FCER1A and PDHB

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		FCER1A	PDHB
Gene Name		Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide	pyruvate dehydrogenase (lipoamide) beta
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Pyruvate Dehydrogenase Complex Extracellular Vesicular Exosome
	Molecular Function	IgE Receptor Activity IgE Binding	Pyruvate Dehydrogenase Activity Pyruvate Dehydrogenase (acetyl-transferring) Activity Protein Binding
	Biological Process	Positive Regulation Of Type I Hypersensitivity Serotonin Secretion Activation Of JUN Kinase Activity Leukotriene Biosynthetic Process Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Mast Cell Degranulation Innate Immune Response Positive Regulation Of Interleukin-3 Biosynthetic Process Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Calcium-mediated Signaling	Glucose Metabolic Process Acetyl-CoA Biosynthetic Process From Pyruvate Pyruvate Metabolic Process Tricarboxylic Acid Cycle Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Cellular Metabolic Process Small Molecule Metabolic Process
Pathways		FCERI mediated NF-kB activation Fc epsilon receptor (FCERI) signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization Role of LAT2/NTAL/LAB on calcium mobilization Innate Immune System	Regulation of pyruvate dehydrogenase (PDH) complex Pyruvate metabolism Signaling by Retinoic Acid Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport
Drugs		Omalizumab Benzylpenicilloyl Polylysine Alpha-D-Mannose	Pyruvic acid NADH
Diseases
GWAS		C-reactive protein ( 22939635) IgE levels ( 18846228 22075330) Obesity-related traits ( 23251661) Select biomarker traits ( 17903293)
Protein-Protein Interactions		4 interactors: FCER1G ITIH2 MS4A2 PDHB	15 interactors: ANXA7 CDKN1A DLAT FCER1A GNB2 GRB7 ITGB1 PDHA1 PDHA2 PDHX PFDN1 RAP1B RCC1 TRIM63 TSC22D1
Entrez ID		2205	5162
HPRD ID		00917	01530
Ensembl ID		ENSG00000179639	ENSG00000168291
Uniprot IDs		P12319	P11177
PDB IDs		1ALS 1ALT 1F2Q 1F6A 1J86 1J87 1J88 1J89 1RPQ 2Y7Q	1NI4 2OZL 3EXE 3EXF 3EXG 3EXH 3EXI
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Mast Cell Degranulation Positive Regulation Of Mast Cell Activation Positive Regulation Of Regulated Secretory Pathway Regulation Of Mast Cell Degranulation Regulation Of Mast Cell Activation Regulation Of Regulated Secretory Pathway Positive Regulation Of Exocytosis Positive Regulation Of Type III Hypersensitivity Regulation Of Exocytosis Acetyl-CoA Biosynthetic Process From Pyruvate Positive Regulation Of Mast Cell Cytokine Production Positive Regulation Of Type I Hypersensitivity Serotonin Secretion By Platelet Positive Regulation Of Type IIa Hypersensitivity Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Intracellular Transport Fc Receptor Signaling Pathway Serotonin Secretion Acetyl-CoA Biosynthetic Process Positive Regulation Of Cell Activation Negative Regulation Of Mast Cell Apoptotic Process Positive Regulation Of Secretion Regulation Of Mast Cell Apoptotic Process Serotonin Transport Positive Regulation Of Hypersensitivity Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Vesicle-mediated Transport Neutrophil Activation Involved In Immune Response Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Inflammatory Response Regulation Of Intracellular Transport Positive Regulation Of Inflammatory Response To Antigenic Stimulus Phagocytosis, Engulfment Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Secretion By Cell Regulation Of Acyl-CoA Biosynthetic Process Membrane Invagination Negative Regulation Of Myeloid Cell Apoptotic Process Acetyl-CoA Metabolic Process Neutrophil Activation Secretion Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Positive Regulation Of Immune Response Regulation Of Secretion Monoamine Transport Positive Regulation Of Acute Inflammatory Response Production Of Molecular Mediator Involved In Inflammatory Response Positive Regulation Of Interleukin-10 Production	Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Acyl-CoA Biosynthetic Process Pyruvate Metabolic Process Tricarboxylic Acid Cycle Citrate Metabolic Process Tricarboxylic Acid Metabolic Process Aerobic Respiration Regulation Of Cellular Ketone Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Metabolic Process Monocarboxylic Acid Metabolic Process Regulation Of Fatty Acid Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Glucose Metabolic Process Generation Of Precursor Metabolites And Energy G1/S Transition Of Mitotic Cell Cycle Hemostasis Response To Organic Cyclic Compound Cellular Respiration Hexose Metabolic Process Carboxylic Acid Metabolic Process Regulation Of Body Fluid Levels Monosaccharide Metabolic Process Mitotic Cell Cycle Phase Transition Cellular Response To Ionizing Radiation Organic Acid Metabolic Process Regulation Of Cellular Process Cell Cycle Phase Transition Regulation Of Lipid Metabolic Process Positive Regulation Of Protein Phosphorylation Positive Regulation Of Interleukin-3 Biosynthetic Process Positive Regulation Of Type I Hypersensitivity Regulation Of Vesicle-mediated Transport Positive Regulation Of Phosphorylation Glycolytic Process Cellular Response To Organic Cyclic Compound Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Regulation Of Collagen Catabolic Process Positive Regulation Of Protein Modification Process Small Molecule Metabolic Process Blood Coagulation Positive Regulation Of MAPK Cascade Response To Hormone Negative Regulation Of Synaptic Vesicle Exocytosis Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Calcium-independent Cell-matrix Adhesion Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Acetyl-CoA Biosynthetic Process From Pyruvate Positive Regulation Of Protein Kinase Activity Response To Organic Substance
Tagcloud ?		adam33 allergen allergens allergic black boston cnot6 cockroach dataset dust genotypic haplotype haplotypes house il5ra jak3 maml1 marginally mite nod1 rs11739089 rs12136904t rs6665683 rs6665683t rs7851969 sensitization sensitizations snps strongest	actg1 alteration birc7 chrcc chromophobe cpq distinctions ectopic enabled exome faah2 fusions met mitf mutated nccrccs nf2 oncocytoma oncocytomas papillary pdxdc1 pnkd prcc rcc slc5a3 transcriptome trcc unreported znf765
Tagcloud (Difference) ?		adam33 allergen allergens allergic black boston cnot6 cockroach dataset dust genotypic haplotype haplotypes house il5ra jak3 maml1 marginally mite nod1 rs11739089 rs12136904t rs6665683 rs6665683t rs7851969 sensitization sensitizations snps strongest	actg1 alteration birc7 chrcc chromophobe cpq distinctions ectopic enabled exome faah2 fusions met mitf mutated nccrccs nf2 oncocytoma oncocytomas papillary pdxdc1 pnkd prcc rcc slc5a3 transcriptome trcc unreported znf765
Tagcloud (Intersection) ?