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FCER1A
Gene Name
Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
Image
Gene Ontology Annotations
Cellular Component
Plasma Membrane
Integral Component Of Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Molecular Function
IgE Receptor Activity
IgE Binding
Biological Process
Positive Regulation Of Type I Hypersensitivity
Serotonin Secretion
Activation Of JUN Kinase Activity
Leukotriene Biosynthetic Process
Fc-epsilon Receptor Signaling Pathway
Positive Regulation Of Mast Cell Degranulation
Innate Immune Response
Positive Regulation Of Interleukin-3 Biosynthetic Process
Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Calcium-mediated Signaling
Pathways
FCERI mediated NF-kB activation
Fc epsilon receptor (FCERI) signaling
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
Role of LAT2/NTAL/LAB on calcium mobilization
Innate Immune System
Drugs
Omalizumab
Benzylpenicilloyl Polylysine
Alpha-D-Mannose
Diseases
GWAS
C-reactive protein (
22939635
)
IgE levels (
18846228
22075330
)
Obesity-related traits (
23251661
)
Select biomarker traits (
17903293
)
Protein-protein Interactions
4 interactors:
FCER1G
ITIH2
MS4A2
PDHB
Entrez ID
2205
HPRD ID
00917
Ensembl ID
ENSG00000179639
Uniprot IDs
P12319
PDB IDs
1ALS
1ALT
1F2Q
1F6A
1J86
1J87
1J88
1J89
1RPQ
2Y7Q
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Mast Cell Degranulation
Positive Regulation Of Mast Cell Activation
Positive Regulation Of Regulated Secretory Pathway
Regulation Of Mast Cell Degranulation
Regulation Of Mast Cell Activation
Regulation Of Regulated Secretory Pathway
Positive Regulation Of Exocytosis
Positive Regulation Of Type III Hypersensitivity
Regulation Of Exocytosis
Acetyl-CoA Biosynthetic Process From Pyruvate
Positive Regulation Of Mast Cell Cytokine Production
Positive Regulation Of Type I Hypersensitivity
Serotonin Secretion By Platelet
Positive Regulation Of Type IIa Hypersensitivity
Fc-epsilon Receptor Signaling Pathway
Positive Regulation Of Intracellular Transport
Fc Receptor Signaling Pathway
Serotonin Secretion
Acetyl-CoA Biosynthetic Process
Positive Regulation Of Cell Activation
Negative Regulation Of Mast Cell Apoptotic Process
Positive Regulation Of Secretion
Regulation Of Mast Cell Apoptotic Process
Serotonin Transport
Positive Regulation Of Hypersensitivity
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Regulation Of Vesicle-mediated Transport
Neutrophil Activation Involved In Immune Response
Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus
Inflammatory Response
Regulation Of Intracellular Transport
Positive Regulation Of Inflammatory Response To Antigenic Stimulus
Phagocytosis, Engulfment
Immune Response-regulating Signaling Pathway
Regulation Of Cell Activation
Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate
Secretion By Cell
Regulation Of Acyl-CoA Biosynthetic Process
Membrane Invagination
Negative Regulation Of Myeloid Cell Apoptotic Process
Acetyl-CoA Metabolic Process
Neutrophil Activation
Secretion
Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response
Positive Regulation Of Immune Response
Regulation Of Secretion
Monoamine Transport
Positive Regulation Of Acute Inflammatory Response
Production Of Molecular Mediator Involved In Inflammatory Response
Positive Regulation Of Interleukin-10 Production
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allergen
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cockroach
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dust
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il5ra
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