FCER1A and ITIH2

Number of citations of the paper that reports this interaction (PMID 10917520)
36

Data Source:
HPRD (in vitro)

		FCER1A	ITIH2
Gene Name		Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide	inter-alpha-trypsin inhibitor heavy chain 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface	Extracellular Region Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	IgE Receptor Activity IgE Binding	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity
	Biological Process	Positive Regulation Of Type I Hypersensitivity Serotonin Secretion Activation Of JUN Kinase Activity Leukotriene Biosynthetic Process Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Mast Cell Degranulation Innate Immune Response Positive Regulation Of Interleukin-3 Biosynthetic Process Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Calcium-mediated Signaling	Negative Regulation Of Endopeptidase Activity Hyaluronan Metabolic Process
Pathways		FCERI mediated NF-kB activation Fc epsilon receptor (FCERI) signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization Role of LAT2/NTAL/LAB on calcium mobilization Innate Immune System
Drugs		Omalizumab Benzylpenicilloyl Polylysine Alpha-D-Mannose
Diseases
GWAS		C-reactive protein ( 22939635) IgE levels ( 18846228 22075330) Obesity-related traits ( 23251661) Select biomarker traits ( 17903293)	Ovarian reserve ( 22116950)
Protein-Protein Interactions		4 interactors: FCER1G ITIH2 MS4A2 PDHB	3 interactors: ATP5C1 FCER1A SPINT2
Entrez ID		2205	3698
HPRD ID		00917	00890
Ensembl ID		ENSG00000179639	ENSG00000151655
Uniprot IDs		P12319	P19823
PDB IDs		1ALS 1ALT 1F2Q 1F6A 1J86 1J87 1J88 1J89 1RPQ 2Y7Q
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Mast Cell Degranulation Positive Regulation Of Mast Cell Activation Positive Regulation Of Regulated Secretory Pathway Regulation Of Mast Cell Degranulation Regulation Of Mast Cell Activation Regulation Of Regulated Secretory Pathway Positive Regulation Of Exocytosis Positive Regulation Of Type III Hypersensitivity Regulation Of Exocytosis Acetyl-CoA Biosynthetic Process From Pyruvate Positive Regulation Of Mast Cell Cytokine Production Positive Regulation Of Type I Hypersensitivity Serotonin Secretion By Platelet Positive Regulation Of Type IIa Hypersensitivity Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Intracellular Transport Fc Receptor Signaling Pathway Serotonin Secretion Acetyl-CoA Biosynthetic Process Positive Regulation Of Cell Activation Negative Regulation Of Mast Cell Apoptotic Process Positive Regulation Of Secretion Regulation Of Mast Cell Apoptotic Process Serotonin Transport Positive Regulation Of Hypersensitivity Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Vesicle-mediated Transport Neutrophil Activation Involved In Immune Response Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Inflammatory Response Regulation Of Intracellular Transport Positive Regulation Of Inflammatory Response To Antigenic Stimulus Phagocytosis, Engulfment Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Secretion By Cell Regulation Of Acyl-CoA Biosynthetic Process Membrane Invagination Negative Regulation Of Myeloid Cell Apoptotic Process Acetyl-CoA Metabolic Process Neutrophil Activation Secretion Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Positive Regulation Of Immune Response Regulation Of Secretion Monoamine Transport Positive Regulation Of Acute Inflammatory Response Production Of Molecular Mediator Involved In Inflammatory Response Positive Regulation Of Interleukin-10 Production	Positive Regulation Of Interleukin-3 Biosynthetic Process Positive Regulation Of Type I Hypersensitivity Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Serotonin Secretion Serotonin Transport Positive Regulation Of Hypersensitivity Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Positive Regulation Of Mast Cell Degranulation Positive Regulation Of Inflammatory Response To Antigenic Stimulus Positive Regulation Of Mast Cell Activation Mitochondrial ATP Synthesis Coupled Proton Transport Monovalent Inorganic Cation Transport Positive Regulation Of Regulated Secretory Pathway Leukotriene Biosynthetic Process Monoamine Transport Regulation Of Mast Cell Degranulation Positive Regulation Of Acute Inflammatory Response Positive Regulation Of Calcium-mediated Signaling ATP Synthesis Coupled Proton Transport Leukotriene Metabolic Process Positive Regulation Of Immunoglobulin Mediated Immune Response Regulation Of Mast Cell Activation Activation Of JUN Kinase Activity Regulation Of Regulated Secretory Pathway ATP Biosynthetic Process Regulation Of Calcium-mediated Signaling Icosanoid Biosynthetic Process Unsaturated Fatty Acid Biosynthetic Process Cation Transport Positive Regulation Of Exocytosis Positive Regulation Of Cytokine Biosynthetic Process Ammonium Transport Positive Regulation Of JUN Kinase Activity Oxidative Phosphorylation Regulation Of Acute Inflammatory Response Purine Ribonucleoside Monophosphate Biosynthetic Process Regulation Of JUN Kinase Activity Nucleoside Triphosphate Biosynthetic Process JNK Cascade Ribonucleoside Monophosphate Biosynthetic Process Positive Regulation Of Inflammatory Response Icosanoid Metabolic Process
Tagcloud ?		adam33 allergen allergens allergic black boston cnot6 cockroach dataset dust genotypic haplotype haplotypes house il5ra jak3 maml1 marginally mite nod1 rs11739089 rs12136904t rs6665683 rs6665683t rs7851969 sensitization sensitizations snps strongest	5mg breakdown bred conceptus corn cypionate ecm endometrial endometrium expresses gestation gilts glycocalyx hyaluronic il6 le linker lumenal microvilli pge pig snap surgically tnfaip6 trt trypsin uterine uterus
Tagcloud (Difference) ?		adam33 allergen allergens allergic black boston cnot6 cockroach dataset dust genotypic haplotype haplotypes house il5ra jak3 maml1 marginally mite nod1 rs11739089 rs12136904t rs6665683 rs6665683t rs7851969 sensitization sensitizations snps strongest	5mg breakdown bred conceptus corn cypionate ecm endometrial endometrium expresses gestation gilts glycocalyx hyaluronic il6 le linker lumenal microvilli pge pig snap surgically tnfaip6 trt trypsin uterine uterus
Tagcloud (Intersection) ?