FCER1A and ITIH2

Number of citations of the paper that reports this interaction (PubMedID 10917520)
0

Data Source:
HPRD (in vitro)

		FCER1A	ITIH2
Description		Fc epsilon receptor Ia	inter-alpha-trypsin inhibitor heavy chain 2
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane	Extracellular Region Endoplasmic Reticulum Lumen Extracellular Matrix Extracellular Exosome Blood Microparticle
	Molecular Function	Protein Binding High-affinity IgE Receptor Activity IgE Binding	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Hyaluronic Acid Binding Peptidase Inhibitor Activity
	Biological Process	Cell Surface Receptor Signaling Pathway Immunoglobulin Mediated Immune Response Type I Hypersensitivity Fc-epsilon Receptor Signaling Pathway Type 2 Immune Response Mast Cell Degranulation Eosinophil Degranulation	Hyaluronan Metabolic Process
Pathways		Fc epsilon receptor (FCERI) signaling Fc epsilon receptor (FCERI) signaling Role of LAT2/NTAL/LAB on calcium mobilization Role of LAT2/NTAL/LAB on calcium mobilization FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization FCERI mediated NF-kB activation	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs		Omalizumab Benzylpenicilloyl polylysine TNX-901	Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		C-reactive protein ( 22939635) IgE levels ( 18846228 22075330) Obesity-related traits ( 23251661) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912) Select biomarker traits ( 17903293) White blood cell count ( 27863252)	Ovarian reserve ( 22116950)
Interacting Genes		6 interacting genes: FCER1G ITIH2 LMNA MESD MS4A2 PDHB	3 interacting genes: ATP5F1C FCER1A SPINT2
Entrez ID		2205	3698
HPRD ID		00917	00890
Ensembl ID		ENSG00000179639	ENSG00000151655
Uniprot IDs		E9PRN1 P12319	P19823
PDB IDs		1F2Q 1F6A 1J86 1J87 1J88 1J89 1RPQ 2Y7Q 7SHT 8C1B 8C1C 8K7R 8YVU 8YWA 8Z0T 9EQ3 9EQ4
Enriched GO Terms of Interacting Partners?		Fc-epsilon Receptor I Complex IgE Binding IgG Binding Fc-gamma Receptor Signaling Pathway Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Fc Receptor Signaling Pathway External Side Of Plasma Membrane Positive Regulation Of Phagocytosis IgE Receptor Activity Positive Regulation Of Type I Hypersensitivity Negative Regulation Of Mast Cell Apoptotic Process Regulation Of Phagocytosis Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Tumor Necrosis Factor Production Localization Within Membrane Serotonin Secretion By Platelet Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Lymphocyte Mediated Immunity Fc-gamma Receptor III Complex Positive Regulation Of Type III Hypersensitivity DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina Pyruvate Dehydrogenase (acetyl-transferring) Activity Mast Cell Apoptotic Process Serotonin Secretion Positive Regulation Of Type IIa Hypersensitivity Leukocyte Mediated Immunity Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Positive Regulation Of Endocytosis Positive Regulation Of Mast Cell Cytokine Production Regulation Of Mast Cell Apoptotic Process Lamin Filament Nuclear Pore Localization Regulation Of Tumor Necrosis Factor Production Protein Localization To Plasma Membrane IgG Receptor Activity Positive Regulation Of Hypersensitivity Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Interleukin-3-mediated Signaling Pathway Mast Cell Activation Antibody-dependent Cellular Cytotoxicity Negative Regulation Of Mesenchymal Cell Proliferation Pyruvate Decarboxylation To Acetyl-CoA Pyruvate Dehydrogenase Complex Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Protein Localization To Cell Periphery Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Ventricular Cardiac Muscle Cell Development	High-affinity IgE Receptor Activity Type I Hypersensitivity Epithelial Cell Morphogenesis Involved In Placental Branching Eosinophil Degranulation IgE Binding Type 2 Immune Response Hypersensitivity
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