18846228 22075330) Obesity-related traits ( 23251661) Select biomarker traits ( 17903293)
Protein-Protein Interactions		4 interactors: FCER1G ITIH2 MS4A2 PDHB	8 interactors: FCER1A FCGR3A GP6 KIR2DL4 LYN NCR1 PLCG2 SYK
Entrez ID		2205	2207
HPRD ID		00917	00916
Ensembl ID		ENSG00000179639	ENSG00000158869
Uniprot IDs		P12319	P30273
PDB IDs		1ALS 1ALT 1F2Q 1F6A 1J86 1J87 1J88 1J89 1RPQ 2Y7Q
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Mast Cell Degranulation Positive Regulation Of Mast Cell Activation Positive Regulation Of Regulated Secretory Pathway Regulation Of Mast Cell Degranulation Regulation Of Mast Cell Activation Regulation Of Regulated Secretory Pathway Positive Regulation Of Exocytosis Positive Regulation Of Type III Hypersensitivity Regulation Of Exocytosis Acetyl-CoA Biosynthetic Process From Pyruvate Positive Regulation Of Mast Cell Cytokine Production Positive Regulation Of Type I Hypersensitivity Serotonin Secretion By Platelet Positive Regulation Of Type IIa Hypersensitivity Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Intracellular Transport Fc Receptor Signaling Pathway Serotonin Secretion Acetyl-CoA Biosynthetic Process Positive Regulation Of Cell Activation Negative Regulation Of Mast Cell Apoptotic Process Positive Regulation Of Secretion Regulation Of Mast Cell Apoptotic Process Serotonin Transport Positive Regulation Of Hypersensitivity Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Vesicle-mediated Transport Neutrophil Activation Involved In Immune Response Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Inflammatory Response Regulation Of Intracellular Transport Positive Regulation Of Inflammatory Response To Antigenic Stimulus Phagocytosis, Engulfment Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Secretion By Cell Regulation Of Acyl-CoA Biosynthetic Process Membrane Invagination Negative Regulation Of Myeloid Cell Apoptotic Process Acetyl-CoA Metabolic Process Neutrophil Activation Secretion Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Positive Regulation Of Immune Response Regulation Of Secretion Monoamine Transport Positive Regulation Of Acute Inflammatory Response Production Of Molecular Mediator Involved In Inflammatory Response Positive Regulation Of Interleukin-10 Production	Regulation Of Immune Response Fc Receptor Signaling Pathway Regulation Of Immune System Process Defense Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Mast Cell Degranulation Positive Regulation Of Interleukin-3 Biosynthetic Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Mast Cell Activation B Cell Receptor Signaling Pathway Regulation Of Regulated Secretory Pathway Response To Stress Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Platelet Activation Immune System Process Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Immune Response Serotonin Secretion Phagocytosis Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Ammonium Transport Serotonin Transport Innate Immune Response Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Immune System Process Signal Transduction Blood Coagulation Hemostasis Positive Regulation Of Mast Cell Degranulation Positive Regulation Of Mast Cell Activation Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Signaling Leukocyte Activation Regulation Of Platelet Aggregation Cell Communication Regulation Of Exocytosis Leukocyte Activation Involved In Immune Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Regulated Secretory Pathway Regulation Of Body Fluid Levels Immune Response Leukotriene Biosynthetic Process Wound Healing Monoamine Transport
Tagcloud ?		adam33 allergen allergens allergic black boston cnot6 cockroach dataset dust genotypic haplotype haplotypes house il5ra jak3 maml1 marginally mite nod1 rs11739089 rs12136904t rs6665683 rs6665683t rs7851969 sensitization sensitizations snps strongest
Tagcloud (Difference) ?		adam33 allergen allergens allergic black boston cnot6 cockroach dataset dust genotypic haplotype haplotypes house il5ra jak3 maml1 marginally mite nod1 rs11739089 rs12136904t rs6665683 rs6665683t rs7851969 sensitization sensitizations snps strongest
Tagcloud (Intersection) ?