FCER1A and MS4A2

Number of citations of the paper that reports this interaction (PMID 1535625)
10

Data Source:
HPRD (in vivo)

		FCER1A	MS4A2
Gene Name		Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide	membrane-spanning 4-domains, subfamily A, member 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface	Endosome Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Fc-epsilon Receptor I Complex Membrane Raft
	Molecular Function	IgE Receptor Activity IgE Binding	IgE Receptor Activity IgE Binding Protein Kinase Binding SH2 Domain Binding Phosphoprotein Binding
	Biological Process	Positive Regulation Of Type I Hypersensitivity Serotonin Secretion Activation Of JUN Kinase Activity Leukotriene Biosynthetic Process Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Mast Cell Degranulation Innate Immune Response Positive Regulation Of Interleukin-3 Biosynthetic Process Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Calcium-mediated Signaling	Inflammatory Response Immune Response Activation Of Phospholipase C Activity Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Mast Cell Degranulation Innate Immune Response Cytokine Secretion Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Pathways		FCERI mediated NF-kB activation Fc epsilon receptor (FCERI) signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization Role of LAT2/NTAL/LAB on calcium mobilization Innate Immune System	FCERI mediated NF-kB activation Fc epsilon receptor (FCERI) signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization Role of LAT2/NTAL/LAB on calcium mobilization Innate Immune System
Drugs		Omalizumab Benzylpenicilloyl Polylysine Alpha-D-Mannose
Diseases
GWAS		C-reactive protein ( 22939635) IgE levels ( 18846228 22075330) Obesity-related traits ( 23251661) Select biomarker traits ( 17903293)
Protein-Protein Interactions		4 interactors: FCER1G ITIH2 MS4A2 PDHB	10 interactors: AKT1 APP FCER1A GRB2 HSP90AA1 LYN PRKCD PTPN11 PTPN6 SYK
Entrez ID		2205	2206
HPRD ID		00917	00915
Ensembl ID		ENSG00000179639
Uniprot IDs		P12319	Q01362
PDB IDs		1ALS 1ALT 1F2Q 1F6A 1J86 1J87 1J88 1J89 1RPQ 2Y7Q
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Mast Cell Degranulation Positive Regulation Of Mast Cell Activation Positive Regulation Of Regulated Secretory Pathway Regulation Of Mast Cell Degranulation Regulation Of Mast Cell Activation Regulation Of Regulated Secretory Pathway Positive Regulation Of Exocytosis Positive Regulation Of Type III Hypersensitivity Regulation Of Exocytosis Acetyl-CoA Biosynthetic Process From Pyruvate Positive Regulation Of Mast Cell Cytokine Production Positive Regulation Of Type I Hypersensitivity Serotonin Secretion By Platelet Positive Regulation Of Type IIa Hypersensitivity Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Intracellular Transport Fc Receptor Signaling Pathway Serotonin Secretion Acetyl-CoA Biosynthetic Process Positive Regulation Of Cell Activation Negative Regulation Of Mast Cell Apoptotic Process Positive Regulation Of Secretion Regulation Of Mast Cell Apoptotic Process Serotonin Transport Positive Regulation Of Hypersensitivity Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Vesicle-mediated Transport Neutrophil Activation Involved In Immune Response Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Inflammatory Response Regulation Of Intracellular Transport Positive Regulation Of Inflammatory Response To Antigenic Stimulus Phagocytosis, Engulfment Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Secretion By Cell Regulation Of Acyl-CoA Biosynthetic Process Membrane Invagination Negative Regulation Of Myeloid Cell Apoptotic Process Acetyl-CoA Metabolic Process Neutrophil Activation Secretion Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Positive Regulation Of Immune Response Regulation Of Secretion Monoamine Transport Positive Regulation Of Acute Inflammatory Response Production Of Molecular Mediator Involved In Inflammatory Response Positive Regulation Of Interleukin-10 Production	Immune Response-regulating Cell Surface Receptor Signaling Pathway Innate Immune Response Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Platelet Activation Immune Response Defense Response Blood Coagulation Hemostasis Regulation Of Cell Activation Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Body Fluid Levels Positive Regulation Of Cell Activation Wound Healing Regulation Of MAPK Cascade Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Wounding Regulation Of Cell-cell Adhesion Regulation Of Protein Kinase Activity Regulation Of Cellular Amino Acid Metabolic Process Immune System Process Regulation Of Immune System Process Regulation Of Phosphorylation Regulation Of Kinase Activity T Cell Costimulation Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Phosphorus Metabolic Process Fc-epsilon Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Cell-cell Adhesion Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of MAP Kinase Activity Regulation Of T Cell Activation Regulation Of Protein Phosphorylation Regulation Of Cell Adhesion Positive Regulation Of Immune Response Regulation Of Cell Adhesion Mediated By Integrin Cell Activation Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Cell Adhesion Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Regulation Of Lymphocyte Activation
Tagcloud ?		adam33 allergen allergens allergic black boston cnot6 cockroach dataset dust genotypic haplotype haplotypes house il5ra jak3 maml1 marginally mite nod1 rs11739089 rs12136904t rs6665683 rs6665683t rs7851969 sensitization sensitizations snps strongest
Tagcloud (Difference) ?		adam33 allergen allergens allergic black boston cnot6 cockroach dataset dust genotypic haplotype haplotypes house il5ra jak3 maml1 marginally mite nod1 rs11739089 rs12136904t rs6665683 rs6665683t rs7851969 sensitization sensitizations snps strongest
Tagcloud (Intersection) ?