FCER1A and PDHB

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		FCER1A	PDHB
Description		Fc epsilon receptor Ia	pyruvate dehydrogenase E1 subunit beta
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GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Pyruvate Dehydrogenase Complex
	Molecular Function	Protein Binding High-affinity IgE Receptor Activity IgE Binding	Pyruvate Dehydrogenase (acetyl-transferring) Activity Protein Binding Oxidoreductase Activity Metal Ion Binding
	Biological Process	Cell Surface Receptor Signaling Pathway Immunoglobulin Mediated Immune Response Type I Hypersensitivity Fc-epsilon Receptor Signaling Pathway Type 2 Immune Response Mast Cell Degranulation Eosinophil Degranulation	Glucose Metabolic Process Pyruvate Decarboxylation To Acetyl-CoA Tricarboxylic Acid Cycle Purine-containing Compound Biosynthetic Process
Pathways		Fc epsilon receptor (FCERI) signaling Fc epsilon receptor (FCERI) signaling Role of LAT2/NTAL/LAB on calcium mobilization Role of LAT2/NTAL/LAB on calcium mobilization FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization FCERI mediated NF-kB activation	Regulation of pyruvate dehydrogenase (PDH) complex Signaling by Retinoic Acid Mitochondrial protein degradation PDH complex synthesizes acetyl-CoA from PYR
Drugs		Omalizumab Benzylpenicilloyl polylysine TNX-901	Pyruvic acid NADH
Diseases			Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome
GWAS		C-reactive protein ( 22939635) IgE levels ( 18846228 22075330) Obesity-related traits ( 23251661) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912) Select biomarker traits ( 17903293) White blood cell count ( 27863252)	Apolipoprotein B levels ( 32203549) Composite immunoglobulin trait (IgA x IgG/IgM) ( 28628107) IgG levels ( 28628107) LDL cholesterol levels ( 32203549) Refractive error ( 32231278) Systemic lupus erythematosus ( 26502338 28714469) Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event) ( 29310926) vWF levels ( 30586737)
Interacting Genes		6 interacting genes: FCER1G ITIH2 LMNA MESD MS4A2 PDHB	18 interacting genes: ADORA2A AKT1 ANXA7 CDKN1A FCER1A GNB2 GRB7 HSD17B10 ITGB1 PDHA1 PDHA2 PDHX PFDN1 RAP1B RBM11 RCC1 TRIM63 TSC22D1
Entrez ID		2205	5162
HPRD ID		00917	01530
Ensembl ID		ENSG00000179639	ENSG00000168291
Uniprot IDs		E9PRN1 P12319	A0A384MDR8 P11177
PDB IDs		1F2Q 1F6A 1J86 1J87 1J88 1J89 1RPQ 2Y7Q 7SHT 8C1B 8C1C 8K7R 8YVU 8YWA 8Z0T 9EQ3 9EQ4	1NI4 2OZL 3EXE 3EXF 3EXG 3EXH 3EXI 6CER 6CFO
Enriched GO Terms of Interacting Partners?		Fc-epsilon Receptor I Complex IgE Binding IgG Binding Fc-gamma Receptor Signaling Pathway Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Fc Receptor Signaling Pathway External Side Of Plasma Membrane Positive Regulation Of Phagocytosis IgE Receptor Activity Positive Regulation Of Type I Hypersensitivity Negative Regulation Of Mast Cell Apoptotic Process Regulation Of Phagocytosis Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Tumor Necrosis Factor Production Localization Within Membrane Serotonin Secretion By Platelet Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Lymphocyte Mediated Immunity Fc-gamma Receptor III Complex Positive Regulation Of Type III Hypersensitivity DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina Pyruvate Dehydrogenase (acetyl-transferring) Activity Mast Cell Apoptotic Process Serotonin Secretion Positive Regulation Of Type IIa Hypersensitivity Leukocyte Mediated Immunity Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Positive Regulation Of Endocytosis Positive Regulation Of Mast Cell Cytokine Production Regulation Of Mast Cell Apoptotic Process Lamin Filament Nuclear Pore Localization Regulation Of Tumor Necrosis Factor Production Protein Localization To Plasma Membrane IgG Receptor Activity Positive Regulation Of Hypersensitivity Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Interleukin-3-mediated Signaling Pathway Mast Cell Activation Antibody-dependent Cellular Cytotoxicity Negative Regulation Of Mesenchymal Cell Proliferation Pyruvate Decarboxylation To Acetyl-CoA Pyruvate Dehydrogenase Complex Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Protein Localization To Cell Periphery Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Ventricular Cardiac Muscle Cell Development	Pyruvate Decarboxylation To Acetyl-CoA Pyruvate Dehydrogenase Complex Acetyl-CoA Biosynthetic Process Pyruvate Dehydrogenase (acetyl-transferring) Activity Acetyl-CoA Metabolic Process Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, Disulfide As Acceptor Protein-containing Complex Binding Pyruvate Metabolic Process Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Fibroblast Migration Acyl-CoA Metabolic Process Sulfur Compound Biosynthetic Process Positive Regulation Of Amino Acid Transport Cell Migration Involved In Sprouting Angiogenesis Glucose Metabolic Process Cellular Response To Low-density Lipoprotein Particle Stimulus Tricarboxylic Acid Cycle Amide Biosynthetic Process Cellular Response To Lipoprotein Particle Stimulus Regulation Of Fibroblast Migration Carboxylic Acid Metabolic Process TRNA Methylation Organic Acid Metabolic Process Monosaccharide Metabolic Process Hexose Metabolic Process Blood Vessel Endothelial Cell Migration Regulation Of TRNA Methylation Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition High-affinity IgE Receptor Activity Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity Cholate 7-alpha-dehydrogenase (NAD+) Activity Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Mitochondrial Matrix Myoblast Fate Specification Integrin Alpha7-beta1 Complex Cellular Defense Response Protein Kinase Binding Monocarboxylic Acid Metabolic Process Excitatory Postsynaptic Potential Cellular Response To Amino Acid Starvation Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Protein Localization To Lysosome PCNA-p21 Complex Negative Regulation Of Cardiac Muscle Tissue Regeneration Type I Hypersensitivity 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity
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