FCER1A and MS4A2

Number of citations of the paper that reports this interaction (PubMedID 1535625)
0

Data Source:
HPRD (in vivo)

		FCER1A	MS4A2
Description		Fc epsilon receptor Ia	membrane spanning 4-domains A2
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GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane	Plasma Membrane External Side Of Plasma Membrane Membrane Fc-epsilon Receptor I Complex
	Molecular Function	Protein Binding High-affinity IgE Receptor Activity IgE Binding	Protein Binding IgE Binding
	Biological Process	Cell Surface Receptor Signaling Pathway Immunoglobulin Mediated Immune Response Type I Hypersensitivity Fc-epsilon Receptor Signaling Pathway Type 2 Immune Response Mast Cell Degranulation Eosinophil Degranulation	Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway
Pathways		Fc epsilon receptor (FCERI) signaling Fc epsilon receptor (FCERI) signaling Role of LAT2/NTAL/LAB on calcium mobilization Role of LAT2/NTAL/LAB on calcium mobilization FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization FCERI mediated NF-kB activation	Fc epsilon receptor (FCERI) signaling Fc epsilon receptor (FCERI) signaling Role of LAT2/NTAL/LAB on calcium mobilization Role of LAT2/NTAL/LAB on calcium mobilization FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization FCERI mediated NF-kB activation
Drugs		Omalizumab Benzylpenicilloyl polylysine TNX-901	Omalizumab
Diseases			Asthma
GWAS		C-reactive protein ( 22939635) IgE levels ( 18846228 22075330) Obesity-related traits ( 23251661) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912) Select biomarker traits ( 17903293) White blood cell count ( 27863252)	Alzheimer's disease ( 31473137)
Interacting Genes		6 interacting genes: FCER1G ITIH2 LMNA MESD MS4A2 PDHB	12 interacting genes: AKT1 APP FCER1A GRB2 HSP90AA1 LYN PRKCD PTPN11 PTPN6 SNCA SYK TMEM86A
Entrez ID		2205	2206
HPRD ID		00917	00915
Ensembl ID		ENSG00000179639	ENSG00000149534
Uniprot IDs		E9PRN1 P12319	A0A0B4J2E9 Q01362
PDB IDs		1F2Q 1F6A 1J86 1J87 1J88 1J89 1RPQ 2Y7Q 7SHT 8C1B 8C1C 8K7R 8YVU 8YWA 8Z0T 9EQ3 9EQ4	8YVU 8YWA
Enriched GO Terms of Interacting Partners?		Fc-epsilon Receptor I Complex IgE Binding IgG Binding Fc-gamma Receptor Signaling Pathway Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Fc Receptor Signaling Pathway External Side Of Plasma Membrane Positive Regulation Of Phagocytosis IgE Receptor Activity Positive Regulation Of Type I Hypersensitivity Negative Regulation Of Mast Cell Apoptotic Process Regulation Of Phagocytosis Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Tumor Necrosis Factor Production Localization Within Membrane Serotonin Secretion By Platelet Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Lymphocyte Mediated Immunity Fc-gamma Receptor III Complex Positive Regulation Of Type III Hypersensitivity DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina Pyruvate Dehydrogenase (acetyl-transferring) Activity Mast Cell Apoptotic Process Serotonin Secretion Positive Regulation Of Type IIa Hypersensitivity Leukocyte Mediated Immunity Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Positive Regulation Of Endocytosis Positive Regulation Of Mast Cell Cytokine Production Regulation Of Mast Cell Apoptotic Process Lamin Filament Nuclear Pore Localization Regulation Of Tumor Necrosis Factor Production Protein Localization To Plasma Membrane IgG Receptor Activity Positive Regulation Of Hypersensitivity Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Interleukin-3-mediated Signaling Pathway Mast Cell Activation Antibody-dependent Cellular Cytotoxicity Negative Regulation Of Mesenchymal Cell Proliferation Pyruvate Decarboxylation To Acetyl-CoA Pyruvate Dehydrogenase Complex Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Protein Localization To Cell Periphery Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Ventricular Cardiac Muscle Cell Development	Regulation Of Defense Response Regulation Of Cell Activation Regulation Of Immune Response Immune Effector Process Regulation Of Immune System Process Regulation Of Innate Immune Response T Cell Costimulation Myeloid Leukocyte Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune System Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Leukocyte Activation Positive Regulation Of Immune System Process Cell Activation Positive Regulation Of Cell Activation Neutrophil Activation Immune Response-regulating Signaling Pathway Activation Of Immune Response Protein-containing Complex Positive Regulation Of Defense Response Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of T Cell Activation Regulation Of Cell-cell Adhesion Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Reactive Oxygen Species Metabolic Process Phosphotyrosine Residue Binding Regulation Of Cell Adhesion Mediated By Integrin B Cell Receptor Signaling Pathway Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Fc Receptor Signaling Pathway Neutrophil Activation Involved In Immune Response Immune Response-activating Signaling Pathway Response To Stress Regulation Of Transport Regulation Of MAPK Cascade Positive Regulation Of Immune Response Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Regulation Of Inflammatory Response Activation Of Innate Immune Response Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein Localization Protein Kinase Binding Positive Regulation Of Superoxide Anion Generation Regulation Of Cell Adhesion Regulation Of Superoxide Anion Generation Positive Regulation Of Transport Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Response To External Biotic Stimulus
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